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TERT: telomerase reverse transcriptase

1 protein, 423 patents, 2 drugs, 26 trials, 9,358 NIH grants and 25,535 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTERTHGNC
Nametelomerase reverse transcriptaseHGNC
NCBI Gene ID7015NCBI Gene
HGNC IDHGNC:11730HGNC
EnsemblENSG00000164362NCBI Gene
AliasesCMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14746Telomerase reverse transcriptase1,13232Ensembl, GeneID, HGNCUniProt

Patents 423

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026163710 A2026-08-061O14746Espacenet
WO 2026163711 A2026-08-061O14746Espacenet
JP 2026525611 A2026-07-31376O14746Espacenet
JP 2026525612 A2026-07-31474O14746Espacenet
JP 2026098132 A2026-06-161555O14746Espacenet
US 12565666 B22026-03-031601O14746Espacenet
JP 2026027383 A2026-02-1837O14746Espacenet
US 12539325 B22026-02-0381O14746Espacenet
JP 2026004568 A2026-01-1466709O14746Espacenet
JP 2025172847 A2025-11-261601O14746Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IMETELSTATCHEMBL2107856Telomerase reverse transcriptase inhibitorINHIBITORChEMBL
IMETELSTAT SODIUMCHEMBL2108702Telomerase reverse transcriptase inhibitorINHIBITORChEMBL

Trials 26

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07549451IMETELSTATPHASE2ClinicalTrials.gov
NCT07320235IMETELSTATPHASE1ClinicalTrials.gov
NCT06247787IMETELSTATPHASE1ClinicalTrials.gov
NCT05937568IMETELSTATClinicalTrials.gov
NCT05583552IMETELSTATPHASE2ClinicalTrials.gov
NCT05371964IMETELSTAT SODIUMPHASE1ClinicalTrials.gov
NCT04576156IMETELSTATPHASE3ClinicalTrials.gov
NCT02598661IMETELSTAT SODIUMPHASE2/PHASE32025-02-14ClinicalTrials.gov
NCT02426086IMETELSTATPHASE22021-09-14ClinicalTrials.gov
NCT01916187IMETELSTATPHASE1ClinicalTrials.gov

NIH grants 9358

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant3732,025NIH's project files
P30CA016672Cancer Center Support Grant2232,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant672,025NIH's project files
P50CA097257Brain Tumor SPORE Grant632,025NIH's project files
P30CA006973Regional Oncology Research Center532,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)482,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award442,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant422,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)362,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program352,025NIH's project files

Papers 25535

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826912PubTator, text miningPubMed
42823681PubTator, text miningPubMed
42811420PubTator, text miningPubMed
42810491PubTator, text miningPubMed
42809874PubTator, text miningPubMed
42809730PubTator, text miningPubMed
42809287PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42807929PubTator, text miningPubMed
42807166PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license