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Gene · 6996

TDG: thymine DNA glycosylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TDG: thymine DNA glycosylase. Genes, record 6996. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6996

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Gene

Symbol
TDG
HGNC
Name
thymine DNA glycosylase
HGNC
NCBI Gene ID
6996
NCBI Gene
HGNC ID
HGNC:11700
HGNC
Ensembl
ENSG00000139372
NCBI Gene
Aliases
hTDG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13569G/T mismatch-specific thymine DNA glycosylase41021Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123872Q13569Espacenet
US 12624354 B22026-05-123872Q13569Espacenet
US 12570972 B22026-03-103872Q13569Espacenet
US 12509680 B22025-12-303872Q13569Espacenet
EP 4650780 A22025-11-1910972Q13569Espacenet
EP 4641201 A22025-10-2911376Q13569Espacenet
JP 2025517969 A2025-06-1211376Q13569Espacenet
JP 2025517970 A2025-06-1210972Q13569Espacenet
US 12281303 B22025-04-223872Q13569Espacenet
JP 2024542790 A2024-11-15202Q13569Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,461

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTDG papersNewest fiscal year
R01HG006827Labeling and sequencing of 5hmC and 5mC in DNA-Renewal232025
P01CA092584Structural Cell Biology of DNA Repair Machines142025
P30CA006927Comprehensive Cancer Center Program at Fox Chase132025
P30CA008748Cancer Center Support Grant102025
R35CA210043The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancer62025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins62025
P30CA016086Cancer Center Support Grant52025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant52025
R01GM102362Molecular Mechanisms for DNA Damage Processing by Transcription Machinery52025
P30CA006973Regional Oncology Research Center42025

1 to 10 of 1,461Source NIH's project files

See all 1,461 nih grants

Papers2,121

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells.Nat Commun202642806035PubTator, text miningPubMed
Robust excision of different purine lesions by homologs thymine DNA glycosylase and mismatch-specific uracil DNA-glycosylase.J Biol Chem202642595112PubTator, text miningPubMed
Luteolin reverses chemoresistance in colorectal cancer cells via TET1/TDG-dependent epigenetic repression of β-catenin.Food Chem Toxicol202642497930PubTator, text miningPubMed
Positive TAZ-TDG feedback loop drives proneural-to-mesenchymal transition to promote glioblastoma progression.J Transl Med202642399932PubTator, text miningPubMed
Changes in active DNA demethylation pathway components during neoadjuvant chemotherapy and their prognostic significance in breast cancer.Breast Cancer Res202642316271PubTator, text miningPubMed
Investigation of DNA repair-related lncRNA-p5549 expression in patients with obesity undergoing bariatric surgery.Diabetol Metab Syndr202642298630PubTator, text miningPubMed
Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic.Nat Commun202642251035PubTator, text miningPubMed
Pan-Cancer Landscape of Thymine DNA Glycosylase and Its Potential Role in Lung Adenocarcinoma.Zhongguo Yi Xue Ke Xue Yuan Xue Bao202642136331PubTator, text miningPubMed
Base excision repair hierarchy in eukaryotes: Intrinsically disordered region-mediated regulation of genomic surveillance and assembly dynamics.Curr Opin Struct Biol202642127749PubTator, text miningPubMed
A spatiotemporal transcriptomic atlas of porcine (Sus scrofa) female early gonadal development.Commun Biol202641906042PubTator, text miningPubMed

1 to 10 of 2,121

See all 2,121 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6996

GET https://conductscience.org/api/genes/v1/6996/patents?page=2