Gene · 6915
TBXA2R: thromboxane A2 receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TBXA2R: thromboxane A2 receptor. Genes, record 6915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6915
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P21731 | Thromboxane A2 receptor | 343 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67018 | P21731 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9840 | P21731 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 546 | P21731 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4625 | P21731 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4625 | P21731 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9840 | P21731 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 546 | P21731 | Espacenet |
| EP 4491229 A2 | 2025-01-15 | 293 | P21731 | Espacenet |
| WO 2024230934 A1 | 2024-11-14 | 418 | P21731 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 88628 | P21731 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| PICOTAMIDE | CHEMBL1257015 | Thromboxane A2 receptor inhibitor | INHIBITOR | ChEMBL |
| RAMATROBAN | CHEMBL361812 | Thromboxane A2 receptor antagonist | ANTAGONIST | ChEMBL |
| SERATRODAST | CHEMBL70972 | Thromboxane A2 receptor antagonist | ANTAGONIST | ChEMBL |
| TERBOGREL | CHEMBL281398 | Thromboxane A2 receptor antagonist | ANTAGONIST | ChEMBL |
| TERUTROBAN | CHEMBL2107786 | Thromboxane A2 receptor antagonist | ANTAGONIST | ChEMBL |
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05706454 | RAMATROBAN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT02223494 | TERBOGREL | PHASE2 | ClinicalTrials.gov | |
| NCT02223481 | TERBOGREL | PHASE2 | ClinicalTrials.gov | |
| NCT00311051 | RAMATROBAN | PHASE2/PHASE3 | ClinicalTrials.gov |
NIH grants678
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TBXA2R papers | Newest fiscal year |
|---|---|---|---|
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| UL1TR002243 | Vanderbilt Institute for Clinical and Translational Research (VICTR) | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 2 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 2 | 2025 |
| R01AI078908 | Control of Pulmonary Inflammation by Leukotriene E4 | 2 | 2025 |
| R01HL098032 | Omics, mice and men: Development of precision transfusion medicine | 2 | 2025 |
| R01HL101972 | Characterization of Coagulation Factor-platelet Interactions: Role of FXI | 2 | 2025 |
| T32HL007427 | SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES | 2 | 2025 |
| U19AI095219 | Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease | 2 | 2025 |
1 to 10 of 678Source NIH's project files
See all 678 nih grantsPapers1,393
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| New insights into flavonoid binding to the thromboxane A2 receptor. | Blood Vessel Thromb Hemost | 2026 | 42621423 | PubTator, text mining | PubMed |
| A Scoping Review of Emerging Treatments in the Pipeline for Idiopathic Pulmonary Fibrosis: Future Perspectives. | Biomedicines | 2026 | 42351721 | PubTator, text mining | PubMed |
| Pinolenic Acid Inhibits Prostanoid TP Receptor-Mediated Contraction in Porcine Coronary Arteries. | Biol Pharm Bull | 2026 | 42342366 | PubTator, text mining | PubMed |
| The mechanistic role of the thromboxane A2 receptor (TBXA2R) in non-small cell lung cancer (NSCLC). | Cancer Cell Int | 2026 | 42050515 | PubTator, text mining | PubMed |
| The p.T216R mutation of the thromboxane A2 receptor disrupts platelet function by selectively altering the G12/13 signaling pathway. | J Thromb Haemost | 2026 | 41990920 | PubTator, text mining | PubMed |
| Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke. | Curr Issues Mol Biol | 2026 | 41899465 | PubTator, text mining | PubMed |
| The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets. | Cells | 2026 | 41892342 | PubTator, text mining | PubMed |
| TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells. | Life Sci Alliance | 2026 | 41844278 | PubTator, text mining | PubMed |
| Regulatory roles of bioactive lipids in vascular homeostasis and remodeling. | Med Rev (2021) | 2026 | 41783891 | PubTator, text mining | PubMed |
| Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor. | Nat Commun | 2026 | 41730883 | PubTator, text mining | PubMed |
1 to 10 of 1,393
See all 1,393 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6915
GET https://conductscience.org/api/genes/v1/6915/patents?page=2