Gene · 6910
TBX5: T-box transcription factor 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TBX5: T-box transcription factor 5. Genes, record 6910. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6910
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99593 | T-box transcription factor TBX5 | 518 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents54
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026076236 A | 2026-05-11 | 7 | Q99593 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 66602 | Q99593 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 66604 | Q99593 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4656 | Q99593 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4226 | Q99593 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15725 | Q99593 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4226 | Q99593 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4656 | Q99593 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15725 | Q99593 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15725 | Q99593 | Espacenet |
1 to 10 of 54
See all 54 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,537
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TBX5 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 20 | 2025 |
| T32HL007381 | Cardiovascular Sciences Training Grant | 18 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 16 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 16 | 2025 |
| R01HL057181 | Cardiogenesis: Molecular Mechanisms | 13 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 10 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 10 | 2025 |
| T32HL069768 | Pre-doctoral Training Program in Integrative Vascular Biology | 10 | 2025 |
| ZIAHL006001 | Framingham Project/Levy | 10 | 2025 |
| ZIAAG007380 | CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective study | 8 | 2025 |
1 to 10 of 2,537Source NIH's project files
See all 2,537 nih grantsPapers2,892
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic loci responsible for atrioventricular block in children. | Front Cell Dev Biol | 2026 | 42798645 | PubTator, text mining | PubMed |
| Serum human trophoblast cell surface antigen and T-box protein 5 levels play a role in predicting adverse pregnancy outcomes in eclampsia. | J Med Biochem | 2026 | 42780781 | PubTator, text mining | PubMed |
| Atrial Flutter in Partially Anomalous Pulmonary Venous Return: Electrophysiological Insights in Holt-Oram Syndrome. | Pacing Clin Electrophysiol | 2026 | 42778323 | PubTator, text mining | PubMed |
| Deletion of the PDZ-Binding Motif of TAZ Protein Induces Myocardial Calcium Overload and Hypertrophy via the TBX5-MFN2 Signaling Axis. | FASEB J | 2026 | 42771491 | PubTator, text mining | PubMed |
| A Novel Pathogenic Frameshift Variant Associated With Holt-Oram Syndrome: A Case Report. | Case Rep Genet | 2026 | 42751140 | PubTator, text mining | PubMed |
| Successful radiofrequency catheter ablation of right-sided focal atrial tachycardia in a patient with Holt-Oram syndrome: a case report. | Front Cardiovasc Med | 2026 | 42683017 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Whole-transcriptome analysis reveals key transcriptional and noncoding RNA regulators of skeletal muscle satellite cell differentiation in quail. | Poult Sci | 2026 | 42617273 | PubTator, text mining | PubMed |
| Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity. | Postepy Kardiol Interwencyjnej | 2026 | 42598495 | PubTator, text mining | PubMed |
| Elongating human heart organoids recapitulate early cardiac morphogenesis and axial organization. | Dev Cell | 2026 | 42580346 | PubTator, text mining | PubMed |
1 to 10 of 2,892
See all 2,892 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6910
GET https://conductscience.org/api/genes/v1/6910/patents?page=2