Gene · 6865
TACR2: tachykinin receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TACR2: tachykinin receptor 2. Genes, record 6865. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6865
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P21452 | Substance-K receptor | 398 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66343 | P21452 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4571 | P21452 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4571 | P21452 | Espacenet |
| JP 2023506117 A | 2023-02-15 | 14 | P21452 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 86505 | P21452 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 938 | P21452 | Espacenet |
| KR 1020220084035 A | 2022-06-21 | 10 | P21452 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 189476 | P21452 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11270 | P21452 | Espacenet |
| WO 2021073742 A1 | 2021-04-22 | 10 | P21452 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials15
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02107196 | IBODUTANT | PHASE3 | 2016-09-27 | ClinicalTrials.gov |
| NCT01309009 | NEPADUTANT | PHASE2 | ClinicalTrials.gov | |
| NCT01303224 | IBODUTANT | PHASE2 | 2013-03-25 | ClinicalTrials.gov |
| NCT01258153 | NEPADUTANT | PHASE2 | 2015-06-10 | ClinicalTrials.gov |
| NCT00761007 | IBODUTANT | PHASE2 | 2010-10-01 | ClinicalTrials.gov |
| NCT00629551 | SAREDUTANT | PHASE3 | ClinicalTrials.gov | |
| NCT00531622 | SAREDUTANT | PHASE3 | ClinicalTrials.gov | |
| NCT00429260 | SAREDUTANT | PHASE3 | ClinicalTrials.gov | |
| NCT00417118 | SAREDUTANT | PHASE3 | ClinicalTrials.gov | |
| NCT00415142 | SAREDUTANT | PHASE3 | ClinicalTrials.gov |
1 to 10 of 15
See all 15 trialsNIH grants677
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TACR2 papers | Newest fiscal year |
|---|---|---|---|
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30DK116074 | Stanford Diabetes Research Center | 2 | 2025 |
| R01CA172310 | Novel Targeted Anticancer Agents from Marine Cyanobacteria | 2 | 2025 |
| R01DK119482 | Role of Urothelial Purinergic Signaling in Diabetic Bladder Dysfunction | 2 | 2025 |
| R37HD043341 | Towards Curative Therapies for Hypogonadotropic Diseases | 2 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 2 | 2025 |
| P20GM103423 | The Maine Biomedical Research Network (INBRE) | 1 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 677Source NIH's project files
See all 677 nih grantsPapers1,063
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated Computational Modeling Reveals a Structurally Plausible Transient Paclitaxel-NK2R Interaction. | Bioengineering (Basel) | 2026 | 42649842 | PubTator, text mining | PubMed |
| Substance P and PACAP activate dural mast cells through MRGPRX2, not NK1R or PAC1/VPAC receptors. | Cephalalgia | 2026 | 42627518 | PubTator, text mining | PubMed |
| Structural insights into neurokinin 2 receptor selectivity hold implications for obesity therapeutics. | Nat Struct Mol Biol | 2026 | 42399557 | PubTator, text mining | PubMed |
| Structurally defining neurokinin selectivity to improve NK2R agonists. | Nat Struct Mol Biol | 2026 | 42350667 | PubTator, text mining | PubMed |
| The Role of Gut Microbiota and Their Derived Metabolites in Chemotherapy-Induced Nausea and Vomiting in Ovarian Cancer. | Cancer Med | 2026 | 41925105 | PubTator, text mining | PubMed |
| Explainable drug side effect prediction in central neural system via biologically informed graph neural network. | Transl Psychiatry | 2026 | 41876492 | PubTator, text mining | PubMed |
| Detection of an Antagonist Bound to the Neurokinin a Receptor in Styrene-Maleic Acid Lipid Particles by 19F Ultrafast Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy. | Chembiochem | 2026 | 41869979 | PubTator, text mining | PubMed |
| Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications. | Neurooncol Adv | 2026 | 41768124 | PubTator, text mining | PubMed |
| An Update on the Correlation Between Neuroimmunomodulation, Photodynamic Therapy (PDT), and Wound Healing: The Role of Mast Cells. | Biomedicines | 2026 | 41751179 | PubTator, text mining | PubMed |
| Time-bin encoded quantum key distribution over 120 km with a telecom quantum dot source. | Light Sci Appl | 2026 | 41735250 | PubTator, text mining | PubMed |
1 to 10 of 1,063
See all 1,063 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6865
GET https://conductscience.org/api/genes/v1/6865/patents?page=2