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Gene · 668

FOXL2: forkhead box L2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FOXL2: forkhead box L2. Genes, record 668. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/668

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Gene

Symbol
FOXL2
HGNC
Name
forkhead box L2
HGNC
NCBI Gene ID
668
NCBI Gene
HGNC ID
HGNC:1092
HGNC
Ensembl
ENSG00000183770
NCBI Gene
Aliases
BPES, BPES1, PFRK, PINTO, POF3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P58012Forkhead box protein L23762Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446549P58012Espacenet
JP 2025147176 A2025-10-0615004P58012Espacenet
JP 2025028160 A2025-02-2815004P58012Espacenet
KR 1020250010750 A2025-01-2115004P58012Espacenet
JP 2024109657 A2024-08-1414843P58012Espacenet
US 11918604 B22024-03-0539P58012Espacenet
US 11918605 B12024-03-0539P58012Espacenet
US 11517589 B22022-12-0639P58012Espacenet
US 11446398 B22022-09-2032573P58012Espacenet
JP 2022524081 A2022-04-27135544P58012Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants785

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFOXL2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30CA016672Cancer Center Support Grant112025
P01AG029531The Aging Pituitary/Gonadal Axis52025
T32CA101642Training of Academic Gynecologic Oncologists52025
K12HD000849Reproductive Scientist Development Program42025
R01HD039963Opposing Pathways in Mammalian Sex Determination42025
ZIAES102965Impacts of Genetic and Environmental Factors on Reproductive Organ Development42025
P30DK063491Diabetes Research Center (DRC)32025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)32025
ZIAAG000646Placenta specific and ribosomal RNA genes: structure and function32025

1 to 10 of 785Source NIH's project files

See all 785 nih grants

Papers2,198

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Rare Case of a Sertoli Cell Tumor of the Adrenal Gland in a Man With Pathological Dexamethasone Suppression Test: A Case Report.Cureus202642801029PubTator, text miningPubMed
Integrative WGBS and ATAC-seq profiling reveals epigenetic and chromatin accessibility signatures associated with clutch length in goose ovaries.Poult Sci202642727346PubTator, text miningPubMed
[Clinicopathological analysis of 18 cases of ovarian juvenile granulosa cell tumor].Zhonghua Fu Chan Ke Za Zhi202642706059PubTator, text miningPubMed
STK11 adnexal tumor mimicking a female adnexal tumor of probable Wolffian origin (FATWO) associated with Peutz-Jeghers syndrome: A brief review.Indian J Pathol Microbiol202642696614PubTator, text miningPubMed
Two Cases of Steroid Cell Tumour, Not Otherwise Specified, of the Ovary with Distinct Exon 3 CTNNB1 Hotspot Mutations (p.D32V and p.S45P): Further Evidence of Wnt/β-Catenin-Pathway Involvement.Diagnostics (Basel)202642587701PubTator, text miningPubMed
Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs.FASEB J202642541334PubTator, text miningPubMed
Human iPSC-derived fetal granulosa-like cells enhance oocyte maturation outcomes and enable multi-generational safety evaluation in a mouse IVM model.J Reprod Dev202642528196PubTator, text miningPubMed
Report of two patients with variants in FOXL2 and KASH5 and review of gestational trophoblastic neoplasia after recurrent moles.J Assist Reprod Genet202642503564PubTator, text miningPubMed
Response to: comment on "FOXL2 expression in dysgenetic gonads supports the diagnostic possibility of ovotesticular differences of sex development".Virchows Arch202642400608PubTator, text miningPubMed
Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring.Food Chem Toxicol202642379508PubTator, text miningPubMed

1 to 10 of 2,198

See all 2,198 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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