Gene · 6754
SSTR4: somatostatin receptor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SSTR4: somatostatin receptor 4. Genes, record 6754. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6754
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31391 | Somatostatin receptor type 4 | 388 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64917 | P31391 | Espacenet |
| JP 2026000906 A | 2026-01-06 | 247 | P31391 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1143 | P31391 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4457 | P31391 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4457 | P31391 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1143 | P31391 | Espacenet |
| US 11708610 B2 | 2023-07-25 | 838 | P31391 | Espacenet |
| JP 2023521339 A | 2023-05-24 | 247 | P31391 | Espacenet |
| US 11541119 B2 | 2023-01-03 | 16 | P31391 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82336 | P31391 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| LUTETIUM OXODOTREOTIDE | CHEMBL4302409 | Somatostatin receptor binding agent | BINDING AGENT | ChEMBL |
| LUTETIUM OXODOTREOTIDE LU-177 | CHEMBL4297545 | Somatostatin receptor binding agent | BINDING AGENT | ChEMBL |
| OCTREOTIDE | CHEMBL1680 | Somatostatin receptor agonist | AGONIST | ChEMBL |
| OCTREOTIDE ACETATE | CHEMBL1200480 | Somatostatin receptor agonist | AGONIST | ChEMBL |
| SOMATOSTATIN | CHEMBL1823872 | Somatostatin receptor agonist | AGONIST | ChEMBL |
| VELDOREOTIDE | CHEMBL3989911 | Somatostatin receptor 4 agonist | AGONIST | ChEMBL |
Trials286
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07595237 | LUTETIUM OXODOTREOTIDE LU-177 | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07583563 | OCTREOTIDE | ClinicalTrials.gov | ||
| NCT07537010 | LUTETIUM OXODOTREOTIDE LU-177 | PHASE1 | ClinicalTrials.gov | |
| NCT07534371 | SOMATOSTATIN | ClinicalTrials.gov | ||
| NCT07460908 | OCTREOTIDE | ClinicalTrials.gov | ||
| NCT07316686 | LUTETIUM OXODOTREOTIDE LU-177 | PHASE1 | ClinicalTrials.gov | |
| NCT07304466 | SOMATOSTATIN | ClinicalTrials.gov | ||
| NCT07252401 | SOMATOSTATIN | ClinicalTrials.gov | ||
| NCT07229768 | LUTETIUM OXODOTREOTIDE LU-177 | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07189871 | LUTETIUM OXODOTREOTIDE LU-177 | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 286
See all 286 trialsNIH grants410
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SSTR4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA086862 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 3 | 2025 |
| P20GM103440 | Nevada IDeA Networks of Biomedical Research Excellence (INBRE) | 2 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 2 | 2025 |
| R01CA134675 | Enhanced imaging and treatment of aggressive subtypes of prostate cancer | 2 | 2025 |
| R01GM089933 | Quality Control of the cilia proteome | 2 | 2025 |
| F99NS141387 | The Role of Brain-Specific Angiogenesis Inhibitor 2 (BAI2) in Synaptic Structural Organization and Functional Dynamics | 1 | 2025 |
| K12CA086913 | Paul Calabresi Award in Clinical Oncology Research | 1 | 2025 |
| P20GM103446 | Delaware INBRE | 1 | 2025 |
1 to 10 of 410Source NIH's project files
See all 410 nih grantsPapers849
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Revisiting Alzheimer's Disease Through the Somatostatin-Mitochondria Axis. | Mol Neurobiol | 2026 | 42782557 | PubTator, text mining | PubMed |
| Novel Substituted Carboxamides as SSTR4 Agonists. | ACS Med Chem Lett | 2026 | 42445033 | PubTator, text mining | PubMed |
| Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues. | J Cell Physiol | 2026 | 42436646 | PubTator, text mining | PubMed |
| Cross-Species Quantitative Benchmarking of SSTR2 Radioligands in Fresh-Frozen Brain Sections: An Adaptable Framework for Radiopharmaceutical Development. | Mol Imaging Biol | 2026 | 42423881 | PubTator, text mining | PubMed |
| Structural and Functional Basis of SSTR5 Homodimerization in Controlling Receptor Signaling and Pasireotide Response in Corticotroph Adenomas. | FASEB J | 2026 | 42141916 | PubTator, text mining | PubMed |
| Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas. | Mol Biomed | 2026 | 41928014 | PubTator, text mining | PubMed |
| To test or not to test: what we have learnt from 50 years of dynamic testing in acromegaly. | Pituitary | 2026 | 41915107 | PubTator, text mining | PubMed |
| Role of Growth Hormone (GH) and Other Somatotropic Axis Elements in Retinal Neuroprotection. | Curr Issues Mol Biol | 2026 | 41899448 | PubTator, text mining | PubMed |
| Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides. | Org Lett | 2026 | 41729728 | PubTator, text mining | PubMed |
| Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles. | Drug Des Devel Ther | 2026 | 41710577 | PubTator, text mining | PubMed |
1 to 10 of 849
See all 849 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6754
GET https://conductscience.org/api/genes/v1/6754/patents?page=2