Gene · 70
ACTC1: actin alpha cardiac muscle 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACTC1: actin alpha cardiac muscle 1. Genes, record 70. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/70
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P68032 | Actin, alpha cardiac muscle 1 | 377 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents91
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4663754 A2 | 2025-12-17 | 11 | P68032 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3427 | P68032 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3006 | P68032 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3006 | P68032 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3427 | P68032 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1503 | P68032 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24021 | P68032 | Espacenet |
| JP 2025013347 A | 2025-01-24 | 114 | P68032 | Espacenet |
| US 12201675 B2 | 2025-01-21 | 114 | P68032 | Espacenet |
| JP 2025003953 A | 2025-01-14 | 114 | P68032 | Espacenet |
1 to 10 of 91
See all 91 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,201
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACTC1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL132401 | Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30AR074990 | UW Center for Translational Muscle Research | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| R01AR064327 | Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs | 3 | 2025 |
| R01HL105826 | Fast myosin binding protein-C and cardiac contractility in heart failure | 3 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 3 | 2025 |
| T32GM007526 | Medical Genetics Research Fellowship Program | 3 | 2025 |
| ZIAHG200359 | Genomic Ascertainment - Molecular and Genetic Aspects | 3 | 2025 |
1 to 10 of 1,201Source NIH's project files
See all 1,201 nih grantsPapers1,745
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity. | Nat Commun | 2026 | 42697879 | PubTator, text mining | PubMed |
| Two Novel ACTC1 Variants Cause Arthrogryposis Multiplex Congenita. | Clin Genet | 2026 | 42458772 | PubTator, text mining | PubMed |
| Genetic insights into sporadic patent ductus arteriosus: the role of ACTC1 promoter variants. | Pediatr Res | 2026 | 42315598 | PubTator, text mining | PubMed |
| Steroidogenesis is associated with bladder cancer progression via reprogramming the metabolic landscape of the tumor immune microenvironment. | Discov Oncol | 2026 | 42310229 | PubTator, text mining | PubMed |
| Identification and analysis of endoplasmic reticulum stress-related biomarkers in chronic sinusitis with nasal polyps using bioinformatics approaches. | Medicine (Baltimore) | 2026 | 42299589 | PubTator, text mining | PubMed |
| Histone Deacetylase 7 protects against pathologic cardiac hypertrophy. | J Mol Cell Cardiol | 2026 | 42250622 | PubTator, text mining | PubMed |
| Placental transcriptome profiling and immune signature differences in pregnancies with and without gestational diabetes mellitus: An observational study. | Medicine (Baltimore) | 2026 | 42175401 | PubTator, text mining | PubMed |
| Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry. | J Am Coll Cardiol | 2026 | 42159538 | PubTator, text mining | PubMed |
| Population-Based Analysis of Rare Genetic Variants in Sudden Cardiac Arrest. | JACC Clin Electrophysiol | 2026 | 42159526 | PubTator, text mining | PubMed |
| Salivary protein profile of PLHIV on long-term antiretroviral therapy suggests latent reservoir and immune exhaustion. | Arch Oral Biol | 2026 | 42155959 | PubTator, text mining | PubMed |
1 to 10 of 1,745
See all 1,745 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/70
GET https://conductscience.org/api/genes/v1/70/patents?page=2