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Gene · 7001

PRDX2: peroxiredoxin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRDX2: peroxiredoxin 2. Genes, record 7001. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7001

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Gene

Symbol
PRDX2
HGNC
Name
peroxiredoxin 2
HGNC
NCBI Gene ID
7001
NCBI Gene
HGNC ID
HGNC:9353
HGNC
Ensembl
ENSG00000167815
NCBI Gene
Aliases
HEL-S-2a, MGC4104, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32119Peroxiredoxin-21987Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-038P32119Espacenet
EP 4650780 A22025-11-194084P32119Espacenet
WO 2025163153 A22025-08-0722P32119Espacenet
JP 2025517970 A2025-06-124084P32119Espacenet
US 12133879 B22024-11-058P32119Espacenet
US 11872193 B22024-01-168P32119Espacenet
US 11860162 B22024-01-021542P32119Espacenet
JP 2023554181 A2023-12-2614P32119Espacenet
JP 2023123507 A2023-09-05238P32119Espacenet
KR 1020230118888 A2023-08-1412P32119Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,680

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRDX2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA012197Cancer Center Support Grant92025
R01HL146442The role of ferroptosis in red cell aging in vivo and in vitro92025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology72025
R01AG044034Oxidative Stress and the Development of Osteoarthritis42025
R01HL161004The paradoxical response to iron in pulmonary hypertension of sickle cell disease42025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA013696Cancer Center Support Grant32025

1 to 10 of 1,680Source NIH's project files

See all 1,680 nih grants

Papers3,161

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prdx2 suppresses the erythroid differentiation by modulating the ROS-JNK1 signaling axis.Biochim Biophys Acta Mol Basis Dis202742607897PubTator, text miningPubMed
Peroxiredoxin II as a metabolic gatekeeper against aflatoxin B1-induced hepatic steatosis: restoration of PPARα/γ balance via mitochondrial ROS scavenging.Mycotoxin Res202642809160PubTator, text miningPubMed
Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study.Biomed Pharmacother202642700616PubTator, text miningPubMed
Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis.JHEP Rep202642628796PubTator, text miningPubMed
Placental PRDX2-VEGFA/ENG network rewiring links oxidative stress to angiogenic failure in preeclampsia: A multi-cohort transcriptomic study.Comput Biol Chem202642603350PubTator, text miningPubMed
Correction: Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue.Sci Rep202642586996PubTator, text miningPubMed
Role of Reactive Oxygen Species in Chronic Rhinosinusitis: A Narrative Review.Curr Issues Mol Biol202642510949PubTator, text miningPubMed
Gene- and Isoform-Level Responses to Extreme Acidic pH Stress in an Emerging Marine Invertebrate Model Organism Litoditis marina.Antioxidants (Basel)202642510593PubTator, text miningPubMed
Comparative Evaluation of Serum Peroxiredoxin 2 (PRDX2), Serum Peroxiredoxin 4 (PRDX4), and Plasma Methylated Septin 9 (mSEPT9) Levels Against Conventional Biomarkers for Early Detection of Colorectal Cancer: A Study Protocol.
Cureus202642404326PubTator, text miningPubMed
Proteomics analysis of empagliflozin in patients without diabetes or overt heart failure from empagliflozin and cardiac remodeling in people without diabetes CardioLink-7 randomized clinical trial.Cardiovasc Endocrinol Metab202642367684PubTator, text miningPubMed

1 to 10 of 3,161

See all 3,161 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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