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STAT3: signal transducer and activator of transcription 3

1 protein, 157 patents, 2 drugs, 14 trials, 25,033 NIH grants and 93,348 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSTAT3HGNC
Namesignal transducer and activator of transcription 3HGNC
NCBI Gene ID6774NCBI Gene
HGNC IDHGNC:11364HGNC
EnsemblENSG00000168610NCBI Gene
AliasesADMIO, ADMIO1, APRF, HIESNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40763Signal transducer and activator of transcription 37706Ensembl, GeneID, HGNCUniProt

Patents 157

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0372P40763Espacenet
WO 2025262045 A12025-12-265P40763Espacenet
EP 4661970 A12025-12-1762168P40763Espacenet
EP 4650780 A22025-11-192378P40763Espacenet
EP 4641201 A22025-10-291951P40763Espacenet
JP 2025147176 A2025-10-0615696P40763Espacenet
JP 2025532979 A2025-10-03176P40763Espacenet
EP 4618968 A12025-09-2446P40763Espacenet
WO 2025181335 A12025-09-045P40763Espacenet
EP 4593850 A22025-08-06176P40763Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANVATIRSENCHEMBL4297739STAT-3 mRNA 3'UTR antisense inhibitorANTISENSE INHIBITORChEMBL
DANVATIRSEN SODIUMCHEMBL4297244STAT-3 mRNA 3'UTR antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05986240DANVATIRSENPHASE1ClinicalTrials.gov
NCT05814666DANVATIRSENPHASE22026-01-30ClinicalTrials.gov
NCT03819465DANVATIRSENPHASE1ClinicalTrials.gov
NCT03794544DANVATIRSENPHASE22022-02-24ClinicalTrials.gov
NCT03527147DANVATIRSENPHASE1ClinicalTrials.gov
NCT03421353DANVATIRSENPHASE1ClinicalTrials.gov
NCT03334617DANVATIRSENPHASE22025-10-27ClinicalTrials.gov
NCT02983578DANVATIRSENPHASE2ClinicalTrials.gov
NCT02549651DANVATIRSENPHASE1ClinicalTrials.gov
NCT02546661DANVATIRSENPHASE1ClinicalTrials.gov

NIH grants 25033

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant6492,025NIH's project files
P30CA008748Cancer Center Support Grant2792,025NIH's project files
P30CA016058Cancer Center Support Grant1332,025NIH's project files
P30CA033572Cancer Center Support Grant1052,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1022,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award882,025NIH's project files
P30CA047904Cancer Center Support Grant862,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant842,025NIH's project files
P50CA097190Head and Neck Cancer SPORE792,025NIH's project files
P30CA006973Regional Oncology Research Center782,025NIH's project files

Papers 93348

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827143PubTator, text miningPubMed
42827142PubTator, text miningPubMed
42826468PubTator, text miningPubMed
42825898PubTator, text miningPubMed
42824327PubTator, text miningPubMed
42824075PubTator, text miningPubMed
42823155PubTator, text miningPubMed
42823085PubTator, text miningPubMed
42822277PubTator, text miningPubMed
42822143PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license