Gene · 7031
TFF1: trefoil factor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TFF1: trefoil factor 1. Genes, record 7031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7031
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P04155 | Trefoil factor 1 | 84 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents106
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12656346 B2 | 2026-06-16 | 4 | P04155 | Espacenet |
| WO 2026022373 A1 | 2026-01-29 | 20 | P04155 | Espacenet |
| EP 4684804 A1 | 2026-01-28 | 20 | P04155 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67924 | P04155 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3465 | P04155 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13131 | P04155 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7864 | P04155 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7864 | P04155 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3465 | P04155 | Espacenet |
| JP 2025514630 A | 2025-05-09 | 20 | P04155 | Espacenet |
1 to 10 of 106
See all 106 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,959
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TFF1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 18 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 16 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 16 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 14 | 2025 |
| R01DK018477 | Enhancer Connectomes in Regulation of Gene Expression | 11 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 10 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 7 | 2025 |
| R01HD008188 | Reproductive Hormones - Biological and Molecular Actions | 7 | 2025 |
1 to 10 of 1,959Source NIH's project files
See all 1,959 nih grantsPapers3,695
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Alcohol Promotes ER+ Breast Cancer Cell Proliferation and Invasion Through the Upregulation of Neuregulin 1-Mediated ER-ErbB3 Crosstalk. | bioRxiv | 2026 | 42818202 | PubTator, text mining | PubMed |
| Trefoil Factor 1 contributes to Paclitaxel and Lapatinib resistance in brain metastatic breast cancer cells. | Biochem Cell Biol | 2026 | 42804787 | PubTator, text mining | PubMed |
| Sakuranetin modulates estrogen receptor signaling in breast cancer cells. | J Funct Foods | 2026 | 42719784 | PubTator, text mining | PubMed |
| Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma. | J Pathol | 2026 | 42711771 | PubTator, text mining | PubMed |
| Protocol for measuring endocrine-disruptive effects on transcriptional bursting using single-molecule imaging in human breast cancer cells. | STAR Protoc | 2026 | 42709549 | PubTator, text mining | PubMed |
| Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation. | Front Genet | 2026 | 42695096 | PubTator, text mining | PubMed |
| Shengjiang powder ameliorates gastric mucosal injury through activating SIRT1/FOXO1 anti-oxidative stress. | Front Pharmacol | 2026 | 42666336 | PubTator, text mining | PubMed |
| Patient-Derived Organoid and Single-Cell Multiomics Reveal Evolution Driven by CEACAM6/KRT19-Mediated Heterogeneity. | FASEB J | 2026 | 42622615 | PubTator, text mining | PubMed |
| AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination. | Cell Death Differ | 2026 | 42436338 | PubTator, text mining | PubMed |
| Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain. | Elife | 2026 | 42412908 | PubTator, text mining | PubMed |
1 to 10 of 3,695
See all 3,695 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7031
GET https://conductscience.org/api/genes/v1/7031/patents?page=2