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Gene · 6795

AURKC: aurora kinase C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AURKC: aurora kinase C. Genes, record 6795. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6795

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Gene

Symbol
AURKC
HGNC
Name
aurora kinase C
HGNC
NCBI Gene ID
6795
NCBI Gene
HGNC ID
HGNC:11391
HGNC
Ensembl
ENSG00000105146
NCBI Gene
Aliases
AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQB9Aurora kinase C3093Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4689071 A22026-02-1112Q9UQB9Espacenet
EP 4641201 A22025-10-293733Q9UQB9Espacenet
JP 2025517969 A2025-06-123733Q9UQB9Espacenet
JP 2025062604 A2025-04-147922Q9UQB9Espacenet
JP 2024123008 A2024-09-104977Q9UQB9Espacenet
US 11446398 B22022-09-207922Q9UQB9Espacenet
JP 2022524081 A2022-04-27110893Q9UQB9Espacenet
US 11078247 B22021-08-03988Q9UQB9Espacenet
US 10501513 B22019-12-104977Q9UQB9Espacenet
US 9962382 B22018-05-085Q9UQB9Espacenet

1 to 10 of 27

See all 27 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-900CHEMBL2140408Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
CENISERTIBCHEMBL1967878Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
CYC-116CHEMBL482967Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
DANUSERTIBCHEMBL402548Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
GSK-1070916CHEMBL1090479Serine/threonine-protein kinase Aurora-C inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
MK-6592CHEMBL3545378Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
SNS-314CHEMBL482767Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
TOZASERTIBCHEMBL572878Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
TTP-607CHEMBL3545327Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants497

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAURKC papersNewest fiscal year
P30CA016359Cancer Center Support Grant182025
P30CA006927Comprehensive Cancer Center Program at Fox Chase72025
P30CA016672Cancer Center Support Grant72025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
R35GM136340Signaling Mechanisms that Control Chromosome Segregation during Female Meiosis42025
K12GM093854IRACDA at Rutgers: INSPIRE Postdoctoral Training Program32025
P30CA021765Cancer Center Support Grant (CCSG)32025
R01HD078641Genomics of spermatogenic impairment32025
R01HD091331Understanding genetic risk for aneuploid conception32025

1 to 10 of 497Source NIH's project files

See all 497 nih grants

Papers944

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A CCNA1 Missense Variant Associated With Chromatid Non-Disjunction in Abnormal-Headed Sperm and Male Infertility.Andrology202642746705PubTator, text miningPubMed
Study on Two Carbazole-Based Difluoroboron Dyes With Aggregation-Induced Emission for Mechanofluorochromism, Ink-Free Writing, and Latent Fingerprint Imaging.Luminescence202642609026PubTator, text miningPubMed
Identification of a different DNA methylation pattern for pain related genes in children with intellectual disability: a cross-sectional study.Ital J Pediatr202642152106PubTator, text miningPubMed
Dysregulation of Aurora Kinases and AURKAIP1 Promoter Methylation as Potential Peripheral Diagnostic Biomarkers in Acute Myeloid Leukemia.Curr Issues Mol Biol202642042038PubTator, text miningPubMed
Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.Environ Int202641941847PubTator, text miningPubMed
The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells.Cell Death Dis202641876446PubTator, text miningPubMed
A review of the research progress of miR-1237 in malignant tumors.Medicine (Baltimore)202641824838PubTator, text miningPubMed
In Vitro Anticancer Activity and In Silico Target Profiling of 5-(Piperazin-1-ylsulfonyl)-1,3-oxazole-4-carbonitriles.Int J Mol Sci202641752072PubTator, text miningPubMed
At the Crossroads of Data Justice and Data Capitalism: How Generative AI in Healthcare Mobilises Its Assemblages.Sociol Health Illn202641612854PubTator, text miningPubMed
Single-cell and machine learning approaches reveal METTL14-mediated autophagy via PI3K/AKT signaling in invasive PitNET.Cancer Cell Int202641588537PubTator, text miningPubMed

1 to 10 of 944

See all 944 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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