Gene · 699
BUB1: BUB1 mitotic checkpoint serine/threonine kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BUB1: BUB1 mitotic checkpoint serine/threonine kinase. Genes, record 699. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/699
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43683 | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 1,085 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39294 | O43683 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3698 | O43683 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4782 | O43683 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3698 | O43683 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10037 | O43683 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4782 | O43683 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 10037 | O43683 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 656 | O43683 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 113008 | O43683 | Espacenet |
| JP 2020062004 A | 2020-04-23 | 1031 | O43683 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,780
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BUB1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 23 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 17 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 9 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 8 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 1,780Source NIH's project files
See all 1,780 nih grantsPapers3,725
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Insight into Essential and Complex Autism Spectrum Disorders: Clinical Characteristics, Chromosomal Microarray Analysis, and Risk Factors. | Genes (Basel) | 2026 | 42792940 | PubTator, text mining | PubMed |
| BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer. | Biomedicines | 2026 | 42792682 | PubTator, text mining | PubMed |
| Immune cell enrichment characteristics and related key genes in intrauterine adhesion: insights from RNA-sequencing analysis. | Syst Biol Reprod Med | 2026 | 42763899 | PubTator, text mining | PubMed |
| Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India. | Front Immunol | 2026 | 42756106 | PubTator, text mining | PubMed |
| System level identification and multidimensional analysis of hub genes reveal complex regulatory networks underlying human iPSC differentiation into motor neurons. | Biochem Biophys Rep | 2026 | 42630798 | PubTator, text mining | PubMed |
| BUB1 regulates cell proliferation and apoptosis in cervical cancer by AKT signaling and autophagosome-lysosome fusion via ACTN1. | iScience | 2026 | 42602342 | PubTator, text mining | PubMed |
| Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays. | Front Oncol | 2026 | 42524029 | PubTator, text mining | PubMed |
| Epilepsy and Intellectual Disability in a Boy with a 2q13 Microdeletion Affecting the BUB1 Gene. | Pediatr Rep | 2026 | 42496474 | PubTator, text mining | PubMed |
| Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis. | Biomedicine (Taipei) | 2026 | 42483440 | PubTator, text mining | PubMed |
| Transcriptomics-driven non-invasive liquid biopsy for diagnosing peritoneal lavage cytology-positive gastric cancer. | NPJ Precis Oncol | 2026 | 42457866 | PubTator, text mining | PubMed |
1 to 10 of 3,725
See all 3,725 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/699
GET https://conductscience.org/api/genes/v1/699/patents?page=2