Gene · 6715
SRD5A1: steroid 5 alpha-reductase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SRD5A1: steroid 5 alpha-reductase 1. Genes, record 6715. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6715
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 259 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65598 | P18405 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4443 | P18405 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4443 | P18405 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 84439 | P18405 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 926 | P18405 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 187410 | P18405 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 246033 | P18405 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 246033 | P18405 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 246033 | P18405 | Espacenet |
| JP 2010162017 A | 2010-07-29 | 1743 | P18405 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials154
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07570979 | ABIRATERONE | PHASE1 | ClinicalTrials.gov | |
| NCT07553988 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07421804 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07417449 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07299292 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07237269 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07226986 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07190300 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07154914 | ABIRATERONE | ClinicalTrials.gov | ||
| NCT07140900 | ABIRATERONE | PHASE1 | ClinicalTrials.gov |
1 to 10 of 154
See all 154 trialsNIH grants622
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SRD5A1 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 13 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 12 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 9 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 9 | 2025 |
| R01CA172382 | Elucidating a novel molecular biomarker for castration-resistant prostate cancer | 8 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| ZIABC010453 | Genetics and Molecular Mechanisms of Prostate Cancer | 5 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 4 | 2025 |
1 to 10 of 622Source NIH's project files
See all 622 nih grantsPapers879
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Inherited Predisposition in Steroidogenic Pathways and Risk of Transition to Incurable Prostate Cancer in Men With Localized Disease. | J Urol | 2026 | 42821636 | PubTator, text mining | PubMed |
| Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia. | Int J Mol Sci | 2026 | 42737762 | PubTator, text mining | PubMed |
| Neurotoxicological concerns: Azole fungicides as mixed/noncompetitive inhibitors of human and rat 5α-reductase 1. | J Hazard Mater | 2026 | 42721833 | PubTator, text mining | PubMed |
| Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights. | Comput Biol Chem | 2026 | 42585776 | PubTator, text mining | PubMed |
Chain-length-selective inhibition of human and rat steroid 5α-reductase type 1 by alkyltrimethylammonium chloride disinfectants: kinetic, surface plasmon resonance, computational, and network toxicology analyses with implications for neurosteroidogenesis. | Chem Biol Interact | 2026 | 42580472 | PubTator, text mining | PubMed |
| Integrated network toxicology and bioinformatics approaches explore potential mechanisms linking organophosphate flame retardant exposure to rheumatoid arthritis. | Mol Divers | 2026 | 42530799 | PubTator, text mining | PubMed |
| Differences between human and rat 5α-Reductase 1 inhibition by phenolic disinfectants: Comparative kinetics and binding modes for neurosteroid synthesis. | Chem Biol Interact | 2026 | 42235909 | PubTator, text mining | PubMed |
| Association of Oral Contraceptives with Adverse Pregnancy Outcomes: A Mendelian Randomization and Colocalization Study. | Curr Med Chem | 2026 | 42227521 | PubTator, text mining | PubMed |
| Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region. | Genome Biol | 2026 | 42151982 | PubTator, text mining | PubMed |
| Multiple targets and pathways non-monotonically regulate lung squamous cell carcinoma migration in response to phthalates. | Food Chem Toxicol | 2026 | 42106106 | PubTator, text mining | PubMed |
1 to 10 of 879
See all 879 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6715
GET https://conductscience.org/api/genes/v1/6715/patents