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Gene · 6865

TACR2: tachykinin receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TACR2: tachykinin receptor 2. Genes, record 6865. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6865

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Gene

Symbol
TACR2
HGNC
Name
tachykinin receptor 2
HGNC
NCBI Gene ID
6865
NCBI Gene
HGNC ID
HGNC:11527
HGNC
Ensembl
ENSG00000075073
NCBI Gene
Aliases
NK2R, NKNAR, SKR, TAC2R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21452Substance-K receptor3986Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466343P21452Espacenet
JP 2025529142 A2025-09-044571P21452Espacenet
US 12371689 B22025-07-294571P21452Espacenet
JP 2023506117 A2023-02-1514P21452Espacenet
US 11446398 B22022-09-2086505P21452Espacenet
US 11400116 B22022-08-02938P21452Espacenet
KR 1020220084035 A2022-06-2110P21452Espacenet
JP 2022524081 A2022-04-27189476P21452Espacenet
US 11078247 B22021-08-0311270P21452Espacenet
WO 2021073742 A12021-04-2210P21452Espacenet

1 to 10 of 24

See all 24 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBODUTANTCHEMBL266125Neurokinin 2 receptor antagonistANTAGONISTChEMBL
NEPADUTANTCHEMBL1908318Neurokinin 2 receptor antagonistANTAGONISTChEMBL
SAREDUTANTCHEMBL308148Neurokinin 2 receptor antagonistANTAGONISTChEMBL

Trials15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02107196IBODUTANTPHASE32016-09-27ClinicalTrials.gov
NCT01309009NEPADUTANTPHASE2ClinicalTrials.gov
NCT01303224IBODUTANTPHASE22013-03-25ClinicalTrials.gov
NCT01258153NEPADUTANTPHASE22015-06-10ClinicalTrials.gov
NCT00761007IBODUTANTPHASE22010-10-01ClinicalTrials.gov
NCT00629551SAREDUTANTPHASE3ClinicalTrials.gov
NCT00531622SAREDUTANTPHASE3ClinicalTrials.gov
NCT00429260SAREDUTANTPHASE3ClinicalTrials.gov
NCT00417118SAREDUTANTPHASE3ClinicalTrials.gov
NCT00415142SAREDUTANTPHASE3ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

NIH grants677

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTACR2 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center32025
P30CA016086Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30DK116074Stanford Diabetes Research Center22025
R01CA172310Novel Targeted Anticancer Agents from Marine Cyanobacteria22025
R01DK119482Role of Urothelial Purinergic Signaling in Diabetic Bladder Dysfunction22025
R37HD043341Towards Curative Therapies for Hypogonadotropic Diseases22025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)22025
P20GM103423The Maine Biomedical Research Network (INBRE)12025
P30CA013148Comprehensive Cancer Center Support Grant12025

1 to 10 of 677Source NIH's project files

See all 677 nih grants

Papers1,063

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Computational Modeling Reveals a Structurally Plausible Transient Paclitaxel-NK2R Interaction.Bioengineering (Basel)202642649842PubTator, text miningPubMed
Substance P and PACAP activate dural mast cells through MRGPRX2, not NK1R or PAC1/VPAC receptors.Cephalalgia202642627518PubTator, text miningPubMed
Structural insights into neurokinin 2 receptor selectivity hold implications for obesity therapeutics.Nat Struct Mol Biol202642399557PubTator, text miningPubMed
Structurally defining neurokinin selectivity to improve NK2R agonists.Nat Struct Mol Biol202642350667PubTator, text miningPubMed
The Role of Gut Microbiota and Their Derived Metabolites in Chemotherapy-Induced Nausea and Vomiting in Ovarian Cancer.Cancer Med202641925105PubTator, text miningPubMed
Explainable drug side effect prediction in central neural system via biologically informed graph neural network.Transl Psychiatry202641876492PubTator, text miningPubMed
Detection of an Antagonist Bound to the Neurokinin a Receptor in Styrene-Maleic Acid Lipid Particles by 19F Ultrafast Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy.Chembiochem202641869979PubTator, text miningPubMed
Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications.Neurooncol Adv202641768124PubTator, text miningPubMed
An Update on the Correlation Between Neuroimmunomodulation, Photodynamic Therapy (PDT), and Wound Healing: The Role of Mast Cells.Biomedicines202641751179PubTator, text miningPubMed
Time-bin encoded quantum key distribution over 120 km with a telecom quantum dot source.Light Sci Appl202641735250PubTator, text miningPubMed

1 to 10 of 1,063

See all 1,063 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/6865/patents?page=2