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Gene · 70

ACTC1: actin alpha cardiac muscle 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACTC1: actin alpha cardiac muscle 1. Genes, record 70. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/70

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Gene

Symbol
ACTC1
HGNC
Name
actin alpha cardiac muscle 1
HGNC
NCBI Gene ID
70
NCBI Gene
HGNC ID
HGNC:143
HGNC
Ensembl
ENSG00000159251
NCBI Gene
Aliases
ACTC, ASD5, CMD1R, CMH11, LVNC4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P68032Actin, alpha cardiac muscle 137716Ensembl, GeneID, HGNC

Source UniProt

Patents91

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4663754 A22025-12-1711P68032Espacenet
EP 4650780 A22025-11-193427P68032Espacenet
EP 4641201 A22025-10-293006P68032Espacenet
JP 2025517969 A2025-06-123006P68032Espacenet
JP 2025517970 A2025-06-123427P68032Espacenet
JP 2025062604 A2025-04-141503P68032Espacenet
JP 2025032204 A2025-03-1124021P68032Espacenet
JP 2025013347 A2025-01-24114P68032Espacenet
US 12201675 B22025-01-21114P68032Espacenet
JP 2025003953 A2025-01-14114P68032Espacenet

1 to 10 of 91

See all 91 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,201

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACTC1 papersNewest fiscal year
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations62025
P30CA008748Cancer Center Support Grant52025
P30AR074990UW Center for Translational Muscle Research32025
P30CA016086Cancer Center Support Grant32025
P30CA076292Moffitt Cancer Center Support Grant32025
R01AR064327Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs32025
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure32025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling32025
T32GM007526Medical Genetics Research Fellowship Program32025
ZIAHG200359Genomic Ascertainment - Molecular and Genetic Aspects32025

1 to 10 of 1,201Source NIH's project files

See all 1,201 nih grants

Papers1,745

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.Nat Commun202642697879PubTator, text miningPubMed
Two Novel ACTC1 Variants Cause Arthrogryposis Multiplex Congenita.Clin Genet202642458772PubTator, text miningPubMed
Genetic insights into sporadic patent ductus arteriosus: the role of ACTC1 promoter variants.Pediatr Res202642315598PubTator, text miningPubMed
Steroidogenesis is associated with bladder cancer progression via reprogramming the metabolic landscape of the tumor immune microenvironment.Discov Oncol202642310229PubTator, text miningPubMed
Identification and analysis of endoplasmic reticulum stress-related biomarkers in chronic sinusitis with nasal polyps using bioinformatics approaches.Medicine (Baltimore)202642299589PubTator, text miningPubMed
Histone Deacetylase 7 protects against pathologic cardiac hypertrophy.J Mol Cell Cardiol202642250622PubTator, text miningPubMed
Placental transcriptome profiling and immune signature differences in pregnancies with and without gestational diabetes mellitus: An observational study.Medicine (Baltimore)202642175401PubTator, text miningPubMed
Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.J Am Coll Cardiol202642159538PubTator, text miningPubMed
Population-Based Analysis of Rare Genetic Variants in Sudden Cardiac Arrest.JACC Clin Electrophysiol202642159526PubTator, text miningPubMed
Salivary protein profile of PLHIV on long-term antiretroviral therapy suggests latent reservoir and immune exhaustion.Arch Oral Biol202642155959PubTator, text miningPubMed

1 to 10 of 1,745

See all 1,745 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/70

GET https://conductscience.org/api/genes/v1/70/patents?page=2