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SOS1: SOS Ras/Rac guanine nucleotide exchange factor 1

1 protein, 70 patents, 0 drugs, 0 trials, 2,615 NIH grants and 4,813 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSOS1HGNC
NameSOS Ras/Rac guanine nucleotide exchange factor 1HGNC
NCBI Gene ID6654NCBI Gene
HGNC IDHGNC:11187HGNC
EnsemblENSG00000115904NCBI Gene
AliasesGF1, GGF1, GINGF, HGF, NS4, SOS-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07889Son of sevenless homolog 11,33392Ensembl, GeneID, HGNCUniProt

Patents 70

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911840Q07889Espacenet
EP 4641201 A22025-10-2912620Q07889Espacenet
JP 2025517969 A2025-06-1212620Q07889Espacenet
JP 2025517970 A2025-06-1211840Q07889Espacenet
JP 2025515285 A2025-05-143Q07889Espacenet
WO 2025059046 A12025-03-202Q07889Espacenet
JP 2025032204 A2025-03-1136291Q07889Espacenet
JP 2025032204 A2025-03-1136294Q07889Espacenet
US 12195465 B22025-01-143Q07889Espacenet
EP 4461818 A22024-11-1336291Q07889Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2615

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant312,025NIH's project files
P30CA016672Cancer Center Support Grant212,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR132,025NIH's project files
P30DK054759Precision Medicine Center for Cystic Fibrosis92,025NIH's project files
ZIABC010304Biochemical Basis of T Cell Activation92,025NIH's project files
P30CA068485Cancer Center Support Grant82,025NIH's project files
R01CA255232Isoform-specific signaling as a determinant of RAS-driven oncogenesis82,025NIH's project files
ZIABC010440Protein Structure, Stability, and Amyloid Formation82,025NIH's project files
P30CA016086Cancer Center Support Grant72,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy72,025NIH's project files

Papers 4813

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42759542PubTator, text miningPubMed
42738861PubTator, text miningPubMed
42720810PubTator, text miningPubMed
42716727PubTator, text miningPubMed
42712097PubTator, text miningPubMed
42711118PubTator, text miningPubMed
42678463PubTator, text miningPubMed
42654849PubTator, text miningPubMed
42624826PubTator, text miningPubMed
42622884PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license