Gene · 6683
SPAST: spastin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPAST: spastin. Genes, record 6683. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6683
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UBP0 | Spastin | 616 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65072 | Q9UBP0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5340 | Q9UBP0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4407 | Q9UBP0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4407 | Q9UBP0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5340 | Q9UBP0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82806 | Q9UBP0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82808 | Q9UBP0 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4019 | Q9UBP0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 185777 | Q9UBP0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 185779 | Q9UBP0 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants861
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPAST papers | Newest fiscal year |
|---|---|---|---|
| R01NS072248 | Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome | 11 | 2025 |
| R35GM130234 | Chemical Biology of Cell Division | 8 | 2025 |
| R01GM112080 | ESCRT and MIT Complexes in Cytokinesis | 7 | 2025 |
| R01DK064380 | Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis | 6 | 2025 |
| ZIANS003165 | Mechanism of microtubule severing enzymes | 6 | 2025 |
| R01NS115977 | Elucidating the etiology of SPAST-based Hereditary Spastic Paraplegia | 5 | 2025 |
| K08NS123552 | Development of a Translational Research Platform to Understand and treat Defective Protein Trafficking in Childhood-Onset Hereditary Spastic Paraplegia | 4 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 4 | 2025 |
| P40OD018537 | Bloomington Drosophila Stock Center at Indiana University | 4 | 2025 |
| R35NS105078 | STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE | 4 | 2025 |
1 to 10 of 861Source NIH's project files
See all 861 nih grantsPapers1,637
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Phenotypic Spectrum and Clinical Approach to Early-Onset Hereditary Spastic Paraplegia. | Mov Disord Clin Pract | 2026 | 42764666 | PubTator, text mining | PubMed |
| Validation of a Cellular Imaging-Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia. | Ann Clin Transl Neurol | 2026 | 42687129 | PubTator, text mining | PubMed |
| Significant differences in phenotype and age of onset in an SPG4 family caused by whole SPAST deletion combined with a hemizygous S44L modifier. | Neurogenetics | 2026 | 42658319 | PubTator, text mining | PubMed |
| Late-Onset Hereditary Spastic Paraplegia with a Novel SPAST Intronic Variant. | Ann Lab Med | 2026 | 42613945 | PubTator, text mining | PubMed |
| SPG4-Associated Hereditary Spastic Paraplegia and Dilated Cardiomyopathy: Coincidence or Clue? | JACC Case Rep | 2026 | 42593014 | PubTator, text mining | PubMed |
| Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration. | J Neurochem | 2026 | 42563243 | PubTator, text mining | PubMed |
| SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy. | Mov Disord | 2026 | 42538614 | PubTator, text mining | PubMed |
| Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability. | Signal Transduct Target Ther | 2026 | 42521669 | PubTator, text mining | PubMed |
| Genotypic and Phenotypic Profile of Hereditary Spastic Paraplegia in Children: A Single-Centre Study from Northern India. | Indian Pediatr | 2026 | 42490029 | PubTator, text mining | PubMed |
| PTEN Negatively Regulates Spastin Ser210 Phosphorylation To Modulate GluA1 Surface Trafficking and Excitatory Synaptic Transmission. | ACS Chem Neurosci | 2026 | 42464651 | PubTator, text mining | PubMed |
1 to 10 of 1,637
See all 1,637 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6683
GET https://conductscience.org/api/genes/v1/6683/patents?page=2