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SPINK1: serine peptidase inhibitor Kazal type 1

1 protein, 46 patents, 0 drugs, 0 trials, 2,375 NIH grants and 5,044 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSPINK1HGNC
Nameserine peptidase inhibitor Kazal type 1HGNC
NCBI Gene ID6690NCBI Gene
HGNC IDHGNC:11244HGNC
EnsemblENSG00000164266NCBI Gene
AliasesPCTT, PSTI, Spink3, TATI, TCPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00995Serine protease inhibitor Kazal-type 1795Ensembl, GeneID, HGNCUniProt

Patents 46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026012693 A2026-01-272P00995Espacenet
JP 2026012693 A2026-01-2786P00995Espacenet
JP 2026004568 A2026-01-1463047P00995Espacenet
EP 4650780 A22025-11-193758P00995Espacenet
JP 2025147176 A2025-10-0612703P00995Espacenet
JP 2025529142 A2025-09-047781P00995Espacenet
JP 2025111457 A2025-07-3082P00995Espacenet
US 12371689 B22025-07-297781P00995Espacenet
JP 2025517970 A2025-06-123758P00995Espacenet
JP 2025028160 A2025-02-2812703P00995Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2375

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U01DK108334INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies322,025NIH's project files
P30DK054759Precision Medicine Center for Cystic Fibrosis222,025NIH's project files
P30CA008748Cancer Center Support Grant202,025NIH's project files
U01DK108306UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes202,025NIH's project files
P30CA006973Regional Oncology Research Center162,025NIH's project files
P30CA016672Cancer Center Support Grant122,025NIH's project files
P50CA186786Michigan Prostate SPORE 2025-2030122,025NIH's project files
U01CA113913Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern112,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102,025NIH's project files
P50CA092629SPORE in Prostate Cancer82,025NIH's project files

Papers 5044

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807309PubTator, text miningPubMed
42757853PubTator, text miningPubMed
42757647PubTator, text miningPubMed
42745203PubTator, text miningPubMed
42687711PubTator, text miningPubMed
42653318PubTator, text miningPubMed
42652251PubTator, text miningPubMed
42651737PubTator, text miningPubMed
42641761PubTator, text miningPubMed
42611708PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license