ConductScience.org, home

Gene · 6658

SOX3: SRY-box transcription factor 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SOX3: SRY-box transcription factor 3. Genes, record 6658. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6658

On this page

Gene

Symbol
SOX3
HGNC
Name
SRY-box transcription factor 3
HGNC
NCBI Gene ID
6658
NCBI Gene
HGNC ID
HGNC:11199
HGNC
Ensembl
ENSG00000134595
NCBI Gene
Aliases
GHDX, MRGH, PHP, PHPX, SOXB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41225Transcription factor SOX-34460Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4810513 A12026-09-233P41225Espacenet
JP 2026004568 A2026-01-1465427P41225Espacenet
EP 4641201 A22025-10-299003P41225Espacenet
JP 2025147176 A2025-10-0615661P41225Espacenet
JP 2025530805 A2025-09-176P41225Espacenet
JP 2025517969 A2025-06-129003P41225Espacenet
KR 1020250068664 A2025-05-166P41225Espacenet
EP 4553154 A12025-05-1416P41225Espacenet
JP 2025028160 A2025-02-2815661P41225Espacenet
KR 1020250010750 A2025-01-2115661P41225Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants814

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSOX3 papersNewest fiscal year
IK6BX004854BLRD Research Career Scientist Award Application22025
P30CA008748Cancer Center Support Grant22025
P30CA016086Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025
P30EY008098Core Grant for Vision Research22025
R01HD078641Genomics of spermatogenic impairment22025
R35GM122550Genomic and Physiological Impact of Transposable Elements.22025

1 to 10 of 814Source NIH's project files

See all 814 nih grants

Papers1,530

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Charcot-Marie-Tooth Neuropathy (CMTX3) Complex Structural Variation Causes Differential SOX3 Spatiotemporal Expression.Hum Mutat202642729676PubTator, text miningPubMed
Understanding septo-optic dysplasia: Endocrine implications and ophthalmic consequences.Best Pract Res Clin Endocrinol Metab202642697756PubTator, text miningPubMed
Position effect at the SOX3 locus by an interchromosomal insertion causes hereditary spastic paraplegia.Am J Hum Genet202642497869PubTator, text miningPubMed
Integrative Transcriptomic Analysis Identifies a Key Candidate Gene Bridging Inflammation and DNA Repair in Endometriosis.Stem Cells Int202642483306PubTator, text miningPubMed
Synthesis and Development of Novel Small-Molecule MEIS2 Inhibitors That Induce Cell Death in Breast Cancer Cells by Targeting the Homeobox Domain.Pharmaceuticals (Basel)202642356499PubTator, text miningPubMed
Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort.Horm Res Paediatr202642054264PubTator, text miningPubMed
Cytogenomic Investigation of Individuals with Ovotesticular Difference of Sex Development.Sex Dev202642048305PubTator, text miningPubMed
Diverse SOX3 genetic variants and their associated phenotypic spectrum in human disease.Endocr Rev202642029673PubTator, text miningPubMed
ncRNA-Mediated Upregulation of AURKA Promotes Hepatocellular Carcinoma Progression and Alters the Immune Microenvironment.Bioinform Biol Insights202641908244PubTator, text miningPubMed
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.Cell Death Dis202641888518PubTator, text miningPubMed

1 to 10 of 1,530

See all 1,530 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6658

GET https://conductscience.org/api/genes/v1/6658/patents?page=2