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SPP1: secreted phosphoprotein 1

1 protein, 239 patents, 1 drug, 1 trial, 10,352 NIH grants and 29,848 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSPP1HGNC
Namesecreted phosphoprotein 1HGNC
NCBI Gene ID6696NCBI Gene
HGNC IDHGNC:11255HGNC
EnsemblENSG00000118785NCBI Gene
AliasesBNSP, BSPI, ETA-1, OPN, lnc-PKD2-2-3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10451Osteopontin3143Ensembl, GeneID, HGNCUniProt

Patents 239

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183143 A12026-09-031P10451Espacenet
WO 2026183147 A12026-09-031P10451Espacenet
EP 4777129 A12026-07-2277P10451Espacenet
JP 2026517854 A2026-06-028P10451Espacenet
EP 4719078 A22026-04-081P10451Espacenet
JP 2026501609 A2026-01-16421P10451Espacenet
EP 4650780 A22025-11-1911226P10451Espacenet
JP 2025147176 A2025-10-0612794P10451Espacenet
JP 2025529142 A2025-09-047800P10451Espacenet
US 12371689 B22025-07-297800P10451Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASK-8007CHEMBL2109530Osteopontin inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00411424ASK-8007PHASE1/PHASE2ClinicalTrials.gov

NIH grants 10352

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant682,025NIH's project files
P30CA008748Cancer Center Support Grant482,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
R01HL076246Chemokines in healing myocardial infarction182,025NIH's project files
R01HL085440Resolution of inflammation in healing myocardial infarcts182,025NIH's project files
P30CA016087Cancer Center Support Grant152,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program142,025NIH's project files
T32DE007057Tissue Engineering and Regeneration142,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support132,025NIH's project files
P30CA015704Cancer Center Support Grant132,025NIH's project files

Papers 29848

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826604PubTator, text miningPubMed
42825366PubTator, text miningPubMed
42824315PubTator, text miningPubMed
42822817PubTator, text miningPubMed
42821566PubTator, text miningPubMed
42821371PubTator, text miningPubMed
42821166PubTator, text miningPubMed
42820258PubTator, text miningPubMed
42819941PubTator, text miningPubMed
42819295PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license