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Gene · 6839

SUV39H1: SUV39H1 histone lysine methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SUV39H1: SUV39H1 histone lysine methyltransferase. Genes, record 6839. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6839

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Gene

Symbol
SUV39H1
HGNC
Name
SUV39H1 histone lysine methyltransferase
HGNC
NCBI Gene ID
6839
NCBI Gene
HGNC ID
HGNC:11479
HGNC
Ensembl
ENSG00000101945
NCBI Gene
Aliases
H3-K9-HMTase 1, KMT1A, MG44, SUV39H
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43463Histone-lysine N-methyltransferase SUV39H14121Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026106462 A2026-06-292O43463Espacenet
EP 4650780 A22025-11-199814O43463Espacenet
JP 2025517970 A2025-06-129814O43463Espacenet
WO 2025052001 A12025-03-132O43463Espacenet
EP 4520334 A12025-03-122O43463Espacenet
JP 2025501272 A2025-01-1716O43463Espacenet
JP 2024123008 A2024-09-108594O43463Espacenet
US 11807852 B22023-11-0727O43463Espacenet
JP 2023535501 A2023-08-172O43463Espacenet
KR 1020230074713 A2023-05-312O43463Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,112

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSUV39H1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant172025
P30CA010815Consolidated Basic Cancer Research Program112025
P30CA016672Cancer Center Support Grant112025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology112025
P30AI027763UCSF-Bay Area Center for AIDS Research92025
P30CA076292Moffitt Cancer Center Support Grant82025
R01GM072805Epigenetic inheritance of heterochromatin82025
ZIABC010413Human Artificial Chromosomes for Cancer Research and Functional Genomics72025
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)62025
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin52025

1 to 10 of 2,112Source NIH's project files

See all 2,112 nih grants

Papers3,037

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development.Biochem Biophys Res Commun202642772177PubTator, text miningPubMed
Chaetocin Induces Ferroptosis in Cisplatin-Resistant Ovarian Cancer Cells Through Neddylation-Mediated TFRC Upregulation.Phytother Res202642734152PubTator, text miningPubMed
Nuclear amphiregulin and lamin A contribute to genomic stability and the response to replication stress via regulation of heterochromatin.Oncogene202642581070PubTator, text miningPubMed
Exploratory Transcriptomic Profiling of Vein Tissue from Diabetic Patients Undergoing Arteriovenous Fistula Creation for Hemodialysis.J Atheroscler Thromb202642557021PubTator, text miningPubMed
Single-cell and spatial transcriptomics reveal SUV39H1 as a master epigenetic driver of immunosuppressive niche and stemness in bladder cancer.Transl Oncol202642492366PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
Chromatin chronicles: Unlocking the therapeutic potential of histone modifiers in hepatocellular carcinoma.Med Oncol202642360649PubTator, text miningPubMed
Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response.Int J Biol Sci202642328454PubTator, text miningPubMed
Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription.Res Sq202642281995PubTator, text miningPubMed
Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.Signal Transduct Target Ther202642236690PubTator, text miningPubMed

1 to 10 of 3,037

See all 3,037 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6839

GET https://conductscience.org/api/genes/v1/6839/patents?page=2