Gene · 668
FOXL2: forkhead box L2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FOXL2: forkhead box L2. Genes, record 668. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/668
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P58012 | Forkhead box protein L2 | 376 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 46549 | P58012 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15004 | P58012 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15004 | P58012 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15004 | P58012 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 14843 | P58012 | Espacenet |
| US 11918604 B2 | 2024-03-05 | 39 | P58012 | Espacenet |
| US 11918605 B1 | 2024-03-05 | 39 | P58012 | Espacenet |
| US 11517589 B2 | 2022-12-06 | 39 | P58012 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 32573 | P58012 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 135544 | P58012 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants785
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FOXL2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P01AG029531 | The Aging Pituitary/Gonadal Axis | 5 | 2025 |
| T32CA101642 | Training of Academic Gynecologic Oncologists | 5 | 2025 |
| K12HD000849 | Reproductive Scientist Development Program | 4 | 2025 |
| R01HD039963 | Opposing Pathways in Mammalian Sex Determination | 4 | 2025 |
| ZIAES102965 | Impacts of Genetic and Environmental Factors on Reproductive Organ Development | 4 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 3 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 3 | 2025 |
| ZIAAG000646 | Placenta specific and ribosomal RNA genes: structure and function | 3 | 2025 |
1 to 10 of 785Source NIH's project files
See all 785 nih grantsPapers2,198
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Rare Case of a Sertoli Cell Tumor of the Adrenal Gland in a Man With Pathological Dexamethasone Suppression Test: A Case Report. | Cureus | 2026 | 42801029 | PubTator, text mining | PubMed |
| Integrative WGBS and ATAC-seq profiling reveals epigenetic and chromatin accessibility signatures associated with clutch length in goose ovaries. | Poult Sci | 2026 | 42727346 | PubTator, text mining | PubMed |
| [Clinicopathological analysis of 18 cases of ovarian juvenile granulosa cell tumor]. | Zhonghua Fu Chan Ke Za Zhi | 2026 | 42706059 | PubTator, text mining | PubMed |
| STK11 adnexal tumor mimicking a female adnexal tumor of probable Wolffian origin (FATWO) associated with Peutz-Jeghers syndrome: A brief review. | Indian J Pathol Microbiol | 2026 | 42696614 | PubTator, text mining | PubMed |
| Two Cases of Steroid Cell Tumour, Not Otherwise Specified, of the Ovary with Distinct Exon 3 CTNNB1 Hotspot Mutations (p.D32V and p.S45P): Further Evidence of Wnt/β-Catenin-Pathway Involvement. | Diagnostics (Basel) | 2026 | 42587701 | PubTator, text mining | PubMed |
| Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs. | FASEB J | 2026 | 42541334 | PubTator, text mining | PubMed |
| Human iPSC-derived fetal granulosa-like cells enhance oocyte maturation outcomes and enable multi-generational safety evaluation in a mouse IVM model. | J Reprod Dev | 2026 | 42528196 | PubTator, text mining | PubMed |
| Report of two patients with variants in FOXL2 and KASH5 and review of gestational trophoblastic neoplasia after recurrent moles. | J Assist Reprod Genet | 2026 | 42503564 | PubTator, text mining | PubMed |
| Response to: comment on "FOXL2 expression in dysgenetic gonads supports the diagnostic possibility of ovotesticular differences of sex development". | Virchows Arch | 2026 | 42400608 | PubTator, text mining | PubMed |
| Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring. | Food Chem Toxicol | 2026 | 42379508 | PubTator, text mining | PubMed |
1 to 10 of 2,198
See all 2,198 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/668
GET https://conductscience.org/api/genes/v1/668/patents?page=2