Gene · 6950
TCP1: t-complex 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TCP1: t-complex 1. Genes, record 6950. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6950
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17987 | T-complex protein 1 subunit alpha | 556 | 65 | Ensembl, GeneID, HGNC |
Source UniProt
Patents85
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067908 A | 2026-04-21 | 2 | P17987 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 66635 | P17987 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5107 | P17987 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5107 | P17987 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36998 | P17987 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36998 | P17987 | Espacenet |
| US 11708610 B2 | 2023-07-25 | 766 | P17987 | Espacenet |
| US 11708610 B2 | 2023-07-25 | 767 | P17987 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 36998 | P17987 | Espacenet |
| JP 2022191462 A | 2022-12-27 | 2 | P17987 | Espacenet |
1 to 10 of 85
See all 85 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,050
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TCP1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R01GM056433 | Protein Folding in the Eukaryotic Cytosol | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 4 | 2025 |
| R01AI032539 | Cell Biology of Reovirus Infection | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| T32CA009110 | Training in Areas Fundamental to Cancer Research | 3 | 2025 |
| ZIANS003052 | Molecular Pathogenesis of Neoplasia | 3 | 2025 |
1 to 10 of 1,050Source NIH's project files
See all 1,050 nih grantsPapers1,592
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| From protection to progression: How CCT/TRiC shapes therapy-induced senescence in glioblastoma multiforme. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42624300 | PubTator, text mining | PubMed |
| Differential Modulation of the DR5-JNK-PD-L1 Signaling Axis by TRiC/CCT Subunits CCT7 and CCT2 Shapes Tumor Immune Evasion in Lung Adenocarcinoma. | Cells | 2026 | 42738906 | PubTator, text mining | PubMed |
| CCT3 Enhances Lung Adenocarcinoma Progression by Promoting p53 Ubiquitination and Degradation. | Medicina (Kaunas) | 2026 | 42654382 | PubTator, text mining | PubMed |
| CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma. | Genes Dis | 2026 | 42620170 | PubTator, text mining | PubMed |
| PPP2R2C promotes aerobic glycolysis and mediates pemetrexed resistance in lung adenocarcinomas by upregulating TCP1-dependent protein folding of glycolytic enzymes. | Respir Res | 2026 | 42464257 | PubTator, text mining | PubMed |
| Serum and adipose tissue-derived extracellular vesicles as biomarker reservoirs in oesophageal adenocarcinoma. | Sci Rep | 2026 | 42350602 | PubTator, text mining | PubMed |
| Hybrid Feature Selection-Based Machine Learning and Deep Learning Framework for Biomarker Prediction From RNA-seq Data During Dengue Fever to Severe Dengue Progression. | Evol Bioinform Online | 2026 | 42137783 | PubTator, text mining | PubMed |
| Identification of RPL4 as a biomarker associated with disulfidptosis and arachidonic acid metabolism in breast cancer. | Discov Oncol | 2026 | 42096008 | PubTator, text mining | PubMed |
| Chaperonin in health and disease. | Mol Biomed | 2026 | 41920440 | PubTator, text mining | PubMed |
| Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation. | Oncol Rep | 2026 | 41789667 | PubTator, text mining | PubMed |
1 to 10 of 1,592
See all 1,592 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6950
GET https://conductscience.org/api/genes/v1/6950/patents?page=2