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SRC: SRC proto-oncogene, non-receptor tyrosine kinase

1 protein, 154 patents, 14 drugs, 408 trials, 18,829 NIH grants and 46,563 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSRCHGNC
NameSRC proto-oncogene, non-receptor tyrosine kinaseHGNC
NCBI Gene ID6714NCBI Gene
HGNC IDHGNC:11283HGNC
EnsemblENSG00000197122NCBI Gene
AliasesASV, SRC1, THC6, c-SRC, c-src, p60-SrcNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P12931Proto-oncogene tyrosine-protein kinase Src53679Ensembl, GeneID, HGNCUniProt

Patents 154

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197520P12931Espacenet
WO 2025219709 A12025-10-231P12931Espacenet
WO 2025219721 A22025-10-231P12931Espacenet
WO 2025184170 A12025-09-0428P12931Espacenet
EP 4577200 A22025-07-025P12931Espacenet
JP 2025517970 A2025-06-127520P12931Espacenet
JP 2025032204 A2025-03-1136472P12931Espacenet
JP 2025032204 A2025-03-1136473P12931Espacenet
JP 2025032204 A2025-03-1136475P12931Espacenet
EP 4484957 A12025-01-0130P12931Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-0424CHEMBL5314408Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
AZM-475271CHEMBL426161Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
BOSUTINIBCHEMBL288441Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
JNJ-26483327CHEMBL3109738Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
PD-0166285CHEMBL49120Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
PD-0166285 HYDROCHLORIDECHEMBL3545196Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL
SARACATINIBCHEMBL217092Tyrosine-protein kinase SRC inhibitorINHIBITORChEMBL

Trials 408

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07273656TIRBANIBULINPHASE3ClinicalTrials.gov
NCT07010692TIRBANIBULINPHASE1/PHASE2ClinicalTrials.gov
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT06423911BOSUTINIBPHASE3ClinicalTrials.gov
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06297161BOSUTINIBClinicalTrials.gov
NCT06135415TIRBANIBULINPHASE3ClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov

NIH grants 18829

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant5142,025NIH's project files
P30CA008748Cancer Center Support Grant1862,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase762,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant742,025NIH's project files
P30CA068485Cancer Center Support Grant732,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant642,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant642,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant562,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)552,025NIH's project files
P30CA016058Cancer Center Support Grant532,025NIH's project files

Papers 46563

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822966PubTator, text miningPubMed
42822143PubTator, text miningPubMed
42821487PubTator, text miningPubMed
42819776PubTator, text miningPubMed
42816892PubTator, text miningPubMed
42816015PubTator, text miningPubMed
42815640PubTator, text miningPubMed
42814539PubTator, text miningPubMed
42813677PubTator, text miningPubMed
42812828PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license