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Gene · 6792

CDKL5: cyclin dependent kinase like 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDKL5: cyclin dependent kinase like 5. Genes, record 6792. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6792

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Gene

Symbol
CDKL5
HGNC
Name
cyclin dependent kinase like 5
HGNC
NCBI Gene ID
6792
NCBI Gene
HGNC ID
HGNC:11411
HGNC
Ensembl
ENSG00000008086
NCBI Gene
Aliases
CFAP247, DEE2, EIEE2, ISSX, STK9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O76039Cyclin-dependent kinase-like 59603Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123994O76039Espacenet
US 12624354 B22026-05-123994O76039Espacenet
US 12570972 B22026-03-103994O76039Espacenet
US 12509680 B22025-12-303994O76039Espacenet
EP 4641201 A22025-10-2923629O76039Espacenet
JP 2025517969 A2025-06-1223629O76039Espacenet
WO 2025122548 A12025-06-126413O76039Espacenet
US 12281303 B22025-04-223994O76039Espacenet
WO 2025050032 A12025-03-061O76039Espacenet
WO 2025038796 A12025-02-206413O76039Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants741

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDKL5 papersNewest fiscal year
U01NS114312Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder212025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center132025
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt112025
R01MH101221Rare Mutations and Autism Spectrum Disorders72025
R01NS057819MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME32025
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders32025
T32GM007748Training Grant in Genetics32025
T32HG000035Interdisciplinary Training in Genome Sciences32025
U54NS092090Developmental Synaptopathies Associated with TSC, PTEN, SHANK3 and SynGAP1 Pathogenic Variants32025
DP5OD033357Long-read DNA and RNA sequencing to identify disease-causing genetic variation and streamline testing22025

1 to 10 of 741Source NIH's project files

See all 741 nih grants

Papers1,482

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Heterozygous Variant in the GABBR2 Gene in a Girl With Clinical Classic Rett Syndrome.Mol Genet Genomic Med202642802491PubTator, text miningPubMed
[Effectiveness and tolerability of ketogenic diet therapy in children with genetic developmental and epileptic encephalopathy onset within 2 years of age].Zhonghua Er Ke Za Zhi202642742013PubTator, text miningPubMed
TRACE: A Framework for Integrating Transcript Relevance Into ACMG/AMP Variant Interpretation.Hum Mutat202642707628PubTator, text miningPubMed
Associations between EEG measures and clinical severity in CDKL5 deficiency disorder.Clin Neurophysiol202642632229PubTator, text miningPubMed
CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder.Iran J Pharm Res202642488191PubTator, text miningPubMed
Cyclin-dependent kinases as signaling integrators in cancer: Structural evolution, functional plasticity, and drug discovery.Biochim Biophys Acta Mol Basis Dis202642435947PubTator, text miningPubMed
Clinical electrophysiological characteristics of cyclin-dependent kinase-like 5 gene induced developmental and epileptic encephalopathy (CDKL5-DEE).Epileptic Disord202642412596PubTator, text miningPubMed
Immune and clinicopathological features of molecularly defined prolactinoma subtypes.J Neurosurg202642361377PubTator, text miningPubMed
Comprehensive High-Depth Proteomic Analysis of Plasma Extracellular Vesicle-Containing Preparations in CDKL5 Deficiency Disorder.Biomedicines202642193287PubTator, text miningPubMed
From Sea to Therapy: Development and Analytical Control of Recombinant Human CDKL5 Production in the Marine Bacterium Pseudoalteromonas haloplanktis TAC125.Mar Drugs202642188286PubTator, text miningPubMed

1 to 10 of 1,482

See all 1,482 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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