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BRAF: B-Raf proto-oncogene, serine/threonine kinase

1 protein, 210 patents, 20 drugs, 1,261 trials, 13,360 NIH grants and 68,535 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBRAFHGNC
NameB-Raf proto-oncogene, serine/threonine kinaseHGNC
NCBI Gene ID673NCBI Gene
HGNC IDHGNC:1097HGNC
EnsemblENSG00000157764NCBI Gene
AliasesB-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P15056Serine/threonine-protein kinase B-raf766131Ensembl, GeneID, HGNCUniProt

Patents 210

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4796650 A22026-08-262P15056Espacenet
WO 2026121966 A22026-06-117P15056Espacenet
JP 2026511570 A2026-04-1436P15056Espacenet
EP 4720110 A12026-04-081P15056Espacenet
WO 2026071097 A2026-04-0215P15056Espacenet
EP 4670728 A12025-12-3136P15056Espacenet
KR 1020250166953 A2025-11-2836P15056Espacenet
WO 2025238172 A12025-11-202P15056Espacenet
JP 2025536257 A2025-11-051P15056Espacenet
WO 2025226822 A22025-10-301P15056Espacenet

Drugs 20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARQ-736CHEMBL5314407Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
ARQ-736 FREE ACIDCHEMBL5316167Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
BELVARAFENIBCHEMBL3977543RAF serine/threonine protein kinase inhibitorINHIBITORChEMBL
CEP-32496CHEMBL2029988Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
DABRAFENIBCHEMBL2028663Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
DABRAFENIB MESYLATECHEMBL2105729Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
ENCORAFENIBCHEMBL3301612Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
LGX-806CHEMBL3545263Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
LIFIRAFENIBCHEMBL4209157Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL
LY-3009120CHEMBL3577124Serine/threonine-protein kinase B-raf inhibitorINHIBITORChEMBL

Trials 1261

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695SORAFENIBClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07506109DABRAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463651SORAFENIBPHASE3ClinicalTrials.gov
NCT07463248SORAFENIBPHASE2ClinicalTrials.gov

NIH grants 13360

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1,2742,025NIH's project files
P30CA016672Cancer Center Support Grant9582,025NIH's project files
P30CA006973Regional Oncology Research Center1862,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program1572,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1552,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1482,025NIH's project files
P30CA016058Cancer Center Support Grant1472,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1452,025NIH's project files
P30CA068485Cancer Center Support Grant1002,025NIH's project files
P30CA047904Cancer Center Support Grant932,025NIH's project files

Papers 68535

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827401PubTator, text miningPubMed
42827277PubTator, text miningPubMed
42826365PubTator, text miningPubMed
42825158PubTator, text miningPubMed
42823659PubTator, text miningPubMed
42823486PubTator, text miningPubMed
42823149PubTator, text miningPubMed
42822592PubTator, text miningPubMed
42821536PubTator, text miningPubMed
42820284PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license