Gene · 6839
SUV39H1: SUV39H1 histone lysine methyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SUV39H1: SUV39H1 histone lysine methyltransferase. Genes, record 6839. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6839
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43463 | Histone-lysine N-methyltransferase SUV39H1 | 412 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026106462 A | 2026-06-29 | 2 | O43463 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9814 | O43463 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9814 | O43463 | Espacenet |
| WO 2025052001 A1 | 2025-03-13 | 2 | O43463 | Espacenet |
| EP 4520334 A1 | 2025-03-12 | 2 | O43463 | Espacenet |
| JP 2025501272 A | 2025-01-17 | 16 | O43463 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8594 | O43463 | Espacenet |
| US 11807852 B2 | 2023-11-07 | 27 | O43463 | Espacenet |
| JP 2023535501 A | 2023-08-17 | 2 | O43463 | Espacenet |
| KR 1020230074713 A | 2023-05-31 | 2 | O43463 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,112
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SUV39H1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 17 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 11 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 8 | 2025 |
| R01GM072805 | Epigenetic inheritance of heterochromatin | 8 | 2025 |
| ZIABC010413 | Human Artificial Chromosomes for Cancer Research and Functional Genomics | 7 | 2025 |
| P30AI036219 | Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR) | 6 | 2025 |
| P01CA125066 | Discovery of Anticancer Agents of Diverse Natural Origin | 5 | 2025 |
1 to 10 of 2,112Source NIH's project files
See all 2,112 nih grantsPapers3,037
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development. | Biochem Biophys Res Commun | 2026 | 42772177 | PubTator, text mining | PubMed |
| Chaetocin Induces Ferroptosis in Cisplatin-Resistant Ovarian Cancer Cells Through Neddylation-Mediated TFRC Upregulation. | Phytother Res | 2026 | 42734152 | PubTator, text mining | PubMed |
| Nuclear amphiregulin and lamin A contribute to genomic stability and the response to replication stress via regulation of heterochromatin. | Oncogene | 2026 | 42581070 | PubTator, text mining | PubMed |
| Exploratory Transcriptomic Profiling of Vein Tissue from Diabetic Patients Undergoing Arteriovenous Fistula Creation for Hemodialysis. | J Atheroscler Thromb | 2026 | 42557021 | PubTator, text mining | PubMed |
| Single-cell and spatial transcriptomics reveal SUV39H1 as a master epigenetic driver of immunosuppressive niche and stemness in bladder cancer. | Transl Oncol | 2026 | 42492366 | PubTator, text mining | PubMed |
| CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks. | Nucleic Acids Res | 2026 | 42475683 | PubTator, text mining | PubMed |
| Chromatin chronicles: Unlocking the therapeutic potential of histone modifiers in hepatocellular carcinoma. | Med Oncol | 2026 | 42360649 | PubTator, text mining | PubMed |
| Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response. | Int J Biol Sci | 2026 | 42328454 | PubTator, text mining | PubMed |
| Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription. | Res Sq | 2026 | 42281995 | PubTator, text mining | PubMed |
| Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers. | Signal Transduct Target Ther | 2026 | 42236690 | PubTator, text mining | PubMed |
1 to 10 of 3,037
See all 3,037 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6839
GET https://conductscience.org/api/genes/v1/6839/patents?page=2