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AURKA: aurora kinase A

1 protein, 161 patents, 19 drugs, 94 trials, 4,905 NIH grants and 11,539 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAURKAHGNC
Nameaurora kinase AHGNC
NCBI Gene ID6790NCBI Gene
HGNC IDHGNC:11393HGNC
EnsemblENSG00000087586NCBI Gene
AliasesAIK, ARK1, AURA, AurA, BTAK, PPP1R47, STK15, STK6, STK7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14965Aurora kinase A403193Ensembl, GeneID, HGNCUniProt

Patents 161

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19374O14965Espacenet
EP 4641202 A22025-10-294324O14965Espacenet
JP 2025517970 A2025-06-12374O14965Espacenet
JP 2025062604 A2025-04-147893O14965Espacenet
JP 2025062604 A2025-04-147894O14965Espacenet
JP 2025062604 A2025-04-147895O14965Espacenet
JP 2025062604 A2025-04-147897O14965Espacenet
JP 2025062604 A2025-04-147898O14965Espacenet
JP 2025062604 A2025-04-147899O14965Espacenet
JP 2025062604 A2025-04-147900O14965Espacenet

Drugs 19

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALISERTIBCHEMBL483158Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORChEMBL
AMG-900CHEMBL2140408Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
AT-9283CHEMBL495727Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORChEMBL
CENISERTIBCHEMBL1967878Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
CYC-116CHEMBL482967Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
DANUSERTIBCHEMBL402548Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
ENMD-2076CHEMBL482968Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
KW-2449CHEMBL1908397Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORChEMBL

Trials 94

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07465757ALISERTIBPHASE2ClinicalTrials.gov
NCT06369285ALISERTIBPHASE2ClinicalTrials.gov
NCT06095505ALISERTIBPHASE2ClinicalTrials.gov
NCT04555837ALISERTIBPHASE1/PHASE22024-12-16ClinicalTrials.gov
NCT04479306ALISERTIBPHASE1ClinicalTrials.gov
NCT04085315ALISERTIBPHASE1ClinicalTrials.gov
NCT03005262ALISERTIBClinicalTrials.gov
NCT02860000ALISERTIBPHASE22024-10-18ClinicalTrials.gov
NCT02719691ALISERTIBPHASE12022-01-19ClinicalTrials.gov
NCT02700022ALISERTIBPHASE1ClinicalTrials.gov

NIH grants 4905

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1412,025NIH's project files
P30CA008748Cancer Center Support Grant772,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase532,025NIH's project files
P30CA016359Cancer Center Support Grant282,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant282,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant282,025NIH's project files
P30CA006973Regional Oncology Research Center262,025NIH's project files
P30CA068485Cancer Center Support Grant252,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE232,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant222,025NIH's project files

Papers 11539

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823848PubTator, text miningPubMed
42821234PubTator, text miningPubMed
42800385PubTator, text miningPubMed
42789740PubTator, text miningPubMed
42789387PubTator, text miningPubMed
42785447PubTator, text miningPubMed
42785137PubTator, text miningPubMed
42780611PubTator, text miningPubMed
42775268PubTator, text miningPubMed
42771089PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license