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Gene · 6700

SPRR2A: small proline rich protein 2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPRR2A: small proline rich protein 2A. Genes, record 6700. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6700

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Gene

Symbol
SPRR2A
HGNC
Name
small proline rich protein 2A
HGNC
NCBI Gene ID
6700
NCBI Gene
HGNC ID
HGNC:11261
HGNC
Ensembl
ENSG00000241794
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35326Small proline-rich protein 2A720Ensembl, GeneID, HGNC

Source UniProt

Patents10

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463816P35326Espacenet
US 11446398 B22022-09-2080000P35326Espacenet
JP 2022524081 A2022-04-27182971P35326Espacenet
US 11078247 B22021-08-0310925P35326Espacenet
JP 2019054813 A2019-04-11244251P35326Espacenet
JP 2017121241 A2017-07-13244251P35326Espacenet
JP 2015516143 A2015-06-08244251P35326Espacenet
WO 2012081007 A22012-06-2132P35326Espacenet
EP 2052088 A22009-04-29336P35326Espacenet
EP 2052088 A22009-04-296704P35326Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants992

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPRR2A papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant32025
P20GM103442ND INBRE Health & the Environment22025
P30AI094189The Johns Hopkins Center for AIDS Research (JHU CFAR)22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
P30CA015704Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA016086Cancer Center Support Grant22025
P30CA056036Translational Research in Cancer22025
P30CA068485Cancer Center Support Grant22025

1 to 10 of 992Source NIH's project files

See all 992 nih grants

Papers1,491

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The effect of toll like receptors in prognosis in patients undergoing radical cystectomy for bladder cancer.Mol Biol Rep202642667340PubTator, text miningPubMed
Integrated Metabolomic and Transcriptomic Profiling Reveals a Distinct Pathological Aging State in Diminished Ovarian Reserve of Advanced Reproductive-Age Women.Reprod Sci202642426427PubTator, text miningPubMed
The SPRR2A-CSTA axis drives IL-17A-induced squamous metaplasia and steroid resistance in allergic rhinitis.J Allergy Clin Immunol202642269941PubTator, text miningPubMed
Single-cell and spatial transcriptomics reveal SPRR2A+ epithelial-MMP1+ fibroblast interactions as key drivers of Esophageal Squamous Cell Carcinoma progression.Int J Biol Macromol202642173220PubTator, text miningPubMed
Multi-omics analysis identified SPRR2D as a potential biomarker for tumor prognosis and immune microenvironment infiltration: a pan-cancer perspective.Future Sci OA202641933926PubTator, text miningPubMed
The Role of B Cells in Tumorigenesis and Immunotherapy.Immune Netw202641800023PubTator, text miningPubMed
Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells.Front Immunol202641798951PubTator, text miningPubMed
Dermal Fibroblasts, Not Keratinocytes, Dominate IL-17A/TNF-Driven Inflammation.Exp Dermatol202641755670PubTator, text miningPubMed
Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation.Eur J Immunol202641742604PubTator, text miningPubMed
Embolization of a profunda femoris artery injury following battlefield tourniquet application: A case report.Trauma Case Rep202641717329PubTator, text miningPubMed

1 to 10 of 1,491

See all 1,491 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6700

GET https://conductscience.org/api/genes/v1/6700/grants?page=2