ConductScience.org, home

Gene · 7031

TFF1: trefoil factor 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TFF1: trefoil factor 1. Genes, record 7031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7031

On this page

Gene

Symbol
TFF1
HGNC
Name
trefoil factor 1
HGNC
NCBI Gene ID
7031
NCBI Gene
HGNC ID
HGNC:11755
HGNC
Ensembl
ENSG00000160182
NCBI Gene
Aliases
BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04155Trefoil factor 1843Ensembl, GeneID, HGNC

Source UniProt

Patents106

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12656346 B22026-06-164P04155Espacenet
WO 2026022373 A12026-01-2920P04155Espacenet
EP 4684804 A12026-01-2820P04155Espacenet
JP 2026004568 A2026-01-1467924P04155Espacenet
EP 4650780 A22025-11-193465P04155Espacenet
JP 2025147176 A2025-10-0613131P04155Espacenet
JP 2025529142 A2025-09-047864P04155Espacenet
US 12371689 B22025-07-297864P04155Espacenet
JP 2025517970 A2025-06-123465P04155Espacenet
JP 2025514630 A2025-05-0920P04155Espacenet

1 to 10 of 106

See all 106 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,959

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFF1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant192025
P30DK058404Molecular and Cellular Basis for Digestive Diseases182025
P30CA068485Cancer Center Support Grant162025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant142025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant142025
R01DK018477Enhancer Connectomes in Regulation of Gene Expression112025
P30DK056338Texas Medical Center Digestive Diseases Center102025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer72025
R01HD008188Reproductive Hormones - Biological and Molecular Actions72025

1 to 10 of 1,959Source NIH's project files

See all 1,959 nih grants

Papers3,695

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Alcohol Promotes ER+ Breast Cancer Cell Proliferation and Invasion Through the Upregulation of Neuregulin 1-Mediated ER-ErbB3 Crosstalk.bioRxiv202642818202PubTator, text miningPubMed
Trefoil Factor 1 contributes to Paclitaxel and Lapatinib resistance in brain metastatic breast cancer cells.Biochem Cell Biol202642804787PubTator, text miningPubMed
Sakuranetin modulates estrogen receptor signaling in breast cancer cells.J Funct Foods202642719784PubTator, text miningPubMed
Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma.J Pathol202642711771PubTator, text miningPubMed
Protocol for measuring endocrine-disruptive effects on transcriptional bursting using single-molecule imaging in human breast cancer cells.STAR Protoc202642709549PubTator, text miningPubMed
Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation.Front Genet202642695096PubTator, text miningPubMed
Shengjiang powder ameliorates gastric mucosal injury through activating SIRT1/FOXO1 anti-oxidative stress.Front Pharmacol202642666336PubTator, text miningPubMed
Patient-Derived Organoid and Single-Cell Multiomics Reveal Evolution Driven by CEACAM6/KRT19-Mediated Heterogeneity.FASEB J202642622615PubTator, text miningPubMed
AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination.Cell Death Differ202642436338PubTator, text miningPubMed
Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain.Elife202642412908PubTator, text miningPubMed

1 to 10 of 3,695

See all 3,695 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7031

GET https://conductscience.org/api/genes/v1/7031/patents?page=2