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Gene · 701

BUB1B: BUB1 mitotic checkpoint serine/threonine kinase B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BUB1B: BUB1 mitotic checkpoint serine/threonine kinase B. Genes, record 701. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/701

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Gene

Symbol
BUB1B
HGNC
Name
BUB1 mitotic checkpoint serine/threonine kinase B
HGNC
NCBI Gene ID
701
NCBI Gene
HGNC ID
HGNC:1149
HGNC
Ensembl
ENSG00000156970
NCBI Gene
Aliases
BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60566Mitotic checkpoint serine/threonine-protein kinase BUB1 beta1,0509Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-294691O60566Espacenet
JP 2025062604 A2025-04-1410043O60566Espacenet
JP 2025032204 A2025-03-1125278O60566Espacenet
KR 1020250017231 A2025-02-044691O60566Espacenet
EP 4461818 A22024-11-1325278O60566Espacenet
JP 2024123008 A2024-09-105198O60566Espacenet
JP 2023058610 A2023-04-2525278O60566Espacenet
US 11446398 B22022-09-2010043O60566Espacenet
JP 2022524081 A2022-04-27113014O60566Espacenet
JP 2020508652 A2020-03-2625278O60566Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,853

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBUB1B papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase242025
P30CA008748Cancer Center Support Grant182025
P30CA021765Cancer Center Support Grant (CCSG)142025
P30CA016672Cancer Center Support Grant102025
R01GM074215Kinetochore Specification and Function92025
P30CA014520UW Comprehensive Cancer Center Support82025
P30CA016086Cancer Center Support Grant82025
P30CA046934University of Colorado Cancer Center Support Grant82025
P30CA015704Cancer Center Support Grant72025
P30CA023108Cancer Center Support Grant72025

1 to 10 of 1,853Source NIH's project files

See all 1,853 nih grants

Papers3,969

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immune cell enrichment characteristics and related key genes in intrauterine adhesion: insights from RNA-sequencing analysis.Syst Biol Reprod Med202642763899PubTator, text miningPubMed
BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer.Cancer Res202642757823PubTator, text miningPubMed
Identification of functional genes and immune cell infiltration analysis in liposarcoma.PLoS One202642726806PubTator, text miningPubMed
MYBL2 promotes malignant phenotypes and M2-like macrophage polarization through CCL2 in non-small cell lung cancer.Mol Cell Biochem202642720907PubTator, text miningPubMed
An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development.FASEB J202642667124PubTator, text miningPubMed
Comprehensive Proteomic Profiling of Alternaria gansuense Provides Insights into Candidate Virulence-Associated Proteins and Core Physiological Features.Curr Issues Mol Biol202642651816PubTator, text miningPubMed
Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.Cancer Res Commun202642647139PubTator, text miningPubMed
Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer.bioRxiv202642619900PubTator, text miningPubMed
Exploratory Preoperative Risk Stratification of Uterine Mesenchymal Tumors in Postmenopausal Women with Complementary Transcriptomic Analysis.Diagnostics (Basel)202642587646PubTator, text miningPubMed
An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.Gene202642551718PubTator, text miningPubMed

1 to 10 of 3,969

See all 3,969 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/701

GET https://conductscience.org/api/genes/v1/701/patents