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Gene · 6915

TBXA2R: thromboxane A2 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TBXA2R: thromboxane A2 receptor. Genes, record 6915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6915

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Gene

Symbol
TBXA2R
HGNC
Name
thromboxane A2 receptor
HGNC
NCBI Gene ID
6915
NCBI Gene
HGNC ID
HGNC:11608
HGNC
Ensembl
ENSG00000006638
NCBI Gene
Aliases
BDPLT13, TXA2-R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21731Thromboxane A2 receptor3436Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467018P21731Espacenet
EP 4641201 A22025-10-299840P21731Espacenet
EP 4641202 A22025-10-29546P21731Espacenet
JP 2025529142 A2025-09-044625P21731Espacenet
US 12371689 B22025-07-294625P21731Espacenet
JP 2025517969 A2025-06-129840P21731Espacenet
KR 1020250017231 A2025-02-04546P21731Espacenet
EP 4491229 A22025-01-15293P21731Espacenet
WO 2024230934 A12024-11-14418P21731Espacenet
US 11446398 B22022-09-2088628P21731Espacenet

1 to 10 of 42

See all 42 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PICOTAMIDECHEMBL1257015Thromboxane A2 receptor inhibitorINHIBITORChEMBL
RAMATROBANCHEMBL361812Thromboxane A2 receptor antagonistANTAGONISTChEMBL
SERATRODASTCHEMBL70972Thromboxane A2 receptor antagonistANTAGONISTChEMBL
TERBOGRELCHEMBL281398Thromboxane A2 receptor antagonistANTAGONISTChEMBL
TERUTROBANCHEMBL2107786Thromboxane A2 receptor antagonistANTAGONISTChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05706454RAMATROBANPHASE2/PHASE3ClinicalTrials.gov
NCT02223494TERBOGRELPHASE2ClinicalTrials.gov
NCT02223481TERBOGRELPHASE2ClinicalTrials.gov
NCT00311051RAMATROBANPHASE2/PHASE3ClinicalTrials.gov

NIH grants678

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTBXA2R papersNewest fiscal year
P30CA068485Cancer Center Support Grant32025
UL1TR002243Vanderbilt Institute for Clinical and Translational Research (VICTR)32025
P30CA016672Cancer Center Support Grant22025
P30CA118100University of New Mexico Cancer Center Support Grant22025
P30EY008126Core Grant in Vision Research22025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E422025
R01HL098032Omics, mice and men: Development of precision transfusion medicine22025
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI22025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES22025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease22025

1 to 10 of 678Source NIH's project files

See all 678 nih grants

Papers1,393

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
New insights into flavonoid binding to the thromboxane A2 receptor.Blood Vessel Thromb Hemost202642621423PubTator, text miningPubMed
A Scoping Review of Emerging Treatments in the Pipeline for Idiopathic Pulmonary Fibrosis: Future Perspectives.Biomedicines202642351721PubTator, text miningPubMed
Pinolenic Acid Inhibits Prostanoid TP Receptor-Mediated Contraction in Porcine Coronary Arteries.Biol Pharm Bull202642342366PubTator, text miningPubMed
The mechanistic role of the thromboxane A2 receptor (TBXA2R) in non-small cell lung cancer (NSCLC).Cancer Cell Int202642050515PubTator, text miningPubMed
The p.T216R mutation of the thromboxane A2 receptor disrupts platelet function by selectively altering the G12/13 signaling pathway.J Thromb Haemost202641990920PubTator, text miningPubMed
Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke.Curr Issues Mol Biol202641899465PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.Life Sci Alliance202641844278PubTator, text miningPubMed
Regulatory roles of bioactive lipids in vascular homeostasis and remodeling.Med Rev (2021)202641783891PubTator, text miningPubMed
Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor.Nat Commun202641730883PubTator, text miningPubMed

1 to 10 of 1,393

See all 1,393 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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