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Gene · 6660

SOX5: SRY-box transcription factor 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SOX5: SRY-box transcription factor 5. Genes, record 6660. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6660

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Gene

Symbol
SOX5
HGNC
Name
SRY-box transcription factor 5
HGNC
NCBI Gene ID
6660
NCBI Gene
HGNC ID
HGNC:11201
HGNC
Ensembl
ENSG00000134532
NCBI Gene
Aliases
L-SOX5, L-SOX5B, L-SOX5F, LAMSHF, MGC35153
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35711Transcription factor SOX-57630Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465432P35711Espacenet
EP 4641201 A22025-10-2914436P35711Espacenet
JP 2025147176 A2025-10-0615664P35711Espacenet
JP 2025517969 A2025-06-1214436P35711Espacenet
JP 2025506185 A2025-03-0751P35711Espacenet
JP 2025028160 A2025-02-2815664P35711Espacenet
KR 1020250010750 A2025-01-2115664P35711Espacenet
EP 4479067 A22024-12-2551P35711Espacenet
JP 2024109657 A2024-08-1415503P35711Espacenet
JP 2023544161 A2023-10-2064P35711Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,622

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSOX5 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)62025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL62025
P30CA072720Cancer Center Support Grant42025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
P30AR072572UW Core Center for Clinical Research of Musculoskeletal Conditions32025
P30CA015704Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
R01MH123489Prediction of suicide death using EHR and polygenic risk scores32025

1 to 10 of 1,622Source NIH's project files

See all 1,622 nih grants

Papers1,923

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Shared genetic architecture across social disconnection, social disadvantage, and psychiatric and neurodevelopmental traits.Eur Arch Psychiatry Clin Neurosci202642814113PubTator, text miningPubMed
Genotype-dependent miR-499/SOX5 axis regulation and its association with chronic low back pain risk and severity.J Orthop Surg Res202642750036PubTator, text miningPubMed
A cascade-release microsphere-engineered injectable hydrogel enables immune remodeling and sustained chondrogenesis for facial cartilage regeneration.J Mater Chem B202642727235PubTator, text miningPubMed
Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head.iScience202642668562PubTator, text miningPubMed
CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage.Stem Cell Reports202642660118PubTator, text miningPubMed
Effectiveness of cognitive training on Lamb-Shaffer syndrome: a case report.Dement Neuropsychol202642657202PubTator, text miningPubMed
Genetic Etiology and Neurodevelopmental Outcomes in Children With Craniosynostosis: A 15-Year Single-Center Retrospective Study.J Craniofac Surg202642607197PubTator, text miningPubMed
Retraction Notice to: Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells.Mol Ther Nucleic Acids202642542639PubTator, text miningPubMed
Dysregulation of lncRNA MEG3/miR-21-5p Axis Impairs SOX5 Expression in Osteoarthritis.Genes (Basel)202642510788PubTator, text miningPubMed
Retraction notice to "Circ_0084653 promotes the tumor progression and immune escape in triple-negative breast cancer via the deubiquitination of MYC and upregulation of SOX5" [International Journal of Biological Macromolecules 280 (2024) 135655].
Int J Biol Macromol202642481325PubTator, text miningPubMed

1 to 10 of 1,923

See all 1,923 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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