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TRIM21: tripartite motif containing 21

1 protein, 76 patents, 0 drugs, 0 trials, 3,380 NIH grants and 14,443 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTRIM21HGNC
Nametripartite motif containing 21HGNC
NCBI Gene ID6737NCBI Gene
HGNC IDHGNC:11312HGNC
EnsemblENSG00000132109NCBI Gene
AliasesRNF81, RO52, Ro/SSA, SSA, SSA1, TRIM21/Ro52NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P19474E3 ubiquitin-protein ligase TRIM2147520Ensembl, GeneID, HGNCUniProt

Patents 76

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026030445 A12026-02-0524P19474Espacenet
JP 2026004568 A2026-01-1467993P19474Espacenet
JP 2025541179 A2025-12-1836P19474Espacenet
EP 4650780 A22025-11-191494P19474Espacenet
EP 4630459 A12025-10-1536P19474Espacenet
JP 2025530217 A2025-09-11102P19474Espacenet
JP 2025523594 A2025-07-231P19474Espacenet
JP 2025517970 A2025-06-121494P19474Espacenet
WO 2025101862 A12025-05-1527P19474Espacenet
US 12285470 B22025-04-298P19474Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3380

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U54GM104938Oklahoma Shared Clinical and Translational Resources552,025NIH's project files
R01AI024717Genetic Linkage in Lupus352,025NIH's project files
ZIADE000704Clinical and Mechanistic Investigations of Salivary Gland Dysfunction332,025NIH's project files
P30AR073750Oklahoma Rheumatic Disease Research Cores Center232,025NIH's project files
ZIAAR041203Muscle Disease Unit202,025NIH's project files
P30AR070254Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)182,025NIH's project files
UM1AI144292Oklahoma ACE: Molecular Destruction of Autoimmune Disease to Aid Clinical Trail Success182,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
ZIADE000695Adeno-associated Virus Biology And Utilization For Gene Transfer132,025NIH's project files

Papers 14443

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826135PubTator, text miningPubMed
42824490PubTator, text miningPubMed
42816460PubTator, text miningPubMed
42815213PubTator, text miningPubMed
42810773PubTator, text miningPubMed
42810004PubTator, text miningPubMed
42806046PubTator, text miningPubMed
42802111PubTator, text miningPubMed
42801887PubTator, text miningPubMed
42798645PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license