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Gene · 6998

CRIPTO3: cripto, EGF-CFC family member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRIPTO3: cripto, EGF-CFC family member 3. Genes, record 6998. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6998

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Gene

Symbol
CRIPTO3
HGNC
Name
cripto, EGF-CFC family member 3
HGNC
NCBI Gene ID
6998
NCBI Gene
HGNC ID
HGNC:11703
HGNC
Ensembl
ENSG00000225366
NCBI Gene
Aliases
CR-3, CRIPTO-3, TDGF1, TDGF1P3, TDGF2, TDGF3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51864Protein CRIPTO31880Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 11400116 B22022-08-027466P51864Espacenet
US 8673303 B22014-03-182P51864Espacenet
US 8586006 B22013-11-1955421P51864Espacenet
US 8586006 B22013-11-1955422P51864Espacenet
JP 2013172712 A2013-09-05117P51864Espacenet
JP 2013140167 A2013-07-18117P51864Espacenet
US 8349324 B22013-01-082P51864Espacenet
US 8021661 B22011-09-207P51864Espacenet
US 8003763 B22011-08-232P51864Espacenet
EP 2316486 A22011-05-042P51864Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,094

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRIPTO3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
R01HL063199The role of beta 2 integrins in macrophage fusion82025
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology72025
R01DK084195Translating oral CD11b agonist as a novel therapeutic for lupus nephritis62025
ZIABC010440Protein Structure, Stability, and Amyloid Formation62025
ZIABC010441Biomolecular Recognition and Binding Mechanisms62025
P30CA014195Cancer Center Support Grant (CCSG)52025
ZIAHL006222The role of the intracellular complement system - the complosome - in monocytes52025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025

1 to 10 of 2,094Source NIH's project files

See all 2,094 nih grants

Papers3,187

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Microglial GPR56 in synaptic pruning: mechanisms, comparative receptor biology, and context-dependent roles in brain disorders.Biochim Biophys Acta Mol Cell Res202642826818PubTator, text miningPubMed
Complement-mediated synaptic loss in inflammatory depression: mechanisms and therapeutic prospects.Brain Behav Immun202642800570PubTator, text miningPubMed
Neuroimmune Dysregulation and Synaptic Pruning in Autism Spectrum Disorder.Biology (Basel)202642737971PubTator, text miningPubMed
Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Mol Biomed202642714778PubTator, text miningPubMed
The complement system in the pathophysiology and treatment of depression: From synaptic pruning to pharmacological targeting.Pharmacol Res202642668072PubTator, text miningPubMed
Range-Wide Geographic Variation of Major Gene Resistance (Cr3) to White Pine Blister Rust in Pinus strobiformis (Southwestern White Pine).Phytopathology202642571661PubTator, text miningPubMed
Structural characterization and immunomodulatory activity of sulfated polysaccharides from the green microalgae Tetraselmis suecica.Fitoterapia202642486285PubTator, text miningPubMed
Complement dysregulation during the early phases of synucleinopathy.Acta Neuropathol202642477211PubTator, text miningPubMed
NMR investigation of conformational heterogeneity in FOXO4 CR2C binding to the MLL site of CBP KIX.J Magn Reson202642472485PubTator, text miningPubMed
Injectable Hydrogel-Based Delivery of Soluble Cripto Protein Enhances Repair After Skeletal Muscle Injury.ACS Biomater Sci Eng202642284448PubTator, text miningPubMed

1 to 10 of 3,187

See all 3,187 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6998

GET https://conductscience.org/api/genes/v1/6998/patents?page=2