Gene · 6792
CDKL5: cyclin dependent kinase like 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDKL5: cyclin dependent kinase like 5. Genes, record 6792. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6792
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O76039 | Cyclin-dependent kinase-like 5 | 960 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12624353 B2 | 2026-05-12 | 3994 | O76039 | Espacenet |
| US 12624354 B2 | 2026-05-12 | 3994 | O76039 | Espacenet |
| US 12570972 B2 | 2026-03-10 | 3994 | O76039 | Espacenet |
| US 12509680 B2 | 2025-12-30 | 3994 | O76039 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23629 | O76039 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23629 | O76039 | Espacenet |
| WO 2025122548 A1 | 2025-06-12 | 6413 | O76039 | Espacenet |
| US 12281303 B2 | 2025-04-22 | 3994 | O76039 | Espacenet |
| WO 2025050032 A1 | 2025-03-06 | 1 | O76039 | Espacenet |
| WO 2025038796 A1 | 2025-02-20 | 6413 | O76039 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants741
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDKL5 papers | Newest fiscal year |
|---|---|---|---|
| U01NS114312 | Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder | 21 | 2025 |
| P50HD105351 | Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center | 13 | 2025 |
| P50HD103537 | Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt | 11 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 7 | 2025 |
| R01NS057819 | MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME | 3 | 2025 |
| R01NS058721 | ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders | 3 | 2025 |
| T32GM007748 | Training Grant in Genetics | 3 | 2025 |
| T32HG000035 | Interdisciplinary Training in Genome Sciences | 3 | 2025 |
| U54NS092090 | Developmental Synaptopathies Associated with TSC, PTEN, SHANK3 and SynGAP1 Pathogenic Variants | 3 | 2025 |
| DP5OD033357 | Long-read DNA and RNA sequencing to identify disease-causing genetic variation and streamline testing | 2 | 2025 |
1 to 10 of 741Source NIH's project files
See all 741 nih grantsPapers1,482
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Heterozygous Variant in the GABBR2 Gene in a Girl With Clinical Classic Rett Syndrome. | Mol Genet Genomic Med | 2026 | 42802491 | PubTator, text mining | PubMed |
| [Effectiveness and tolerability of ketogenic diet therapy in children with genetic developmental and epileptic encephalopathy onset within 2 years of age]. | Zhonghua Er Ke Za Zhi | 2026 | 42742013 | PubTator, text mining | PubMed |
| TRACE: A Framework for Integrating Transcript Relevance Into ACMG/AMP Variant Interpretation. | Hum Mutat | 2026 | 42707628 | PubTator, text mining | PubMed |
| Associations between EEG measures and clinical severity in CDKL5 deficiency disorder. | Clin Neurophysiol | 2026 | 42632229 | PubTator, text mining | PubMed |
| CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder. | Iran J Pharm Res | 2026 | 42488191 | PubTator, text mining | PubMed |
| Cyclin-dependent kinases as signaling integrators in cancer: Structural evolution, functional plasticity, and drug discovery. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42435947 | PubTator, text mining | PubMed |
| Clinical electrophysiological characteristics of cyclin-dependent kinase-like 5 gene induced developmental and epileptic encephalopathy (CDKL5-DEE). | Epileptic Disord | 2026 | 42412596 | PubTator, text mining | PubMed |
| Immune and clinicopathological features of molecularly defined prolactinoma subtypes. | J Neurosurg | 2026 | 42361377 | PubTator, text mining | PubMed |
| Comprehensive High-Depth Proteomic Analysis of Plasma Extracellular Vesicle-Containing Preparations in CDKL5 Deficiency Disorder. | Biomedicines | 2026 | 42193287 | PubTator, text mining | PubMed |
| From Sea to Therapy: Development and Analytical Control of Recombinant Human CDKL5 Production in the Marine Bacterium Pseudoalteromonas haloplanktis TAC125. | Mar Drugs | 2026 | 42188286 | PubTator, text mining | PubMed |
1 to 10 of 1,482
See all 1,482 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6792
GET https://conductscience.org/api/genes/v1/6792/patents?page=2