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SRD5A1: steroid 5 alpha-reductase 1
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Gene · 6715

Papers879

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 879

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TitleJournalYearPMIDFound bySource
Inherited Predisposition in Steroidogenic Pathways and Risk of Transition to Incurable Prostate Cancer in Men With Localized Disease.J Urol202642821636PubTator, text miningPubMed
Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia.Int J Mol Sci202642737762PubTator, text miningPubMed
Neurotoxicological concerns: Azole fungicides as mixed/noncompetitive inhibitors of human and rat 5α-reductase 1.J Hazard Mater202642721833PubTator, text miningPubMed
Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights.Comput Biol Chem202642585776PubTator, text miningPubMed
Chain-length-selective inhibition of human and rat steroid 5α-reductase type 1 by alkyltrimethylammonium chloride disinfectants: kinetic, surface plasmon resonance, computational, and network toxicology analyses with implications for neurosteroidogenesis.
Chem Biol Interact202642580472PubTator, text miningPubMed
Integrated network toxicology and bioinformatics approaches explore potential mechanisms linking organophosphate flame retardant exposure to rheumatoid arthritis.Mol Divers202642530799PubTator, text miningPubMed
Differences between human and rat 5α-Reductase 1 inhibition by phenolic disinfectants: Comparative kinetics and binding modes for neurosteroid synthesis.Chem Biol Interact202642235909PubTator, text miningPubMed
Association of Oral Contraceptives with Adverse Pregnancy Outcomes: A Mendelian Randomization and Colocalization Study.Curr Med Chem202642227521PubTator, text miningPubMed
Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region.Genome Biol202642151982PubTator, text miningPubMed
Multiple targets and pathways non-monotonically regulate lung squamous cell carcinoma migration in response to phthalates.Food Chem Toxicol202642106106PubTator, text miningPubMed
Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition.J Neuroendocrinol202641877439PubTator, text miningPubMed
Bridging the Gap: How environmental exposures compromise male fertility and clinical Outlook.Curr Res Toxicol202641809136PubTator, text miningPubMed
Protocol for single-cell optimization objective and trade-off inference.STAR Protoc202641790544PubTator, text miningPubMed
Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies.Front Pharmacol202641769701PubTator, text miningPubMed
Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer.Research (Wash D C)202641743623PubTator, text miningPubMed
Emerging therapies to overcome antiandrogen resistance and beyond in lethal prostate cancer.J Natl Cancer Cent202641738039PubTator, text miningPubMed
Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity.Toxicol Lett202641722875PubTator, text miningPubMed
5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes.NeuroSci202641718149PubTator, text miningPubMed
Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Front Endocrinol (Lausanne)202641710411PubTator, text miningPubMed
SRD5A2 and emerging therapies in androgen-driven disorders.Nat Rev Urol202641501168PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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