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Gene · 6753

SSTR3: somatostatin receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SSTR3: somatostatin receptor 3. Genes, record 6753. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6753

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Gene

Symbol
SSTR3
HGNC
Name
somatostatin receptor 3
HGNC
NCBI Gene ID
6753
NCBI Gene
HGNC ID
HGNC:11332
HGNC
Ensembl
ENSG00000278195
NCBI Gene
Aliases
SS-3-R, SS3-R, SS3R, SSR-28, SST3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32745Somatostatin receptor type 34183Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464915P32745Espacenet
JP 2026004568 A2026-01-1464916P32745Espacenet
JP 2025172069 A2025-11-20660P32745Espacenet
JP 2025172069 A2025-11-20661P32745Espacenet
US 12247982 B22025-03-11660P32745Espacenet
US 12247982 B22025-03-11661P32745Espacenet
JP 2023113918 A2023-08-16660P32745Espacenet
JP 2023113918 A2023-08-16661P32745Espacenet
US 11541119 B22023-01-0312P32745Espacenet
US 11446398 B22022-09-2082334P32745Espacenet

1 to 10 of 50

See all 50 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LUTETIUM OXODOTREOTIDECHEMBL4302409Somatostatin receptor binding agentBINDING AGENTChEMBL
LUTETIUM OXODOTREOTIDE LU-177CHEMBL4297545Somatostatin receptor binding agentBINDING AGENTChEMBL
OCTREOTIDECHEMBL1680Somatostatin receptor agonistAGONISTChEMBL
OCTREOTIDE ACETATECHEMBL1200480Somatostatin receptor agonistAGONISTChEMBL
PASIREOTIDECHEMBL3349607Somatostatin receptor 3 agonistAGONISTChEMBL
PASIREOTIDE DIASPARTATECHEMBL5314380Somatostatin receptor 3 agonistAGONISTChEMBL
PASIREOTIDE PAMOATECHEMBL5314382Somatostatin receptor 3 agonistAGONISTChEMBL
SOMATOSTATINCHEMBL1823872Somatostatin receptor agonistAGONISTChEMBL
VAPREOTIDECHEMBL3349523Somatostatin receptor 3 agonistAGONISTChEMBL

Trials335

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07595237LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07583563OCTREOTIDEClinicalTrials.gov
NCT07537010LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07534371SOMATOSTATINClinicalTrials.gov
NCT07460908OCTREOTIDEClinicalTrials.gov
NCT07316686LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07304466SOMATOSTATINClinicalTrials.gov
NCT07252401SOMATOSTATINClinicalTrials.gov
NCT07229768LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07189871LUTETIUM OXODOTREOTIDE LU-177PHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 335

See all 335 trials

NIH grants509

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSSTR3 papersNewest fiscal year
R01GM089933Quality Control of the cilia proteome112025
P30CA016672Cancer Center Support Grant62025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology62025
R01GM060992Intraflagellar Transport Proteins in Mice62025
P30CA008748Cancer Center Support Grant52025
P30DK020579Diabetes Research Center42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA086862Cancer Center Support Grant32025
R35GM122552Super-resolution Microscopy Study of Molecular Transport Mechanisms32025
P30CA013148Comprehensive Cancer Center Support Grant22025

1 to 10 of 509Source NIH's project files

See all 509 nih grants

Papers1,165

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Predictors of in vitro response to somatostatin and dopamine receptor-targeted treatments are lacking in clinically non-functioning pituitary tumors.J Neuroendocrinol202642785810PubTator, text miningPubMed
Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.J Cell Physiol202642436646PubTator, text miningPubMed
Primary cilia and neural computation.J Biomed Sci202642231312PubTator, text miningPubMed
Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas.Mol Biomed202641928014PubTator, text miningPubMed
Targeted and Personalized Therapy for Difficult Benign Brain Tumors: A Review.J Pers Med202641893038PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed
Structural and dynamic insights into ligand recognition and activation of somatostatin receptor 3.Acta Pharmacol Sin202641673456PubTator, text miningPubMed
Distribution of Somatostatin and Its Receptors in the Intestinal Tract in Healthy Patients and Patients with Type 2 Diabetes.J Clin Endocrinol Metab202641379811PubTator, text miningPubMed
Altered somatostatin receptor 3 expression and functional dysregulation in tuberous sclerosis complex.Prog Neurobiol202641352576PubTator, text miningPubMed
Clinical and Pathological Spectrum of Acromegaly: Distinguishing GH PitNETs, Mammosomatotrophs, and Mixed Tumors.J Clin Endocrinol Metab202641296644PubTator, text miningPubMed

1 to 10 of 1,165

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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