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Gene · 6754

SSTR4: somatostatin receptor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SSTR4: somatostatin receptor 4. Genes, record 6754. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6754

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Gene

Symbol
SSTR4
HGNC
Name
somatostatin receptor 4
HGNC
NCBI Gene ID
6754
NCBI Gene
HGNC ID
HGNC:11333
HGNC
Ensembl
ENSG00000132671
NCBI Gene
Aliases
SS-4-R, SS4-R, SS4R, SST4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P31391Somatostatin receptor type 43882Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464917P31391Espacenet
JP 2026000906 A2026-01-06247P31391Espacenet
EP 4641201 A22025-10-291143P31391Espacenet
JP 2025529142 A2025-09-044457P31391Espacenet
US 12371689 B22025-07-294457P31391Espacenet
JP 2025517969 A2025-06-121143P31391Espacenet
US 11708610 B22023-07-25838P31391Espacenet
JP 2023521339 A2023-05-24247P31391Espacenet
US 11541119 B22023-01-0316P31391Espacenet
US 11446398 B22022-09-2082336P31391Espacenet

1 to 10 of 46

See all 46 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LUTETIUM OXODOTREOTIDECHEMBL4302409Somatostatin receptor binding agentBINDING AGENTChEMBL
LUTETIUM OXODOTREOTIDE LU-177CHEMBL4297545Somatostatin receptor binding agentBINDING AGENTChEMBL
OCTREOTIDECHEMBL1680Somatostatin receptor agonistAGONISTChEMBL
OCTREOTIDE ACETATECHEMBL1200480Somatostatin receptor agonistAGONISTChEMBL
SOMATOSTATINCHEMBL1823872Somatostatin receptor agonistAGONISTChEMBL
VELDOREOTIDECHEMBL3989911Somatostatin receptor 4 agonistAGONISTChEMBL

Trials286

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07595237LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07583563OCTREOTIDEClinicalTrials.gov
NCT07537010LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07534371SOMATOSTATINClinicalTrials.gov
NCT07460908OCTREOTIDEClinicalTrials.gov
NCT07316686LUTETIUM OXODOTREOTIDE LU-177PHASE1ClinicalTrials.gov
NCT07304466SOMATOSTATINClinicalTrials.gov
NCT07252401SOMATOSTATINClinicalTrials.gov
NCT07229768LUTETIUM OXODOTREOTIDE LU-177EARLY_PHASE1ClinicalTrials.gov
NCT07189871LUTETIUM OXODOTREOTIDE LU-177PHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 286

See all 286 trials

NIH grants410

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSSTR4 papersNewest fiscal year
P30CA086862Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant32025
P30DK020593Vanderbilt Diabetes Research Center32025
P20GM103440Nevada IDeA Networks of Biomedical Research Excellence (INBRE)22025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025
R01CA134675Enhanced imaging and treatment of aggressive subtypes of prostate cancer22025
R01GM089933Quality Control of the cilia proteome22025
F99NS141387The Role of Brain-Specific Angiogenesis Inhibitor 2 (BAI2) in Synaptic Structural Organization and Functional Dynamics12025
K12CA086913Paul Calabresi Award in Clinical Oncology Research12025
P20GM103446Delaware INBRE12025

1 to 10 of 410Source NIH's project files

See all 410 nih grants

Papers849

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Revisiting Alzheimer's Disease Through the Somatostatin-Mitochondria Axis.Mol Neurobiol202642782557PubTator, text miningPubMed
Novel Substituted Carboxamides as SSTR4 Agonists.ACS Med Chem Lett202642445033PubTator, text miningPubMed
Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.J Cell Physiol202642436646PubTator, text miningPubMed
Cross-Species Quantitative Benchmarking of SSTR2 Radioligands in Fresh-Frozen Brain Sections: An Adaptable Framework for Radiopharmaceutical Development.Mol Imaging Biol202642423881PubTator, text miningPubMed
Structural and Functional Basis of SSTR5 Homodimerization in Controlling Receptor Signaling and Pasireotide Response in Corticotroph Adenomas.FASEB J202642141916PubTator, text miningPubMed
Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas.Mol Biomed202641928014PubTator, text miningPubMed
To test or not to test: what we have learnt from 50 years of dynamic testing in acromegaly.Pituitary202641915107PubTator, text miningPubMed
Role of Growth Hormone (GH) and Other Somatotropic Axis Elements in Retinal Neuroprotection.Curr Issues Mol Biol202641899448PubTator, text miningPubMed
Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides.Org Lett202641729728PubTator, text miningPubMed
Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles.Drug Des Devel Ther202641710577PubTator, text miningPubMed

1 to 10 of 849

See all 849 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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