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Gene · 6671

SP4: Sp4 transcription factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SP4: Sp4 transcription factor. Genes, record 6671. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6671

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Gene

Symbol
SP4
HGNC
Name
Sp4 transcription factor
HGNC
NCBI Gene ID
6671
NCBI Gene
HGNC ID
HGNC:11209
HGNC
Ensembl
ENSG00000105866
NCBI Gene
Aliases
HF1B, MGC130008, MGC130009, SPR-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02446Transcription factor Sp47840Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465016Q02446Espacenet
JP 2025147176 A2025-10-0615677Q02446Espacenet
JP 2025028160 A2025-02-2815677Q02446Espacenet
KR 1020250010750 A2025-01-2115677Q02446Espacenet
JP 2024109657 A2024-08-1415516Q02446Espacenet
US 11446398 B22022-09-2082664Q02446Espacenet
US 11400116 B22022-08-022784Q02446Espacenet
JP 2022524081 A2022-04-27185635Q02446Espacenet
JP 2021536249 A2021-12-2715870Q02446Espacenet
KR 1020210128370 A2021-10-2639Q02446Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants988

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSP4 papersNewest fiscal year
P30ES029067Texas A&M Center for Environmental Health Research (TiCER)92025
P30CA016672Cancer Center Support Grant82025
T32EY014537Research Training Program in Vision Science62025
T32ES026568Regulatory Science in Environmental Health and Toxicology52025
P30DK063491Diabetes Research Center (DRC)42025
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity42025
P30AR070254Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
UL1TR001881UCLA Clinical and Translational Science Institute32025
ZIAAR041203Muscle Disease Unit32025

1 to 10 of 988Source NIH's project files

See all 988 nih grants

Papers1,508

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia.bioRxiv202642818077PubTator, text miningPubMed
Clinical sub-phenotypes of co-occurring metabolic syndrome and pre-frailty and their associated factors in older adults: findings from Whitehall II study.Front Med (Lausanne)202642774087PubTator, text miningPubMed
IL-17 and IL-6 Trans-Signaling Coordinate Mesothelial Vascular Endothelial Growth Factor Production and Angiogenesis in the Peritoneum.Am J Pathol202642762971PubTator, text miningPubMed
Molecular and microstructural properties of functional behavior of particles from size-fractionated Durvillaea antarctica powders.Food Chem202642685424PubTator, text miningPubMed
MerTK Is Regulated by Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 in Colon Cancer Cells.Cancers (Basel)202642352525PubTator, text miningPubMed
The effect of sucrose palmitate characteristics as a surfactant on the physical stability of red palm oil submicroemulsions.J Adv Pharm Technol Res202642293263PubTator, text miningPubMed
The RBFOX1 regulatory gene network contributes to major depressive disorder, anxiety, irritability and neuroticism.Prog Neuropsychopharmacol Biol Psychiatry202642034278PubTator, text miningPubMed
The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets.Alzheimers Dement (N Y)202642004890PubTator, text miningPubMed
Cardiovascular and Autonomic Phenotypes Reveal Distinct Mechanisms of Sepsis Decompensation via Deep Learning.Res Sq202641928797PubTator, text miningPubMed
CancerHubs Data Explorer: a web application for investigating mutation-enriched protein interaction hubs in human cancers.BioData Min202641913220PubTator, text miningPubMed

1 to 10 of 1,508

See all 1,508 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6671

GET https://conductscience.org/api/genes/v1/6671/patents