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Gene · 6646

SOAT1: sterol O-acyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SOAT1: sterol O-acyltransferase 1. Genes, record 6646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6646

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Gene

Symbol
SOAT1
HGNC
Name
sterol O-acyltransferase 1
HGNC
NCBI Gene ID
6646
NCBI Gene
HGNC ID
HGNC:11177
HGNC
Ensembl
ENSG00000057252
NCBI Gene
Aliases
ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35610Sterol O-acyltransferase 15505Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465612P35610Espacenet
EP 4650780 A22025-11-198266P35610Espacenet
JP 2025529142 A2025-09-044394P35610Espacenet
US 12371689 B22025-07-294394P35610Espacenet
JP 2025517970 A2025-06-128266P35610Espacenet
JP 2025032204 A2025-03-1136218P35610Espacenet
EP 4461818 A22024-11-1336218P35610Espacenet
US 11884978 B22024-01-30743P35610Espacenet
JP 2023058610 A2023-04-2536218P35610Espacenet
US 11446398 B22022-09-2084460P35610Espacenet

1 to 10 of 24

See all 24 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BENFLUOREXCHEMBL400599Acyl coenzyme A:cholesterol acyltransferase 1 inhibitorINHIBITORChEMBL
NEVANIMIBECHEMBL46423Acyl coenzyme A:cholesterol acyltransferase 1 inhibitorINHIBITORChEMBL
PACTIMIBECHEMBL478858Acyl coenzyme A:cholesterol acyltransferase 1 inhibitorINHIBITORChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02804178NEVANIMIBEPHASE22021-02-17ClinicalTrials.gov
NCT01898715NEVANIMIBEPHASE1ClinicalTrials.gov
NCT00544518BENFLUOREXPHASE2ClinicalTrials.gov
NCT00185146PACTIMIBEPHASE2ClinicalTrials.gov
NCT00185042PACTIMIBEPHASE2ClinicalTrials.gov

NIH grants847

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSOAT1 papersNewest fiscal year
P30DK017047Diabetes Research Center52025
P20GM113132The Institute for Biomolecular Targeting42025
R01DK104753Crosstalk Between Lipid Droplets and Other Organelles in Podocytes42025
R01EY027349Meibogenesis in Health, Disease, and Aging42025
P30CA008748Cancer Center Support Grant32025
P30CA023108Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R01NS104332Determining the role of lipid droplets and their therapeutic potential in glioblastoma32025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
P20GM103424Louisiana Biomedical Research Network22025

1 to 10 of 847Source NIH's project files

See all 847 nih grants

Papers1,513

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics integration reveals tissue-specific biosynthesis of sesquiterpenoids in the medicinal plant Eupatorium lindleyanum.PLoS One202642821537PubTator, text miningPubMed
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis.
Virus Genes202642801443PubTator, text miningPubMed
Automated clinical production, dosimetry estimates and preclinical safety considerations for clinical translation of a SOAT1-targeted PET imaging agent.Nucl Med Biol202642790341PubTator, text miningPubMed
Lipid metabolic reprogramming in clear cell renal cell carcinoma: focus on high-density lipoprotein-related pathways.Oncol Rev202642745992PubTator, text miningPubMed
Cholesterol Metabolism Regulation by Native and Oxidized Low-Density Lipoprotein in a Liver Cell Line.J Atheroscler Thromb202642716800PubTator, text miningPubMed
TRIM21 suppresses uterine corpus endometrial carcinoma progression by promoting K48 -linked ubiquitination and degradation of SOAT1.Front Immunol202642676445PubTator, text miningPubMed
Adaptation of Soil Viruses to Salinity Stress: Insights Into Genome Size Expansion and Functional Diversification.Environ Microbiol202642609044PubTator, text miningPubMed
Nilotinib inhibition of clear cell renal cell carcinoma proliferation and synergistic enhancement of sunitinib efficacy.Cell Signal202642586285PubTator, text miningPubMed
Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis.Front Immunol202642488674PubTator, text miningPubMed
Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.Stem Cell Res Ther202642436522PubTator, text miningPubMed

1 to 10 of 1,513

See all 1,513 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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