ConductScience.org, home

Library / Genes

TDO2: tryptophan 2,3-dioxygenase

1 protein, 46 patents, 0 drugs, 0 trials, 2,245 NIH grants and 6,018 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTDO2HGNC
Nametryptophan 2,3-dioxygenaseHGNC
NCBI Gene ID6999NCBI Gene
HGNC IDHGNC:11708HGNC
EnsemblENSG00000151790NCBI Gene
AliasesHYPTRP, TDO, TO, TPH2, TRPONCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48775Tryptophan 2,3-dioxygenase40622Ensembl, GeneID, HGNCUniProt

Patents 46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4750891 A12026-06-03118P48775Espacenet
JP 2026004568 A2026-01-1468404P48775Espacenet
EP 4650780 A22025-11-1916348P48775Espacenet
EP 4641201 A22025-10-2920065P48775Espacenet
WO 2025163323 A12025-08-075P48775Espacenet
JP 2025517969 A2025-06-1220065P48775Espacenet
JP 2025517970 A2025-06-1216348P48775Espacenet
JP 2025508467 A2025-03-26221P48775Espacenet
JP 2024528983 A2024-08-0110P48775Espacenet
EP 4384611 A22024-06-19118P48775Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2245

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30DK026743UCSF Liver Center102,025NIH's project files
R01GM108988Heme-Dependent Chemistry in Aromatic Oxidation92,025NIH's project files
R01NS097851IDO1 and Immunotolerance in Glioblastoma82,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT72,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant72,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30CA086862Cancer Center Support Grant62,025NIH's project files
P30CA093373Cancer Center Support Grant P3052,025NIH's project files

Papers 6018

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42769543PubTator, text miningPubMed
42739021PubTator, text miningPubMed
42737416PubTator, text miningPubMed
42730796PubTator, text miningPubMed
42715685PubTator, text miningPubMed
42713131PubTator, text miningPubMed
42670920PubTator, text miningPubMed
42589213PubTator, text miningPubMed
42571168PubTator, text miningPubMed
42564398PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license