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Gene · 671

BPI: bactericidal permeability increasing protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BPI: bactericidal permeability increasing protein. Genes, record 671. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/671

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Gene

Symbol
BPI
HGNC
Name
bactericidal permeability increasing protein
HGNC
NCBI Gene ID
671
NCBI Gene
HGNC ID
HGNC:1095
HGNC
Ensembl
ENSG00000101425
NCBI Gene
Aliases
BPIFD1, rBPI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17213Bactericidal permeability-increasing protein4872Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12509511 B22025-12-308P17213Espacenet
JP 2025169942 A2025-11-14872P17213Espacenet
JP 2025147176 A2025-10-061536P17213Espacenet
JP 2025529142 A2025-09-04596P17213Espacenet
JP 2025529142 A2025-09-045602P17213Espacenet
US 12371689 B22025-07-295602P17213Espacenet
US 12371689 B22025-07-29596P17213Espacenet
JP 2025062604 A2025-04-148164P17213Espacenet
JP 2025028160 A2025-02-281536P17213Espacenet
KR 1020250010750 A2025-01-211536P17213Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants767

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBPI papersNewest fiscal year
P30ES005605Environmental Health Sciences Research Center92025
T32AI007046Infectious Diseases Training Program62025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition42025
P30CA023108Cancer Center Support Grant32025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro32025
K12HD047349Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)22025
P30CA016672Cancer Center Support Grant22025
P30DA018343Yale/NIDA Neuroproteomics Center22025
P30DK017047Diabetes Research Center22025
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center22025

1 to 10 of 767Source NIH's project files

See all 767 nih grants

Papers1,446

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Augmented Anti-Bactericidal Permeability-Increasing Protein Antibody Levels in Rheumatoid Arthritis Patients Complicated by Usual Interstitial Pneumonia.J Clin Med202642513347PubTator, text miningPubMed
Therapeutic Efficacy of Sivelestat Sodium in ARDS Following Aortic Dissection: A Pilot Physiological Trial with Exploratory Transcriptomic Analysis.J Inflamm Res202642502580PubTator, text miningPubMed
Lipopolysaccharide-binding protein as a biomarker in the diagnosis of necrotizing enterocolitis.J Pediatr Surg202642203141PubTator, text miningPubMed
Pediatric ANCA-Associated Vasculitis: Variable Clinical Course in a Case Series of Three Patients and Literature Review.Children (Basel)202642194238PubTator, text miningPubMed
Characterization of Mucosal BPI fold-containing family A member 1-High-Expressing Neutrophils and their Immune Defense roles in Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection via single-cell RNA sequencing.
J Infect Dis202642139518PubTator, text miningPubMed
Identification of neutrophil-related genes associated with the severity of RSV infection.Microbiol Spectr202641995316PubTator, text miningPubMed
From Gut to Systemic Circulation: Molecular Strategies of Botulinum Neurotoxin Complexes.Toxins (Basel)202641893539PubTator, text miningPubMed
GRN and KLRB1 define a shared peripheral-blood transcriptomic signature linking SLE and IPF.J Transl Autoimmun202641782635PubTator, text miningPubMed
Ontogenesis of coelomocyte subsets and immune-related genes during Eisenia andrei embryogenesis.Dev Comp Immunol202641763506PubTator, text miningPubMed
Dynamic Covalent Platform for Chiroptically Tunable Figure-Eight Macrocycles from Preorganized Alkaloidal Scaffolds.JACS Au202641755847PubTator, text miningPubMed

1 to 10 of 1,446

See all 1,446 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/671

GET https://conductscience.org/api/genes/v1/671/patents?page=2