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SYK: spleen associated tyrosine kinase

1 protein, 73 patents, 15 drugs, 99 trials, 6,254 NIH grants and 12,009 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSYKHGNC
Namespleen associated tyrosine kinaseHGNC
NCBI Gene ID6850NCBI Gene
HGNC IDHGNC:11491HGNC
EnsemblENSG00000165025NCBI Gene
AliasesIMD82, p72-SykNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43405Tyrosine-protein kinase SYK63593Ensembl, GeneID, HGNCUniProt

Patents 73

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465318P43405Espacenet
JP 2026004568 A2026-01-1465321P43405Espacenet
EP 4667578 A22025-12-24248P43405Espacenet
JP 2025541700 A2025-12-23154P43405Espacenet
EP 4641201 A22025-10-299936P43405Espacenet
JP 2025131621 A2025-09-09248P43405Espacenet
JP 2025517969 A2025-06-129936P43405Espacenet
JP 2025509598 A2025-04-111P43405Espacenet
US 12215347 B22025-02-046P43405Espacenet
EP 4493188 A22025-01-221P43405Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CERDULATINIBCHEMBL4116008Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
ENTOSPLETINIBCHEMBL3265032Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
FOSTAMATINIBCHEMBL2103830Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
FOSTAMATINIB DISODIUMCHEMBL3989516Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
GUSACITINIBCHEMBL4594275Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
LANRAPLENIBCHEMBL3986824Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
MIVAVOTINIBCHEMBL3979920Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
MIVAVOTINIB CITRATECHEMBL4594253Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
PRT-2607CHEMBL3545138Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL
R-112CHEMBL515271Tyrosine-protein kinase SYK inhibitorINHIBITORChEMBL

Trials 99

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06757257FOSTAMATINIBClinicalTrials.gov
NCT06639724FOSTAMATINIBPHASE1ClinicalTrials.gov
NCT06564207FOSTAMATINIBPHASE2ClinicalTrials.gov
NCT06291415SOVLEPLENIBPHASE1ClinicalTrials.gov
NCT06238531GUSACITINIBPHASE1ClinicalTrials.gov
NCT06233110FOSTAMATINIBPHASE1ClinicalTrials.gov
NCT05904093FOSTAMATINIBPHASE1ClinicalTrials.gov
NCT05613296FOSTAMATINIBClinicalTrials.gov
NCT05593770FOSTAMATINIBPHASE2/PHASE32024-11-05ClinicalTrials.gov
NCT05509582FOSTAMATINIBPHASE2ClinicalTrials.gov

NIH grants 6254

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1092,025NIH's project files
P30CA008748Cancer Center Support Grant802,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)262,025NIH's project files
P30CA016058Cancer Center Support Grant222,025NIH's project files
ZIAHL002346Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy192,025NIH's project files
P30CA023168Cancer Center Support Grant182,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR152,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy152,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies142,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology142,025NIH's project files

Papers 12009

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42805985PubTator, text miningPubMed
42805106PubTator, text miningPubMed
42799830PubTator, text miningPubMed
42793865PubTator, text miningPubMed
42786847PubTator, text miningPubMed
42782312PubTator, text miningPubMed
42781103PubTator, text miningPubMed
42760486PubTator, text miningPubMed
42740889PubTator, text miningPubMed
42735731PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license