Gene · 6646
SOAT1: sterol O-acyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SOAT1: sterol O-acyltransferase 1. Genes, record 6646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6646
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35610 | Sterol O-acyltransferase 1 | 550 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65612 | P35610 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8266 | P35610 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4394 | P35610 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4394 | P35610 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8266 | P35610 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36218 | P35610 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36218 | P35610 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 743 | P35610 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 36218 | P35610 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 84460 | P35610 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BENFLUOREX | CHEMBL400599 | Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor | INHIBITOR | ChEMBL |
| NEVANIMIBE | CHEMBL46423 | Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor | INHIBITOR | ChEMBL |
| PACTIMIBE | CHEMBL478858 | Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor | INHIBITOR | ChEMBL |
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02804178 | NEVANIMIBE | PHASE2 | 2021-02-17 | ClinicalTrials.gov |
| NCT01898715 | NEVANIMIBE | PHASE1 | ClinicalTrials.gov | |
| NCT00544518 | BENFLUOREX | PHASE2 | ClinicalTrials.gov | |
| NCT00185146 | PACTIMIBE | PHASE2 | ClinicalTrials.gov | |
| NCT00185042 | PACTIMIBE | PHASE2 | ClinicalTrials.gov |
NIH grants847
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SOAT1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK017047 | Diabetes Research Center | 5 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 4 | 2025 |
| R01DK104753 | Crosstalk Between Lipid Droplets and Other Organelles in Podocytes | 4 | 2025 |
| R01EY027349 | Meibogenesis in Health, Disease, and Aging | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| R01NS104332 | Determining the role of lipid droplets and their therapeutic potential in glioblastoma | 3 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 3 | 2025 |
| P20GM103424 | Louisiana Biomedical Research Network | 2 | 2025 |
1 to 10 of 847Source NIH's project files
See all 847 nih grantsPapers1,513
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multi-omics integration reveals tissue-specific biosynthesis of sesquiterpenoids in the medicinal plant Eupatorium lindleyanum. | PLoS One | 2026 | 42821537 | PubTator, text mining | PubMed |
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis. | Virus Genes | 2026 | 42801443 | PubTator, text mining | PubMed |
| Automated clinical production, dosimetry estimates and preclinical safety considerations for clinical translation of a SOAT1-targeted PET imaging agent. | Nucl Med Biol | 2026 | 42790341 | PubTator, text mining | PubMed |
| Lipid metabolic reprogramming in clear cell renal cell carcinoma: focus on high-density lipoprotein-related pathways. | Oncol Rev | 2026 | 42745992 | PubTator, text mining | PubMed |
| Cholesterol Metabolism Regulation by Native and Oxidized Low-Density Lipoprotein in a Liver Cell Line. | J Atheroscler Thromb | 2026 | 42716800 | PubTator, text mining | PubMed |
| TRIM21 suppresses uterine corpus endometrial carcinoma progression by promoting K48 -linked ubiquitination and degradation of SOAT1. | Front Immunol | 2026 | 42676445 | PubTator, text mining | PubMed |
| Adaptation of Soil Viruses to Salinity Stress: Insights Into Genome Size Expansion and Functional Diversification. | Environ Microbiol | 2026 | 42609044 | PubTator, text mining | PubMed |
| Nilotinib inhibition of clear cell renal cell carcinoma proliferation and synergistic enhancement of sunitinib efficacy. | Cell Signal | 2026 | 42586285 | PubTator, text mining | PubMed |
| Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis. | Front Immunol | 2026 | 42488674 | PubTator, text mining | PubMed |
| Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor. | Stem Cell Res Ther | 2026 | 42436522 | PubTator, text mining | PubMed |
1 to 10 of 1,513
See all 1,513 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6646
GET https://conductscience.org/api/genes/v1/6646/patents?page=2