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Gene · 6886

TAL1: TAL bHLH transcription factor 1, erythroid differentiation factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TAL1: TAL bHLH transcription factor 1, erythroid differentiation factor. Genes, record 6886. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6886

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Gene

Symbol
TAL1
HGNC
Name
TAL bHLH transcription factor 1, erythroid differentiation factor
HGNC
NCBI Gene ID
6886
NCBI Gene
HGNC ID
HGNC:11556
HGNC
Ensembl
ENSG00000162367
NCBI Gene
Aliases
SCL, TCL5, bHLHa17, tal-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17542T-cell acute lymphocytic leukemia protein 13312Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0615705P17542Espacenet
JP 2025147176 A2025-10-0616608P17542Espacenet
JP 2025028160 A2025-02-2815705P17542Espacenet
JP 2025028160 A2025-02-2816608P17542Espacenet
KR 1020250010750 A2025-01-2115705P17542Espacenet
KR 1020250010750 A2025-01-2116608P17542Espacenet
JP 2024123008 A2024-09-108610P17542Espacenet
JP 2024123008 A2024-09-108612P17542Espacenet
JP 2024109657 A2024-08-1415544P17542Espacenet
JP 2024109657 A2024-08-1416447P17542Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,325

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTAL1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)412025
P30CA008748Cancer Center Support Grant222025
R01CA096899Mechanism(s) of TAL1- and NOTCH1-mediated Leukemogenesis152025
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis132025
P30CA016672Cancer Center Support Grant122025
P30CA068485Cancer Center Support Grant122025
R01DK050107Transcriptional Control of Hemoglobin Synthesis and Erythrocyte Development122025
R01DK068634Hematopoietic Regulation via GATA Switches122025
R01DK054937Transcriptional Networks Controlling Erythroid Differentiation102025
R35CA197695Translating genomic discoveries to improved outcomes for high risk acute leukemia102025

1 to 10 of 2,325Source NIH's project files

See all 2,325 nih grants

Papers3,225

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications.Haematologica202642610420PubTator, text miningPubMed
TAL1 is indispensable in ETV2-primed human endothelial cell fate determination.Sci Adv202642585327PubTator, text miningPubMed
Dynamic expression of CD9 protein in T-cell acute lymphoblastic leukemia.Cancer Gene Ther202642576053PubTator, text miningPubMed
Bioinformatics identification of candidate biomarkers associated with T cell proliferation in atherosclerosis via WGCNA and machine learning.J Cardiothorac Surg202642464325PubTator, text miningPubMed
Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters.Mol Ther Nucleic Acids202642405279PubTator, text miningPubMed
Association between tumor genomic mutations and the risk of PD-1 inhibitor-induced hypophysitis: a retrospective cohort study.Front Endocrinol (Lausanne)202642339089PubTator, text miningPubMed
Single-cell mapping of regulatory DNA-protein interactions.Cell202642242226PubTator, text miningPubMed
An integrated multi-omics analysis reveals a core epigenetically-activated transcriptional network driving oncogenic signaling in acute myeloid leukemia.Discov Oncol202642217088PubTator, text miningPubMed
Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia.bioRxiv202642146694PubTator, text miningPubMed
Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities.Amino Acids202641957118PubTator, text miningPubMed

1 to 10 of 3,225

See all 3,225 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6886

GET https://conductscience.org/api/genes/v1/6886/patents?page=2