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Gene · 6683

SPAST: spastin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPAST: spastin. Genes, record 6683. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6683

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Gene

Symbol
SPAST
HGNC
Name
spastin
HGNC
NCBI Gene ID
6683
NCBI Gene
HGNC ID
HGNC:11233
HGNC
Ensembl
ENSG00000021574
NCBI Gene
Aliases
ADPSP, FSP2, KIAA1083, SPG4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBP0Spastin6167Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465072Q9UBP0Espacenet
EP 4650780 A22025-11-195340Q9UBP0Espacenet
JP 2025529142 A2025-09-044407Q9UBP0Espacenet
US 12371689 B22025-07-294407Q9UBP0Espacenet
JP 2025517970 A2025-06-125340Q9UBP0Espacenet
US 11446398 B22022-09-2082806Q9UBP0Espacenet
US 11446398 B22022-09-2082808Q9UBP0Espacenet
US 11400116 B22022-08-024019Q9UBP0Espacenet
JP 2022524081 A2022-04-27185777Q9UBP0Espacenet
JP 2022524081 A2022-04-27185779Q9UBP0Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants861

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPAST papersNewest fiscal year
R01NS072248Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome112025
R35GM130234Chemical Biology of Cell Division82025
R01GM112080ESCRT and MIT Complexes in Cytokinesis72025
R01DK064380Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis62025
ZIANS003165Mechanism of microtubule severing enzymes62025
R01NS115977Elucidating the etiology of SPAST-based Hereditary Spastic Paraplegia52025
K08NS123552Development of a Translational Research Platform to Understand and treat Defective Protein Trafficking in Childhood-Onset Hereditary Spastic Paraplegia42025
P30CA042014Cancer Center Support Grant42025
P40OD018537Bloomington Drosophila Stock Center at Indiana University42025
R35NS105078STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE42025

1 to 10 of 861Source NIH's project files

See all 861 nih grants

Papers1,637

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phenotypic Spectrum and Clinical Approach to Early-Onset Hereditary Spastic Paraplegia.Mov Disord Clin Pract202642764666PubTator, text miningPubMed
Validation of a Cellular Imaging-Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia.Ann Clin Transl Neurol202642687129PubTator, text miningPubMed
Significant differences in phenotype and age of onset in an SPG4 family caused by whole SPAST deletion combined with a hemizygous S44L modifier.Neurogenetics202642658319PubTator, text miningPubMed
Late-Onset Hereditary Spastic Paraplegia with a Novel SPAST Intronic Variant.Ann Lab Med202642613945PubTator, text miningPubMed
SPG4-Associated Hereditary Spastic Paraplegia and Dilated Cardiomyopathy: Coincidence or Clue?JACC Case Rep202642593014PubTator, text miningPubMed
Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration.J Neurochem202642563243PubTator, text miningPubMed
SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy.Mov Disord202642538614PubTator, text miningPubMed
Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability.Signal Transduct Target Ther202642521669PubTator, text miningPubMed
Genotypic and Phenotypic Profile of Hereditary Spastic Paraplegia in Children: A Single-Centre Study from Northern India.Indian Pediatr202642490029PubTator, text miningPubMed
PTEN Negatively Regulates Spastin Ser210 Phosphorylation To Modulate GluA1 Surface Trafficking and Excitatory Synaptic Transmission.ACS Chem Neurosci202642464651PubTator, text miningPubMed

1 to 10 of 1,637

See all 1,637 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6683

GET https://conductscience.org/api/genes/v1/6683/patents?page=2