Gene · 6795
AURKC: aurora kinase C
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AURKC: aurora kinase C. Genes, record 6795. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6795
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UQB9 | Aurora kinase C | 309 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4689071 A2 | 2026-02-11 | 12 | Q9UQB9 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3733 | Q9UQB9 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3733 | Q9UQB9 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7922 | Q9UQB9 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 4977 | Q9UQB9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 7922 | Q9UQB9 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 110893 | Q9UQB9 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 988 | Q9UQB9 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 4977 | Q9UQB9 | Espacenet |
| US 9962382 B2 | 2018-05-08 | 5 | Q9UQB9 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs10
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMG-900 | CHEMBL2140408 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| CENISERTIB | CHEMBL1967878 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| CYC-116 | CHEMBL482967 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| DANUSERTIB | CHEMBL402548 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| GSK-1070916 | CHEMBL1090479 | Serine/threonine-protein kinase Aurora-C inhibitor | INHIBITOR | ChEMBL |
| ILORASERTIB | CHEMBL1980297 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| MK-6592 | CHEMBL3545378 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| SNS-314 | CHEMBL482767 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| TOZASERTIB | CHEMBL572878 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
| TTP-607 | CHEMBL3545327 | Serine/threonine-protein kinase Aurora inhibitor | INHIBITOR | ChEMBL |
Trials16
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01380756 | AMG-900 | PHASE1 | ClinicalTrials.gov | |
| NCT01110473 | ILORASERTIB | PHASE1 | ClinicalTrials.gov | |
| NCT01097512 | CENISERTIB | PHASE1 | ClinicalTrials.gov | |
| NCT01080664 | CENISERTIB | PHASE1 | ClinicalTrials.gov | |
| NCT00939172 | TTP-607 | PHASE1 | ClinicalTrials.gov | |
| NCT00872300 | DANUSERTIB | PHASE2 | ClinicalTrials.gov | |
| NCT00858377 | AMG-900 | PHASE1 | ClinicalTrials.gov | |
| NCT00766324 | DANUSERTIB | PHASE2 | ClinicalTrials.gov | |
| NCT00560716 | CYC-116 | PHASE1 | ClinicalTrials.gov | |
| NCT00500006 | TOZASERTIB | PHASE1 | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsNIH grants497
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AURKC papers | Newest fiscal year |
|---|---|---|---|
| P30CA016359 | Cancer Center Support Grant | 18 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
| R35GM136340 | Signaling Mechanisms that Control Chromosome Segregation during Female Meiosis | 4 | 2025 |
| K12GM093854 | IRACDA at Rutgers: INSPIRE Postdoctoral Training Program | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| R01HD078641 | Genomics of spermatogenic impairment | 3 | 2025 |
| R01HD091331 | Understanding genetic risk for aneuploid conception | 3 | 2025 |
1 to 10 of 497Source NIH's project files
See all 497 nih grantsPapers944
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A CCNA1 Missense Variant Associated With Chromatid Non-Disjunction in Abnormal-Headed Sperm and Male Infertility. | Andrology | 2026 | 42746705 | PubTator, text mining | PubMed |
| Study on Two Carbazole-Based Difluoroboron Dyes With Aggregation-Induced Emission for Mechanofluorochromism, Ink-Free Writing, and Latent Fingerprint Imaging. | Luminescence | 2026 | 42609026 | PubTator, text mining | PubMed |
| Identification of a different DNA methylation pattern for pain related genes in children with intellectual disability: a cross-sectional study. | Ital J Pediatr | 2026 | 42152106 | PubTator, text mining | PubMed |
| Dysregulation of Aurora Kinases and AURKAIP1 Promoter Methylation as Potential Peripheral Diagnostic Biomarkers in Acute Myeloid Leukemia. | Curr Issues Mol Biol | 2026 | 42042038 | PubTator, text mining | PubMed |
| Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation. | Environ Int | 2026 | 41941847 | PubTator, text mining | PubMed |
| The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells. | Cell Death Dis | 2026 | 41876446 | PubTator, text mining | PubMed |
| A review of the research progress of miR-1237 in malignant tumors. | Medicine (Baltimore) | 2026 | 41824838 | PubTator, text mining | PubMed |
| In Vitro Anticancer Activity and In Silico Target Profiling of 5-(Piperazin-1-ylsulfonyl)-1,3-oxazole-4-carbonitriles. | Int J Mol Sci | 2026 | 41752072 | PubTator, text mining | PubMed |
| At the Crossroads of Data Justice and Data Capitalism: How Generative AI in Healthcare Mobilises Its Assemblages. | Sociol Health Illn | 2026 | 41612854 | PubTator, text mining | PubMed |
| Single-cell and machine learning approaches reveal METTL14-mediated autophagy via PI3K/AKT signaling in invasive PitNET. | Cancer Cell Int | 2026 | 41588537 | PubTator, text mining | PubMed |
1 to 10 of 944
See all 944 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6795
GET https://conductscience.org/api/genes/v1/6795/patents?page=2