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ADAM17: ADAM metallopeptidase domain 17

1 protein, 118 patents, 1 drug, 1 trial, 4,789 NIH grants and 9,480 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADAM17HGNC
NameADAM metallopeptidase domain 17HGNC
NCBI Gene ID6868NCBI Gene
HGNC IDHGNC:195HGNC
EnsemblENSG00000151694NCBI Gene
AliasesADAM18, CD156B, CSVP, HYPT16, NISBD, NISBD1, TACE, cSVPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P78536Disintegrin and metalloproteinase domain-containing protein 1782433Ensembl, GeneID, HGNCUniProt

Patents 118

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11502P78536Espacenet
EP 4650780 A22025-11-194659P78536Espacenet
EP 4641201 A22025-10-294227P78536Espacenet
JP 2025147176 A2025-10-06253P78536Espacenet
JP 2025529142 A2025-09-04265P78536Espacenet
JP 2025529142 A2025-09-045371P78536Espacenet
US 12371689 B22025-07-29265P78536Espacenet
US 12371689 B22025-07-295371P78536Espacenet
JP 2025517969 A2025-06-124227P78536Espacenet
JP 2025517970 A2025-06-124659P78536Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APRATASTATCHEMBL206815ADAM17 inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00095342APRATASTATPHASE2ClinicalTrials.gov

NIH grants 4789

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant272,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy172,025NIH's project files
P30CA016672Cancer Center Support Grant162,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies152,025NIH's project files
R01CA203348Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killing152,025NIH's project files
P30CA068485Cancer Center Support Grant142,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
P30CA047904Cancer Center Support Grant102,025NIH's project files
P50CA097190Head and Neck Cancer SPORE102,025NIH's project files

Papers 9480

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42803585PubTator, text miningPubMed
42786404PubTator, text miningPubMed
42785662PubTator, text miningPubMed
42778654PubTator, text miningPubMed
42776280PubTator, text miningPubMed
42774993PubTator, text miningPubMed
42770619PubTator, text miningPubMed
42737734PubTator, text miningPubMed
42714761PubTator, text miningPubMed
42698337PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license