Gene · 6996
TDG: thymine DNA glycosylase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TDG: thymine DNA glycosylase. Genes, record 6996. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6996
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13569 | G/T mismatch-specific thymine DNA glycosylase | 410 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12624353 B2 | 2026-05-12 | 3872 | Q13569 | Espacenet |
| US 12624354 B2 | 2026-05-12 | 3872 | Q13569 | Espacenet |
| US 12570972 B2 | 2026-03-10 | 3872 | Q13569 | Espacenet |
| US 12509680 B2 | 2025-12-30 | 3872 | Q13569 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10972 | Q13569 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11376 | Q13569 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11376 | Q13569 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10972 | Q13569 | Espacenet |
| US 12281303 B2 | 2025-04-22 | 3872 | Q13569 | Espacenet |
| JP 2024542790 A | 2024-11-15 | 202 | Q13569 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,461
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TDG papers | Newest fiscal year |
|---|---|---|---|
| R01HG006827 | Labeling and sequencing of 5hmC and 5mC in DNA-Renewal | 23 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 14 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R35CA210043 | The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancer | 6 | 2025 |
| R35ES031638 | Watching cooperative interactions between base and nucleotide excision repair proteins | 6 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 5 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 5 | 2025 |
| R01GM102362 | Molecular Mechanisms for DNA Damage Processing by Transcription Machinery | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
1 to 10 of 1,461Source NIH's project files
See all 1,461 nih grantsPapers2,121
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells. | Nat Commun | 2026 | 42806035 | PubTator, text mining | PubMed |
| Robust excision of different purine lesions by homologs thymine DNA glycosylase and mismatch-specific uracil DNA-glycosylase. | J Biol Chem | 2026 | 42595112 | PubTator, text mining | PubMed |
| Luteolin reverses chemoresistance in colorectal cancer cells via TET1/TDG-dependent epigenetic repression of β-catenin. | Food Chem Toxicol | 2026 | 42497930 | PubTator, text mining | PubMed |
| Positive TAZ-TDG feedback loop drives proneural-to-mesenchymal transition to promote glioblastoma progression. | J Transl Med | 2026 | 42399932 | PubTator, text mining | PubMed |
| Changes in active DNA demethylation pathway components during neoadjuvant chemotherapy and their prognostic significance in breast cancer. | Breast Cancer Res | 2026 | 42316271 | PubTator, text mining | PubMed |
| Investigation of DNA repair-related lncRNA-p5549 expression in patients with obesity undergoing bariatric surgery. | Diabetol Metab Syndr | 2026 | 42298630 | PubTator, text mining | PubMed |
| Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic. | Nat Commun | 2026 | 42251035 | PubTator, text mining | PubMed |
| Pan-Cancer Landscape of Thymine DNA Glycosylase and Its Potential Role in Lung Adenocarcinoma. | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | 2026 | 42136331 | PubTator, text mining | PubMed |
| Base excision repair hierarchy in eukaryotes: Intrinsically disordered region-mediated regulation of genomic surveillance and assembly dynamics. | Curr Opin Struct Biol | 2026 | 42127749 | PubTator, text mining | PubMed |
| A spatiotemporal transcriptomic atlas of porcine (Sus scrofa) female early gonadal development. | Commun Biol | 2026 | 41906042 | PubTator, text mining | PubMed |
1 to 10 of 2,121
See all 2,121 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6996
GET https://conductscience.org/api/genes/v1/6996/patents?page=2