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Gene · 688

KLF5: KLF transcription factor 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KLF5: KLF transcription factor 5. Genes, record 688. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/688

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Gene

Symbol
KLF5
HGNC
Name
KLF transcription factor 5
HGNC
NCBI Gene ID
688
NCBI Gene
HGNC ID
HGNC:6349
HGNC
Ensembl
ENSG00000102554
NCBI Gene
Aliases
BTEB2, CKLF, IKLF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13887Krueppel-like factor 54571Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0615219Q13887Espacenet
EP 4553154 A12025-05-147Q13887Espacenet
JP 2025028160 A2025-02-2815219Q13887Espacenet
KR 1020250010750 A2025-01-2115219Q13887Espacenet
JP 2024160262 A2024-11-13145Q13887Espacenet
KR 1020240158384 A2024-11-04145Q13887Espacenet
JP 2024534404 A2024-09-2089Q13887Espacenet
JP 2024109657 A2024-08-1415058Q13887Espacenet
WO 2024010085 A2024-01-117Q13887Espacenet
JP 2023114300 A2023-08-175Q13887Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,225

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLF5 papersNewest fiscal year
R01DK052230Regulation of Intestinal Epithelial Cell Proliferation322025
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant152025
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases112025
P30CA016520Abramson Cancer Center Support Grant82025
P30CA138292Winship Cancer Institute Cancer Center Support Grant82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant72025
P30CA016056Roswell Park Cancer Center Support Grant72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA016086Cancer Center Support Grant52025

1 to 10 of 2,225Source NIH's project files

See all 2,225 nih grants

Papers3,365

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular Mechanisms of Indoor Environmental Pollution tt-DDE-Induced Blood Pressure Elevation and the Protective Role of Human-Specific Gene CHRFAM7A.Environ Health (Wash)202642775181PubTator, text miningPubMed
KLF transcription factors in metabolic kidney disease: from podocyte protection to tubulointerstitial fibrosis.Int Urol Nephrol202642753072PubTator, text miningPubMed
KLF5-driven G6PD protects lung squamous cell carcinoma from ferroptosis by sustaining mitochondrial homeostasis and SLC7A11-dependent cystine uptake.Int Immunopharmacol202642748785PubTator, text miningPubMed
Erratum: Krüppel-like factor 5 promotes the progression of oral squamous cell carcinoma via the baculoviral IAP repeat containing 5 gene.Ann Transl Med202642719264PubTator, text miningPubMed
A recurrently perturbed 12-gene program marks drug-tolerant persister states across cancer types.Front Bioinform202642682804PubTator, text miningPubMed
PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses.Cell Syst202642664975PubTator, text miningPubMed
KLF5 Downregulation Links Impaired BNIP3-Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease.Adv Sci (Weinh)202642658612PubTator, text miningPubMed
Probucol inhibits palmitic acid-mediated renal calcium oxalate stone formation by targeting KLF5-PPARγ axis-mediated lipotoxicity.J Pharm Anal202642631108PubTator, text miningPubMed
Regulatory roles and translational potential of the Kruppel-like factor family in liver disease.ILIVER202642598083PubTator, text miningPubMed
Molecular Mechanism of TRIM16 Regulating Osteogenic Differentiation of Periodontal Ligament Stem Cells Under Inflammatory Microenvironment.Cell Biol Int202642559952PubTator, text miningPubMed

1 to 10 of 3,365

See all 3,365 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/688

GET https://conductscience.org/api/genes/v1/688/patents?page=2