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Gene · 6844

VAMP2: vesicle associated membrane protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VAMP2: vesicle associated membrane protein 2. Genes, record 6844. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6844

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Gene

Symbol
VAMP2
HGNC
Name
vesicle associated membrane protein 2
HGNC
NCBI Gene ID
6844
NCBI Gene
HGNC ID
HGNC:12643
HGNC
Ensembl
ENSG00000220205
NCBI Gene
Aliases
NEDHAHM, SYB2, VAMP-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P63027Vesicle-associated membrane protein 21167Ensembl, GeneID, HGNC

Source UniProt

Patents104

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469647P63027Espacenet
EP 4650780 A22025-11-194947P63027Espacenet
JP 2025533447 A2025-10-0732P63027Espacenet
WO 2025196445 A12025-09-2525P63027Espacenet
JP 2025529142 A2025-09-045214P63027Espacenet
US 12371689 B22025-07-295214P63027Espacenet
US 12344634 B22025-07-019P63027Espacenet
JP 2025517970 A2025-06-124947P63027Espacenet
KR 1020250069908 A2025-05-2032P63027Espacenet
US 12209269 B22025-01-2817P63027Espacenet

1 to 10 of 104

See all 104 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
RIMABOTULINUMTOXINBCHEMBL1201569Vesicle-associated membrane protein 2 inhibitorINHIBITOR

Source ChEMBL

Trials15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05097079RIMABOTULINUMTOXINBPHASE3ClinicalTrials.gov
NCT04815967RIMABOTULINUMTOXINBPHASE2/PHASE3ClinicalTrials.gov
NCT04099667RIMABOTULINUMTOXINBPHASE2/PHASE3ClinicalTrials.gov
NCT03103074RIMABOTULINUMTOXINBClinicalTrials.gov
NCT02610868RIMABOTULINUMTOXINBPHASE32019-11-04ClinicalTrials.gov
NCT02212119RIMABOTULINUMTOXINBPHASE2ClinicalTrials.gov
NCT02002923RIMABOTULINUMTOXINBPHASE2ClinicalTrials.gov
NCT01994109RIMABOTULINUMTOXINBPHASE32019-08-15ClinicalTrials.gov
NCT01930604RIMABOTULINUMTOXINBPHASE2ClinicalTrials.gov
NCT00702754RIMABOTULINUMTOXINBPHASE42009-09-23ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

NIH grants1,964

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVAMP2 papersNewest fiscal year
R01MH061876Synaptotagmin C2B Domain as a Ca2+ Sensing Module142025
R01NS080833Biology and Engineering of Botulinum Neurotoxins.102025
P30DK034854Integrated Epithelial and Muscosal Biology82025
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt62025
P30CA068485Cancer Center Support Grant52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
R01AI093504Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning52025
R01MH070727Antidepressants and Intracellular Signaling Linked to BDNF52025
R35GM131714Single-molecule studies of SNARE assembly and lipid transfer52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,964Source NIH's project files

See all 1,964 nih grants

Papers2,700

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dual effect of α-synuclein disease variants on condensate formation.Nat Commun202642823411PubTator, text miningPubMed
Development of novel human monoclonal antibodies for botulinum neurotoxin type F subtype 1.Jpn J Infect Dis202642816359PubTator, text miningPubMed
Correction: Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer's disease and Parkinson's disease.Alzheimers Res Ther202642800866PubTator, text miningPubMed
Synaptobrevin-2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin-Dependent Pathway.J Neurochem202642725393PubTator, text miningPubMed
Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development.J Cell Biol202642704317PubTator, text miningPubMed
Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease.NPJ Parkinsons Dis202642649220PubTator, text miningPubMed
Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo.Nat Methods202642533122PubTator, text miningPubMed
Munc18 binds to and organizes membrane-bound acceptor Q-SNARE complexes in a fashion that depends on the membrane's lipid composition.bioRxiv202642523309PubTator, text miningPubMed
Value of synaptic proteins as biomarkers in amyotrophic lateral sclerosis.Brain Commun202642404435PubTator, text miningPubMed
SNAREopathy in Neurologic Disorders: From Synaptic Mechanisms to Genetic and Epigenetic Regulation.Neuroscientist202642403099PubTator, text miningPubMed

1 to 10 of 2,700

See all 2,700 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6844

GET https://conductscience.org/api/genes/v1/6844/patents?page=2