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Gene · 6715

SRD5A1: steroid 5 alpha-reductase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SRD5A1: steroid 5 alpha-reductase 1. Genes, record 6715. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6715

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Gene

Symbol
SRD5A1
HGNC
Name
steroid 5 alpha-reductase 1
HGNC
NCBI Gene ID
6715
NCBI Gene
HGNC ID
HGNC:11284
HGNC
Ensembl
ENSG00000145545
NCBI Gene
Aliases
S5AR 1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P184053-oxo-5-alpha-steroid 4-dehydrogenase 12590Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465598P18405Espacenet
JP 2025529142 A2025-09-044443P18405Espacenet
US 12371689 B22025-07-294443P18405Espacenet
US 11446398 B22022-09-2084439P18405Espacenet
US 11400116 B22022-08-02926P18405Espacenet
JP 2022524081 A2022-04-27187410P18405Espacenet
JP 2019054813 A2019-04-11246033P18405Espacenet
JP 2017121241 A2017-07-13246033P18405Espacenet
JP 2015516143 A2015-06-08246033P18405Espacenet
JP 2010162017 A2010-07-291743P18405Espacenet

1 to 10 of 15

See all 15 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABIRATERONECHEMBL254328Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL
DUTASTERIDECHEMBL1200969Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL

Trials154

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07570979ABIRATERONEPHASE1ClinicalTrials.gov
NCT07553988ABIRATERONEPHASE2ClinicalTrials.gov
NCT07421804DUTASTERIDEClinicalTrials.gov
NCT07417449DUTASTERIDEClinicalTrials.gov
NCT07299292ABIRATERONEPHASE2ClinicalTrials.gov
NCT07237269ABIRATERONEPHASE2ClinicalTrials.gov
NCT07226986ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07190300ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07154914ABIRATERONEClinicalTrials.gov
NCT07140900ABIRATERONEPHASE1ClinicalTrials.gov

1 to 10 of 154

See all 154 trials

NIH grants622

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSRD5A1 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology132025
P50CA097186The Pacific Northwest Prostate Cancer SPORE122025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer92025
P30CA016056Roswell Park Cancer Center Support Grant92025
R01CA172382Elucidating a novel molecular biomarker for castration-resistant prostate cancer82025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b582025
P30CA016672Cancer Center Support Grant62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
ZIABC010453Genetics and Molecular Mechanisms of Prostate Cancer52025
P50CA092629SPORE in Prostate Cancer42025

1 to 10 of 622Source NIH's project files

See all 622 nih grants

Papers879

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inherited Predisposition in Steroidogenic Pathways and Risk of Transition to Incurable Prostate Cancer in Men With Localized Disease.J Urol202642821636PubTator, text miningPubMed
Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia.Int J Mol Sci202642737762PubTator, text miningPubMed
Neurotoxicological concerns: Azole fungicides as mixed/noncompetitive inhibitors of human and rat 5α-reductase 1.J Hazard Mater202642721833PubTator, text miningPubMed
Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights.Comput Biol Chem202642585776PubTator, text miningPubMed
Chain-length-selective inhibition of human and rat steroid 5α-reductase type 1 by alkyltrimethylammonium chloride disinfectants: kinetic, surface plasmon resonance, computational, and network toxicology analyses with implications for neurosteroidogenesis.
Chem Biol Interact202642580472PubTator, text miningPubMed
Integrated network toxicology and bioinformatics approaches explore potential mechanisms linking organophosphate flame retardant exposure to rheumatoid arthritis.Mol Divers202642530799PubTator, text miningPubMed
Differences between human and rat 5α-Reductase 1 inhibition by phenolic disinfectants: Comparative kinetics and binding modes for neurosteroid synthesis.Chem Biol Interact202642235909PubTator, text miningPubMed
Association of Oral Contraceptives with Adverse Pregnancy Outcomes: A Mendelian Randomization and Colocalization Study.Curr Med Chem202642227521PubTator, text miningPubMed
Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region.Genome Biol202642151982PubTator, text miningPubMed
Multiple targets and pathways non-monotonically regulate lung squamous cell carcinoma migration in response to phthalates.Food Chem Toxicol202642106106PubTator, text miningPubMed

1 to 10 of 879

See all 879 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6715

GET https://conductscience.org/api/genes/v1/6715/patents