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Gene · 7004

TEAD4: TEA domain transcription factor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TEAD4: TEA domain transcription factor 4. Genes, record 7004. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7004

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Gene

Symbol
TEAD4
HGNC
Name
TEA domain transcription factor 4
HGNC
NCBI Gene ID
7004
NCBI Gene
HGNC ID
HGNC:11717
HGNC
Ensembl
ENSG00000197905
NCBI Gene
Aliases
EFTR-2, RTEF-1, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15561Transcriptional enhancer factor TEF-343423Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026017877 A12026-01-2242Q15561Espacenet
JP 2025147176 A2025-10-0615744Q15561Espacenet
JP 2025028160 A2025-02-2815744Q15561Espacenet
KR 1020250010750 A2025-01-2115744Q15561Espacenet
JP 2024109657 A2024-08-1415583Q15561Espacenet
US 11925651 B22024-03-124Q15561Espacenet
JP 2023553866 A2023-12-264Q15561Espacenet
US 11760728 B22023-09-194Q15561Espacenet
KR 1020230131189 A2023-09-124Q15561Espacenet
JP 2022147356 A2022-10-06293Q15561Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,396

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTEAD4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant132025
R01HD062546GATA Factor Function in Trophoblast72025
R01EY015708Control of Cell Number in Developing Retina62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
P30CA016087Cancer Center Support Grant42025
P30CA086862Cancer Center Support Grant42025
P30DK034854Integrated Epithelial and Muscosal Biology42025

1 to 10 of 1,396Source NIH's project files

See all 1,396 nih grants

Papers1,824

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptional Heterogeneity Underlying Cancer Cell Migration Converges on Shared Regulatory Programs.Genes (Basel)202642792937PubTator, text miningPubMed
Dysregulation of SCARB1 Alternative Splicing Disturbs Amino Acid Metabolism in Anembryonic Pregnancy.Reprod Sci202642778874PubTator, text miningPubMed
A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma.Transl Oncol202642696959PubTator, text miningPubMed
YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.Acta Pharmacol Sin202642680799PubTator, text miningPubMed
Bisphenol A promotes colorectal cancer malignancy through CXCL8 upregulation associated with p38 MAPK activation: A potential link to type 2 diabetes mellitus comorbidity.Chem Biol Interact202642660439PubTator, text miningPubMed
Marine-Derived Fungal Metabolite MHO7 Promotes Breast Cancer Apoptosis as a Hippo Pathway Regulator by Modulating the YAP-TEAD Axis.Mar Drugs202642646473PubTator, text miningPubMed
Single-cell analysis identifies a VIM+ glioma stem-like vascular-immune state linked to myeloid OSM signaling and CEBPD activity.Front Immunol202642643588PubTator, text miningPubMed
Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids.bioRxiv202642620194PubTator, text miningPubMed
KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer.Cancer Res202642525957PubTator, text miningPubMed
EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple-Negative Breast Cancer Progression.Adv Sci (Weinh)202642496060PubTator, text miningPubMed

1 to 10 of 1,824

See all 1,824 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7004

GET https://conductscience.org/api/genes/v1/7004/patents?page=2