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Gene · 7032

TFF2: trefoil factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TFF2: trefoil factor 2. Genes, record 7032. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7032

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Gene

Symbol
TFF2
HGNC
Name
trefoil factor 2
HGNC
NCBI Gene ID
7032
NCBI Gene
HGNC ID
HGNC:11756
HGNC
Ensembl
ENSG00000160181
NCBI Gene
Aliases
SML1, SP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03403Trefoil factor 21290Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026022373 A12026-01-2921Q03403Espacenet
EP 4684804 A12026-01-2821Q03403Espacenet
JP 2026004568 A2026-01-1467925Q03403Espacenet
EP 4650780 A22025-11-193464Q03403Espacenet
JP 2025158975 A2025-10-171Q03403Espacenet
JP 2025147176 A2025-10-0613132Q03403Espacenet
JP 2025529142 A2025-09-047865Q03403Espacenet
US 12371689 B22025-07-297865Q03403Espacenet
JP 2025517970 A2025-06-123464Q03403Espacenet
JP 2025514630 A2025-05-0921Q03403Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants861

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFF2 papersNewest fiscal year
P30DK058404Molecular and Cellular Basis for Digestive Diseases382025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital302025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.272025
R01DK094989REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS242025
R01DK101332Induction and Evolution of Metaplasia in the Stomach242025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease232025
R01DK105129MECHANISMS OF CHIEF CELL DEDIFFERENTIATION232025
P30CA068485Cancer Center Support Grant192025
P30CA091842Cancer Center Support Grant112025
P30DK056338Texas Medical Center Digestive Diseases Center112025

1 to 10 of 861Source NIH's project files

See all 861 nih grants

Papers1,620

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Autoimmune gastritis diverges from a shared corpus origin: molecular reconstruction of the adenocarcinoma axis and clinical anchoring of the neuroendocrine axis.Front Immunol202642712509PubTator, text miningPubMed
Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma.J Pathol202642711771PubTator, text miningPubMed
Shengjiang powder ameliorates gastric mucosal injury through activating SIRT1/FOXO1 anti-oxidative stress.Front Pharmacol202642666336PubTator, text miningPubMed
Glycolytic reprogramming in precancerous lesions of gastric cancer progression: pathogenesis and therapeutic potential.Front Oncol202642657117PubTator, text miningPubMed
Retraction Statement.Digestion202642536604PubTator, text miningPubMed
Crosstalk between TFF2+ HCC cells and regulatory T cells drives hepatocellular carcinoma prometastatic niche formation and portal vein tumor thrombosis.Cell Signal202642471073PubTator, text miningPubMed
Physical, chemical, and structural properties of human gastric organoid-derived mucus.Am J Physiol Gastrointest Liver Physiol202642460667PubTator, text miningPubMed
SRY-Box 9-Driven Spasmolytic Polypeptide-Expressing Metaplasia Cell Lineage Plasticity Is a Potential Therapeutic Target That Mitigates Risk of Metaplastic Progression to Gastric Cancer.Gastroenterology202642448241PubTator, text miningPubMed
Spasmolytic Polypeptide-Expressing Metaplasia in Chronic Atrophic Gastritis and Its Role in the Progression From Gastritis to Gastric Cancer.J Dig Dis202642438264PubTator, text miningPubMed
Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review).Mol Med Rep202642429138PubTator, text miningPubMed

1 to 10 of 1,620

See all 1,620 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7032

GET https://conductscience.org/api/genes/v1/7032/patents?page=2