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Gene · 6752

SSTR2: somatostatin receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SSTR2: somatostatin receptor 2. Genes, record 6752. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6752

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Gene

Symbol
SSTR2
HGNC
Name
somatostatin receptor 2
HGNC
NCBI Gene ID
6752
NCBI Gene
HGNC ID
HGNC:11331
HGNC
Ensembl
ENSG00000180616
NCBI Gene
Aliases
SST2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30874Somatostatin receptor type 236917Ensembl, GeneID, HGNC

Source UniProt

Patents96

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1052P30874Espacenet
JP 2025529142 A2025-09-044456P30874Espacenet
US 12371689 B22025-07-294456P30874Espacenet
JP 2025515134 A2025-05-1355P30874Espacenet
JP 2025515134 A2025-05-1370P30874Espacenet
EP 4519294 A12025-03-1255P30874Espacenet
EP 4519294 A12025-03-1270P30874Espacenet
JP 2025032204 A2025-03-1136507P30874Espacenet
EP 4461818 A22024-11-1336507P30874Espacenet
US 12121590 B22024-10-22121P30874Espacenet

1 to 10 of 96

See all 96 patents

Drugs14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LANREOTIDECHEMBL1201185Somatostatin receptor 2 agonistAGONISTChEMBL
LANREOTIDE ACETATECHEMBL1201184Somatostatin receptor 2 agonistAGONISTChEMBL
LUTETIUM OXODOTREOTIDECHEMBL4302409Somatostatin receptor binding agentBINDING AGENTChEMBL
LUTETIUM OXODOTREOTIDE LU-177CHEMBL4297545Somatostatin receptor binding agentBINDING AGENTChEMBL
OCTREOTIDECHEMBL1680Somatostatin receptor agonistAGONISTChEMBL
OCTREOTIDE ACETATECHEMBL1200480Somatostatin receptor agonistAGONISTChEMBL
ONZIGOLIDECHEMBL4650342Somatostatin receptor 2 agonistAGONISTChEMBL
PALTUSOTINECHEMBL5267842Somatostatin receptor 2 agonistAGONISTChEMBL
PASIREOTIDECHEMBL3349607Somatostatin receptor 2 agonistAGONISTChEMBL
PASIREOTIDE DIASPARTATECHEMBL5314380Somatostatin receptor 2 agonistAGONISTChEMBL

1 to 10 of 14

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Trials397

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07595237LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07583563OCTREOTIDEClinicalTrials.gov
NCT07537010LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07534371SOMATOSTATINClinicalTrials.gov
NCT07460908OCTREOTIDEClinicalTrials.gov
NCT07316686LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07304466SOMATOSTATINClinicalTrials.gov
NCT07252401SOMATOSTATINClinicalTrials.gov
NCT07229768LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07189871LUTETIUM OXODOTREOTIDE LU-177PHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 397

See all 397 trials

NIH grants1,123

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSSTR2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant332025
P30CA086862Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant162025
P30CA013148Comprehensive Cancer Center Support Grant82025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
K12CA184746MSK Paul Calabresi Career Development Award for Clinical Oncology42025
P01HL131478Stress-induced immune reprogramming in cardiovascular disease42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
UL1TR002384Clinical and Translational Science Center42025
ZIADK053200Diagnosis, Natural History, Management, tumor biology of Gastrinomas/PETs/Neuroendocrine tumors42025

1 to 10 of 1,123Source NIH's project files

See all 1,123 nih grants

Papers3,968

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SSTR2 receptor states and cellular metabolism modulate 177Lu-DOTATATE binding affinity.EANM Innov202642819901PubTator, text miningPubMed
Octreotide-Mediated Co-Solubilization of Paclitaxel and Docetaxel: A Novel Targeted Formulation for Synergistic Anticancer Chemotherapy.Pharmaceutics202642797334PubTator, text miningPubMed
Predictors of in vitro response to somatostatin and dopamine receptor-targeted treatments are lacking in clinically non-functioning pituitary tumors.J Neuroendocrinol202642785810PubTator, text miningPubMed
Revisiting Alzheimer's Disease Through the Somatostatin-Mitochondria Axis.Mol Neurobiol202642782557PubTator, text miningPubMed
Hepatocyte nuclear factor 4 alpha defines a distinct subtype of lung carcinoid with therapeutic potential targeting somatostatin receptor 2.Virchows Arch202642782345PubTator, text miningPubMed
Targeting overexpressed tumor cell receptors with radiolabeled molecules: Biological targets, clinical applications, and translational challenges.Bioorg Chem202642762619PubTator, text miningPubMed
Somatostatin and its type 2 receptor expression in the pregnant and laboring myometrium.Am J Physiol Cell Physiol202642747790PubTator, text miningPubMed
Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.Ann N Y Acad Sci202642734243PubTator, text miningPubMed
Patient-derived 3D organotypic co-cultures as a long-term ex vivo model for pleomorphic adenoma of the parotid gland.Sci Rep202642733102PubTator, text miningPubMed
Potential of sweetener substitutes to circumvent metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis risk: Integrating network toxicology and validation in vitro.Food Chem Toxicol202642732869PubTator, text miningPubMed

1 to 10 of 3,968

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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