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Gene · 6812

STXBP1: syntaxin binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. STXBP1: syntaxin binding protein 1. Genes, record 6812. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6812

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Gene

Symbol
STXBP1
HGNC
Name
syntaxin binding protein 1
HGNC
NCBI Gene ID
6812
NCBI Gene
HGNC ID
HGNC:11444
HGNC
Ensembl
ENSG00000136854
NCBI Gene
Aliases
DEE4, MUNC18-1, N-Sec1, NSEC1, P67, RBSEC1, UNC18, hUNC18, nSec1, rbSec1, unc-18A, unc18-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61764Syntaxin-binding protein 15941Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466261P61764Espacenet
WO 2025250031 A12025-12-042P61764Espacenet
EP 4650780 A22025-11-199290P61764Espacenet
EP 4641202 A22025-10-295579P61764Espacenet
JP 2025517970 A2025-06-129290P61764Espacenet
WO 2025122543 A12025-06-126413P61764Espacenet
KR 1020250017231 A2025-02-045579P61764Espacenet
JP 2024543001 A2024-11-1910P61764Espacenet
WO 2024229167 A12024-11-076413P61764Espacenet
KR 1020240099360 A2024-06-2810P61764Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,174

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSTXBP1 papersNewest fiscal year
U24NS120854ClinGen Expert Curation Panel for the Epilepsies102025
UL1TR001878Institutional Clinical and Translational Science Award102025
R01MH101221Rare Mutations and Autism Spectrum Disorders92025
R35GM131714Single-molecule studies of SNARE assembly and lipid transfer62025
P40OD010440Caenorhabditis Genetics Center52025
R01NS127830Subgroup delineation in genetic epilepsies and developmental brain disorders42025
R01NS131512A computational phenotyping approach to characterize neurogenetic disorders42025
R35GM126960Discovering protein networks underlying regulated exocytosis42025
T32HG000035Interdisciplinary Training in Genome Sciences42025
K12NS098482Child Neurologist Career Development Program32025

1 to 10 of 1,174Source NIH's project files

See all 1,174 nih grants

Papers1,814

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional profiling of STXBP1 missense variants using a novel dual-readout fluorometric assay.Epilepsia202642811883PubTator, text miningPubMed
Gene-specific machine learning model EpiPred identifies likely pathogenic variants in the epilepsy-related gene STXBP1.J Clin Invest202642752354PubTator, text miningPubMed
[Effectiveness and tolerability of ketogenic diet therapy in children with genetic developmental and epileptic encephalopathy onset within 2 years of age].Zhonghua Er Ke Za Zhi202642742013PubTator, text miningPubMed
Genomic Sequencing in Neonatal Encephalopathy and Suspected Hypoxic-Ischaemic Encephalopathy: A Systematic Review.Genes (Basel)202642650055PubTator, text miningPubMed
Tumor suppressor syntaxin binding protein 1 regulates alternative splicing of DNA repair genes related to radiation sensitivity in breast cancer cells.Oncol Lett202642631023PubTator, text miningPubMed
STXBP1 Variants Associated With Epilepsy With Variable Severity.CNS Neurosci Ther202642609058PubTator, text miningPubMed
Early infantile developmental and epileptic encephalopathy: clinical spectrum, diagnosis, outcomes, and evolving treatment strategies.Brain Dev202642607558PubTator, text miningPubMed
Diagnostic delay in infants with very early-onset rare and ultra-rare genetic epilepsies.Dev Med Child Neurol202642573089PubTator, text miningPubMed
Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site.Cell Mol Life Sci202642570027PubTator, text miningPubMed
Associations of Cortical and Subcortical White Matter Morphometric Abnormalities With Clinical and Genetic Findings in STXBP1 Encephalopathy.Neurol Genet202642559425PubTator, text miningPubMed

1 to 10 of 1,814

See all 1,814 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6812

GET https://conductscience.org/api/genes/v1/6812/patents?page=2