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Gene · 7023

TFAP4: transcription factor AP-4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TFAP4: transcription factor AP-4. Genes, record 7023. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7023

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Gene

Symbol
TFAP4
HGNC
Name
transcription factor AP-4
HGNC
NCBI Gene ID
7023
NCBI Gene
HGNC ID
HGNC:11745
HGNC
Ensembl
ENSG00000090447
NCBI Gene
Aliases
AP-4, bHLHc41
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01664Transcription factor AP-43380Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19222Q01664Espacenet
JP 2025147176 A2025-10-0615757Q01664Espacenet
JP 2025517970 A2025-06-12222Q01664Espacenet
JP 2025506185 A2025-03-0730Q01664Espacenet
JP 2025028160 A2025-02-2815757Q01664Espacenet
KR 1020250010750 A2025-01-2115757Q01664Espacenet
EP 4479067 A22024-12-2530Q01664Espacenet
JP 2024109657 A2024-08-1415596Q01664Espacenet
JP 2023544161 A2023-10-2059Q01664Espacenet
US 11446398 B22022-09-2089852Q01664Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,181

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFAP4 papersNewest fiscal year
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System252025
K08NS123552Development of a Translational Research Platform to Understand and treat Defective Protein Trafficking in Childhood-Onset Hereditary Spastic Paraplegia82025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center52025
R35GM119525Molecular mechanisms of coat assembly and regulation in membrane trafficking pathways52025
P30AI050410The University of North Carolina Center for AIDS Research42025
P30CA016672Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
P30EY008126Core Grant in Vision Research32025

1 to 10 of 1,181Source NIH's project files

See all 1,181 nih grants

Papers1,530

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors.J Clin Invest202642678737PubTator, text miningPubMed
Splice effect of a synonymous variant in AP4B1: multiomics approach establishes the diagnosis in two sisters with spastic paraplegia.Hum Mutat202642597316PubTator, text miningPubMed
Clinical and genetic characteristics of pediatric hereditary spastic paraplegia in the Eastern Levant.Eur J Paediatr Neurol202642462372PubTator, text miningPubMed
Potential Relationship Between YTHDF3 and CFTR in Myocardial Ischemia-Reperfusion Injury.J Cell Mol Med202642265766PubTator, text miningPubMed
GOT1 promotes endometrial cancer progression by regulating ferroptosis through the STAT3-GPX4 axis and attenuating medroxyprogesterone acetate sensitivity.Cancer Gene Ther202642230821PubTator, text miningPubMed
Carbonized Composites Containing Silica Aerogels with Enhanced Hydrophobicity and Thermal Insulation via Glass Fiber and Hollow Microsphere Reinforcement.Gels202642196123PubTator, text miningPubMed
Identification of Key Genes and Exploration of Therapeutic Targets for Chronic Tendon Injury Based on Bioinformatics and Machine Learning.Int J Gen Med202642157878PubTator, text miningPubMed
CRISPR/Cas9 loss-of-function screen in a neuronal model of AP-4 deficiency identifies ATG9A trafficking modulators.JCI Insight202642154535PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
YqeK governs the acquisition and removal of nucleoside tetraphosphate caps in Firmicutes.Nucleic Acids Res202641873760PubTator, text miningPubMed

1 to 10 of 1,530

See all 1,530 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7023

GET https://conductscience.org/api/genes/v1/7023/patents?page=2