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SOD1: superoxide dismutase 1

1 protein, 212 patents, 1 drug, 6 trials, 12,896 NIH grants and 64,392 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSOD1HGNC
Namesuperoxide dismutase 1HGNC
NCBI Gene ID6647NCBI Gene
HGNC IDHGNC:11179HGNC
EnsemblENSG00000142168NCBI Gene
AliasesALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimerNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00441Superoxide dismutase [Cu-Zn]154156Ensembl, GeneID, HGNCUniProt

Patents 212

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026121201 A2026-06-116P00441Espacenet
EP 4724816 A22026-04-152P00441Espacenet
EP 4719461 A12026-04-08644P00441Espacenet
EP 4716540 A12026-04-0118P00441Espacenet
EP 4716542 A12026-04-0119P00441Espacenet
JP 2026004568 A2026-01-1465822P00441Espacenet
US 12497604 B22025-12-1632P00441Espacenet
WO 2025245381 A12025-11-27118P00441Espacenet
EP 4650780 A22025-11-192729P00441Espacenet
JP 2025169472 A2025-11-1317P00441Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TOFERSENCHEMBL3833346SOD1 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07294144TOFERSENPHASE2ClinicalTrials.gov
NCT07259980TOFERSENClinicalTrials.gov
NCT07223723TOFERSENPHASE4ClinicalTrials.gov
NCT04972487TOFERSENClinicalTrials.gov
NCT03070119TOFERSENPHASE32025-08-29ClinicalTrials.gov
NCT02623699TOFERSENPHASE32023-07-28ClinicalTrials.gov

NIH grants 12896

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA086862Cancer Center Support Grant632,025NIH's project files
R01NS027036Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias512,025NIH's project files
P30ES005605Environmental Health Sciences Research Center432,025NIH's project files
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis432,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)392,025NIH's project files
P30CA008748Cancer Center Support Grant292,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity262,025NIH's project files
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation252,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
R01ES004738Activated Macrophages and Ozone Toxicity212,025NIH's project files

Papers 64392

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827322PubTator, text miningPubMed
42824679PubTator, text miningPubMed
42822436PubTator, text miningPubMed
42821141PubTator, text miningPubMed
42817633PubTator, text miningPubMed
42816765PubTator, text miningPubMed
42815689PubTator, text miningPubMed
42814303PubTator, text miningPubMed
42814102PubTator, text miningPubMed
42812390PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license