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Gene · 7033

TFF3: trefoil factor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TFF3: trefoil factor 3. Genes, record 7033. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7033

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Gene

Symbol
TFF3
HGNC
Name
trefoil factor 3
HGNC
NCBI Gene ID
7033
NCBI Gene
HGNC ID
HGNC:11757
HGNC
Ensembl
ENSG00000160180
NCBI Gene
Aliases
HITF, ITF, P1B, TFI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07654Trefoil factor 3803Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025166063 A12025-08-0712Q07654Espacenet
WO 2020043864 A12020-03-052585Q07654Espacenet
US 9347952 B22016-05-24440Q07654Espacenet
WO 2015174544 A2015-11-1945Q07654Espacenet
JP 2013537168 A2013-09-303Q07654Espacenet
EP 2567970 A12013-03-13440Q07654Espacenet
WO 2011150944 A12011-12-083Q07654Espacenet
US 7951546 B22011-05-3159Q07654Espacenet
US 7939268 B22011-05-1059Q07654Espacenet
WO 2011044902 A12011-04-213Q07654Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,598

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFF3 papersNewest fiscal year
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital332025
P30DK058404Molecular and Cellular Basis for Digestive Diseases162025
P30CA008748Cancer Center Support Grant122025
P30CA068485Cancer Center Support Grant112025
R01DK101332Induction and Evolution of Metaplasia in the Stomach112025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.102025
R01AG034853Biomarker-Based Diagnostic Algorithms To Prevent, Detect And Guide Treatment Of Kidney Disease In Persons Living With HIV82025
P30CA016672Cancer Center Support Grant72025
P30DK034987Center for Gastrointestinal Biology and Disease62025
P30DK056338Texas Medical Center Digestive Diseases Center62025

1 to 10 of 1,598Source NIH's project files

See all 1,598 nih grants

Papers3,041

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diagnostic Value of Serum HE4, TFF3, and CA72-4 for Gastric Cancer Stratified by Helicobacter pylori Infection Status.Br J Hosp Med (Lond)202642812095PubTator, text miningPubMed
Serum Trefoil Factor 3 in Endometrioid Endometrial Carcinoma: Exploratory Diagnostic Value and Association with Lymphovascular Space Invasion.J Clin Med202642739604PubTator, text miningPubMed
Adhesion-Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin-Responsive IBD Therapy.Adv Sci (Weinh)202642725754PubTator, text miningPubMed
Longitudinal assessment of glomerular and tubular kidney function after COVID-19: a prospective cohort study.Scand J Clin Lab Invest202642690026PubTator, text miningPubMed
Decoding chromosomal instability in neutrophil signature in the pathogenesis of periodontitis: evidence from artificial intelligence-driven multi-omics and in vitro validation.Cytotechnology202642670405PubTator, text miningPubMed
Diagnostic Accuracy of a Capsule Sponge Trefoil Factor 3 Test for Barrett's Esophagus in Patients With Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis.Am J Gastroenterol202642669464PubTator, text miningPubMed
Correction: Hepatic origin of increased serum TFF3 in gastric cancer bearing subjects.Gastric Cancer202642640351PubTator, text miningPubMed
Patient-Derived Organoid and Single-Cell Multiomics Reveal Evolution Driven by CEACAM6/KRT19-Mediated Heterogeneity.FASEB J202642622615PubTator, text miningPubMed
Impact of a durable left ventricular assist device on inflammation and cardiac remodelling in subjects with advanced heart failure.Open Heart202642580841PubTator, text miningPubMed
Oxygen-enhanced assembloid-based vascularized intestinal-on-a-chip for radioprotective drug evaluation.Front Toxicol202642534747PubTator, text miningPubMed

1 to 10 of 3,041

See all 3,041 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7033

GET https://conductscience.org/api/genes/v1/7033/patents?page=2