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Gene · 6910

TBX5: T-box transcription factor 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TBX5: T-box transcription factor 5. Genes, record 6910. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6910

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Gene

Symbol
TBX5
HGNC
Name
T-box transcription factor 5
HGNC
NCBI Gene ID
6910
NCBI Gene
HGNC ID
HGNC:11604
HGNC
Ensembl
ENSG00000089225
NCBI Gene
Aliases
HOS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99593T-box transcription factor TBX55184Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026076236 A2026-05-117Q99593Espacenet
JP 2026004568 A2026-01-1466602Q99593Espacenet
JP 2026004568 A2026-01-1466604Q99593Espacenet
EP 4650780 A22025-11-194656Q99593Espacenet
EP 4641201 A22025-10-294226Q99593Espacenet
JP 2025147176 A2025-10-0615725Q99593Espacenet
JP 2025517969 A2025-06-124226Q99593Espacenet
JP 2025517970 A2025-06-124656Q99593Espacenet
JP 2025028160 A2025-02-2815725Q99593Espacenet
KR 1020250010750 A2025-01-2115725Q99593Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,537

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTBX5 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)202025
T32HL007381Cardiovascular Sciences Training Grant182025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal162025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL162025
R01HL057181Cardiogenesis: Molecular Mechanisms132025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling102025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs102025
T32HL069768Pre-doctoral Training Program in Integrative Vascular Biology102025
ZIAHL006001Framingham Project/Levy102025
ZIAAG007380CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective study82025

1 to 10 of 2,537Source NIH's project files

See all 2,537 nih grants

Papers2,892

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
Serum human trophoblast cell surface antigen and T-box protein 5 levels play a role in predicting adverse pregnancy outcomes in eclampsia.J Med Biochem202642780781PubTator, text miningPubMed
Atrial Flutter in Partially Anomalous Pulmonary Venous Return: Electrophysiological Insights in Holt-Oram Syndrome.Pacing Clin Electrophysiol202642778323PubTator, text miningPubMed
Deletion of the PDZ-Binding Motif of TAZ Protein Induces Myocardial Calcium Overload and Hypertrophy via the TBX5-MFN2 Signaling Axis.FASEB J202642771491PubTator, text miningPubMed
A Novel Pathogenic Frameshift Variant Associated With Holt-Oram Syndrome: A Case Report.Case Rep Genet202642751140PubTator, text miningPubMed
Successful radiofrequency catheter ablation of right-sided focal atrial tachycardia in a patient with Holt-Oram syndrome: a case report.Front Cardiovasc Med202642683017PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Whole-transcriptome analysis reveals key transcriptional and noncoding RNA regulators of skeletal muscle satellite cell differentiation in quail.Poult Sci202642617273PubTator, text miningPubMed
Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy Kardiol Interwencyjnej202642598495PubTator, text miningPubMed
Elongating human heart organoids recapitulate early cardiac morphogenesis and axial organization.Dev Cell202642580346PubTator, text miningPubMed

1 to 10 of 2,892

See all 2,892 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6910

GET https://conductscience.org/api/genes/v1/6910/patents?page=2