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Gene · 6653

SORL1: sortilin related receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SORL1: sortilin related receptor 1. Genes, record 6653. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6653

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Gene

Symbol
SORL1
HGNC
Name
sortilin related receptor 1
HGNC
NCBI Gene ID
6653
NCBI Gene
HGNC ID
HGNC:11185
HGNC
Ensembl
ENSG00000137642
NCBI Gene
Aliases
C11orf32, LR11, LRP9, SORLA, SorLA, SorLA-1, gp250
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92673Sortilin-related receptor2,2147Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464947Q92673Espacenet
EP 4650780 A22025-11-191786Q92673Espacenet
EP 4641201 A22025-10-291372Q92673Espacenet
EP 4641202 A22025-10-2985Q92673Espacenet
EP 4641203 A22025-10-2957Q92673Espacenet
JP 2025529142 A2025-09-044400Q92673Espacenet
US 12371689 B22025-07-294400Q92673Espacenet
JP 2025517967 A2025-06-1257Q92673Espacenet
JP 2025517969 A2025-06-121372Q92673Espacenet
JP 2025517970 A2025-06-121786Q92673Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,959

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSORL1 papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)832025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study242025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions212025
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)212025
P30AG066509University of Washington Alzheimer's Disease Research Center182025
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE172025
R01NS017950Precursors of Stroke Incidence and Prognosis162025
U54AG052427Genome Center for Alzheimer's Disease (GCAD)122025
P30AG066462Alzheimer's Disease Research Center112025
P30DK063491Diabetes Research Center (DRC)92025

1 to 10 of 1,959Source NIH's project files

See all 1,959 nih grants

Papers2,220

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function.Alzheimers Dement202642768912PubTator, text miningPubMed
Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.Cancer Sci202642698291PubTator, text miningPubMed
SORL1 variant links endosomal amyloid precursor protein mis-sorting to axonal transport defects and neuronal dysfunction.Alzheimers Dement202642630093PubTator, text miningPubMed
Unraveling the molecular Nexus of Alzheimer's Disease and HIV encephalitis: The role of cellular senescence and transcriptional regulation.PLoS One202642594145PubTator, text miningPubMed
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.Nat Genet202642581323PubTator, text miningPubMed
LR11/SorLA and its role in cardiovascular disease.Int J Cardiol Heart Vasc202642571433PubTator, text miningPubMed
Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer's disease.Acta Neuropathol202642525245PubTator, text miningPubMed
Genetic and structural characterisation of alzheimer's disease associated variants in an Eastern Indian cohort.Metab Brain Dis202642412289PubTator, text miningPubMed
Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.Nat Commun202642401587PubTator, text miningPubMed
Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.Brain202642186854PubTator, text miningPubMed

1 to 10 of 2,220

See all 2,220 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6653

GET https://conductscience.org/api/genes/v1/6653/patents?page=2