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Gene · 6950

TCP1: t-complex 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TCP1: t-complex 1. Genes, record 6950. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6950

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Gene

Symbol
TCP1
HGNC
Name
t-complex 1
HGNC
NCBI Gene ID
6950
NCBI Gene
HGNC ID
HGNC:11655
HGNC
Ensembl
ENSG00000120438
NCBI Gene
Aliases
CCT-alpha, CCT1, CCTa, Ccta, D6S230E, IDDPMGS, TCP-1-alpha
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17987T-complex protein 1 subunit alpha55665Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067908 A2026-04-212P17987Espacenet
JP 2026004568 A2026-01-1466635P17987Espacenet
EP 4650780 A22025-11-195107P17987Espacenet
JP 2025517970 A2025-06-125107P17987Espacenet
JP 2025032204 A2025-03-1136998P17987Espacenet
EP 4461818 A22024-11-1336998P17987Espacenet
US 11708610 B22023-07-25766P17987Espacenet
US 11708610 B22023-07-25767P17987Espacenet
JP 2023058610 A2023-04-2536998P17987Espacenet
JP 2022191462 A2022-12-272P17987Espacenet

1 to 10 of 85

See all 85 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,050

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTCP1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
R01GM056433Protein Folding in the Eukaryotic Cytosol72025
P30CA016672Cancer Center Support Grant62025
P30CA091842Cancer Center Support Grant42025
R01AI032539Cell Biology of Reovirus Infection42025
P30CA016086Cancer Center Support Grant32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
T32CA009110Training in Areas Fundamental to Cancer Research32025
ZIANS003052Molecular Pathogenesis of Neoplasia32025

1 to 10 of 1,050Source NIH's project files

See all 1,050 nih grants

Papers1,592

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
From protection to progression: How CCT/TRiC shapes therapy-induced senescence in glioblastoma multiforme.Biochim Biophys Acta Mol Basis Dis202742624300PubTator, text miningPubMed
Differential Modulation of the DR5-JNK-PD-L1 Signaling Axis by TRiC/CCT Subunits CCT7 and CCT2 Shapes Tumor Immune Evasion in Lung Adenocarcinoma.Cells202642738906PubTator, text miningPubMed
CCT3 Enhances Lung Adenocarcinoma Progression by Promoting p53 Ubiquitination and Degradation.Medicina (Kaunas)202642654382PubTator, text miningPubMed
CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma.Genes Dis202642620170PubTator, text miningPubMed
PPP2R2C promotes aerobic glycolysis and mediates pemetrexed resistance in lung adenocarcinomas by upregulating TCP1-dependent protein folding of glycolytic enzymes.Respir Res202642464257PubTator, text miningPubMed
Serum and adipose tissue-derived extracellular vesicles as biomarker reservoirs in oesophageal adenocarcinoma.Sci Rep202642350602PubTator, text miningPubMed
Hybrid Feature Selection-Based Machine Learning and Deep Learning Framework for Biomarker Prediction From RNA-seq Data During Dengue Fever to Severe Dengue Progression.Evol Bioinform Online202642137783PubTator, text miningPubMed
Identification of RPL4 as a biomarker associated with disulfidptosis and arachidonic acid metabolism in breast cancer.Discov Oncol202642096008PubTator, text miningPubMed
Chaperonin in health and disease.Mol Biomed202641920440PubTator, text miningPubMed
Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation.Oncol Rep202641789667PubTator, text miningPubMed

1 to 10 of 1,592

See all 1,592 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6950

GET https://conductscience.org/api/genes/v1/6950/patents?page=2