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Gene · 6857

SYT1: synaptotagmin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SYT1: synaptotagmin 1. Genes, record 6857. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6857

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Gene

Symbol
SYT1
HGNC
Name
synaptotagmin 1
HGNC
NCBI Gene ID
6857
NCBI Gene
HGNC ID
HGNC:11509
HGNC
Ensembl
ENSG00000067715
NCBI Gene
Aliases
BAGOS, P65, SVP65, SYT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21579Synaptotagmin-142224Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026079407 A2026-04-1622P21579Espacenet
US 12560619 B22026-02-2451P21579Espacenet
JP 2026004568 A2026-01-1466071P21579Espacenet
JP 2026004568 A2026-01-1466072P21579Espacenet
JP 2026004568 A2026-01-1466078P21579Espacenet
EP 4641201 A22025-10-291438P21579Espacenet
JP 2025533447 A2025-10-0728P21579Espacenet
WO 2025196445 A12025-09-2523P21579Espacenet
JP 2025529142 A2025-09-044552P21579Espacenet
US 12371689 B22025-07-294552P21579Espacenet

1 to 10 of 67

See all 67 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,238

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSYT1 papersNewest fiscal year
R01MH061876Synaptotagmin C2B Domain as a Ca2+ Sensing Module672025
P30CA008748Cancer Center Support Grant122025
P30DA018343Yale/NIDA Neuroproteomics Center122025
R01NS080833Biology and Engineering of Botulinum Neurotoxins.112025
P30DK034854Integrated Epithelial and Muscosal Biology92025
P30CA068485Cancer Center Support Grant82025
P40OD018537Bloomington Drosophila Stock Center at Indiana University82025
R01MH063105Molecular mechanisms of synaptic neurotransmitter release72025
P30DK045735Yale Diabetes Research Center62025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025

1 to 10 of 2,238Source NIH's project files

See all 2,238 nih grants

Papers3,871

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PAK4 exacerbates melanoma immunosuppression by promoting exosome release.Proc Natl Acad Sci U S A202642826135PubTator, text miningPubMed
A novel de novo multi-exon deletion of SYT1 in a child with Baker-Gordon syndrome.BMC Pediatr202642750022PubTator, text miningPubMed
Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity.Proc Natl Acad Sci U S A202642743279PubTator, text miningPubMed
Transcriptional Profiling of Botulinum Neurotoxin Type A-Related Molecular Components in Primary Human Schwann Cells.Toxins (Basel)202642646749PubTator, text miningPubMed
Tumor-neuronal hybrid programs reveal a spatially adaptive malignant state in glioblastoma.Front Oncol202642609318PubTator, text miningPubMed
Rapid metastatic progression of primary pulmonary synovial sarcoma despite guideline-concordant multimodal therapy: a case report.Front Oncol202642553211PubTator, text miningPubMed
Electrostatics and Local Aromatic Residues Govern Lipid Binding and Membrane Penetration of Synaptotagmin C2 Domains.bioRxiv202642523241PubTator, text miningPubMed
Maternal copper levels moderate the neuroprotective effect of zinc on early childhood development: evidence from a birth cohort and proteomic profiling.Front Nutr202642516235PubTator, text miningPubMed
Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.Mol Biomed202642455424PubTator, text miningPubMed
Analytical and clinical validation of a novel proximity extension assay-based plasma biomarker panel in a cohort of prevalent neurodegenerative dementias.Alzheimers Res Ther202642436533PubTator, text miningPubMed

1 to 10 of 3,871

See all 3,871 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6857

GET https://conductscience.org/api/genes/v1/6857/patents?page=2